Physiologic Changes During Pregnancy Flashcards

1
Q

Why does upper airway swelling occur during pregnancy?

A

Increased progesterone, estrogen and relaxin cause vascular engorgement and hyperemia.

Increased extracellular fluid volume

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2
Q

Change in Mallampati score during pregnancy

A

Increases

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3
Q

Risk of difficult/ failed intubation during pregnancy

A

Increases (up to 8x in full term pts)

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4
Q

Change in glottic opening during pregnancy

A

Narrowed

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5
Q

Change in airway equipment for pregnant patients

A

Short handled laryngoscope (Datta handle)

Downsized ETT (6.0 - 7.0)

Avoid nasal airways

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6
Q

How does lung/ diaphragmatic physiology change during pregnancy?

A

Ribs more horizontal d/t relaxin relaxing the ligaments of the ribcage

AP diameter of chest increases> lungs have more space

As uterus grows, diaphragm moves cephalad

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7
Q

How do lung volumes and capacities change during pregnancy?

A

Decrease in expiratory reserve volume and residual volume = decrease in functional residual capacity

FRC falls below closing capacity= airway closure during tidal breathing

No change in vital capacity and closing capacity

Total lung capacity decreases by 5%

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8
Q

How does progesterone affect breathing?

A

Respiratory stimulant

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9
Q

How does OxyHgb dissociation curve change in pregnancy?

A

Rightward shift (d/t increased P50)

Facilitates transfer to fetus

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10
Q

How do ABGs change during pregnancy?

A

Increased PaO2 (104-108 mmHg) d/t hyperventilation

Decreased PaCO2 (28-32 mmHg)

Decreased HCO3 (20 mmol/L)

No change in pH

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11
Q

How does minute ventilation change during pregnancy?

A

Increased (by 50%)

Vt increases by 40%
RR increases by 10%

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12
Q

How does oxygen consumption change in pregnancy?

A

Increases by 20% at term

Increases by 40% over prelabor value in the first stage of labor

Increases by 75% over prelabor value in the second stage of labor

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13
Q

When does cardiac output return to pre-labor values?

A

24-48 hours

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14
Q

When does cardiac output return to pre-pregnancy values?

A

~ 2 weeks

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15
Q

What percentage of cardiac output does the uterus recieve?

A

10%

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16
Q

By what percentage does cardiac output increase during pregnancy?

A

40%

17
Q

How does SVR change during pregnancy?

A

Decreased d/t progesterone

18
Q

Why does the MAP not change during pregnancy?

A

There is an increased blood volume but decreased SVR/ DBP = no net effect on MAP

19
Q

By what mechanism does progesterone decrease SVR and PVR?

A

Increasing nitric oxide > vasodilation

Decreasing response to angiotensin and norepinephrine

20
Q

How does pregnancy affect filling pressures?

A

There is no change in filling pressures in pregnancy until uterine contraction occurs > autotransfusion occurs > filling pressures increase

21
Q

How does cardiac axis deviation change during pregnancy?

A

Diaphragm pushes cephalad > heart is pushed up and to the left > L axis deviation

22
Q

What is the pathophysiology of aortocaval compression syndrome?

A

The gravid uterus compresses the vena cava and the aorta > decreased blood flow to the heart/ extremities/ uterus > fetal perfusion compromised/ mother loses consciousness

23
Q

How is aortocaval compression prevented in pregnancy?

A

Elevate the mother’s right torso 15 degrees starting in the second trimester

24
Q

How does intravascular volume change during pregnancy?

A

Increases by about 35%:

Plasma 45%
Erythrocyte 20%

25
Q

What clotting factors increase during pregnancy?

A

1, 7, 8, 9, 10, 12

26
Q

How does fibrin break down change during pregnancy?

A

Increases to compensate for the hypercoagulable state

Mother makes more clots, but breaks them down faster

27
Q

How do PT/ PTT change during pregnancy?

A

They both decrease by up to 20%

Normal PT at term: 9.6-12.9 s
Normal PTT at term: 24.7- 35 s

28
Q

What are causes of thrombocytopenia in pregnancy?

A

Gestational thrombocytopenia (hemodilutional and consumption) - most common

Hypertensive disorders

Idiopathic

29
Q

How does MAC change during pregnancy?

A

Decreases by 30-40% beginning at 8-12 weeks d/t progesterone

30
Q

How does response to local anesthetics change during pregnancy?

A

Increased sensitivity d/t progesterone

31
Q

How do subarachnoid and epidural space volumes change during pregnancy?

A

Decrease d/t increase in volume of epidural vein and compression

32
Q

How does gastrin change during pregnancy

A

Increase

33
Q

How does the change in gastrin affect the pregnant patient?

A

Increase in gastric volume
Decrease in gastric pH

34
Q

Why does lower esophageal sphincter tone decrease during pregnancy?

A

Increased progesterone

Increased estrogen

Cephalad displacement of the diaphragm

35
Q

How does renal function change during pregnancy?

A

Increased cardiac output/ blood volume > GFR/ creatinine clearance/ glucose in urine all increase > creatinine and BUN/ renal absorption decrease

36
Q

What is uterine blood flow in mL/min?

A

Up to 700-900 mL/min

37
Q

How do changes in serum albumin affect anesthesia for pregnant patients?

A

Albumin decreases > increase in free fraction of highly protein- bound drugs

38
Q

How does the change in pseudocholinesterase affect anesthesia for pregnant patients?

A

Pseudocholinesterase decreases in pregnancy, but there is not meaningful change in anesthesia approaches d/t this change