Physio Flashcards by Cha Monsale

Normal Nerve RMP (TN handout)

-70mV

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N activation gate
Na inward current
“ON”
(TN handout)

Depolarization

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Closure of Na inactivation gatr
Stop Na inward
K outward current
“OFF”

Repolarization(TN handout)

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Tissue macrophage (Nervous system)

Microglia (TN handout)

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Forms Myelin

CNS: Oligodendrocytes
PNS: Schwann Cells
(TN handout)

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Envelop synapses

Form BBB

ASTROCYTes
Fibrous astrocyte - white matter
Protoplasmic aatrocytes - gray matter
(TN handout)

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ACtion potential starts?

Axon hillock/initial segment

TN handout

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Autoimmune disease
Paraperesis, optic neuritis, paresthesia
Exacerbated by inc temp

Multiple sclerosis
Relapsing-remitting or primary progressive
(TN handout)

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Increase in Na Conductance

NA INFLUX

Endplate Potential (Skeletal.Ms endplate)
(TN handout)

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Cl influx
K efflux
Closure of Na or Ca Channels

FAST Inhibitory Post Synaptic Potential (IPSP)

TN handout

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Na Influx

Ca influx

FAST Excitatory postsynaptic Potential

TN handout

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Slow K efflux

SLOW ExCitatory Postsynaptic Potential

TN handout

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K efflux

Presynaptic Inhibition
(TN handout)

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Brain Main INHIBITORY NT

GABA

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BRAIN MAIN EXCITATORY NT

Glutamate

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Spinal Cord MAIN INHIBITORY NT

Glycine

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Utilize 2nd messengers like IP3/DAG or cAMP

GABA B, neurokinin receptor, opioid receptor

G Protein Coupled Receptors

Ion channel linked receptors

GABA A, Nicotinic, NMDA, Glycine, ANP, 5HT3 receptors

INOTROPIC RECEPTORS

Opioid Peptide receptors:

Analgesia, diuresis, sedation, meiosis, dysphoria
Enk> End & Dyno

KAPPA

Opioid Peptide receptors:

action of morphine
Endorphins > Enk > Dyno

MU receptor

= 61.5log[Ko+] / [Ki+] @ 37°C

Equilibrium Potential for K+
K+= -90mV
Cl= -70mV
Na = +60mV

Amino acid sequence of CHON

PRimary structure
(TN handout)

Twists, folds, or twists and folds of AA seq into stabilized struc

SECONDARY structure

Arrangement of twisted chains and folds w/n a protein into stable struxture.

Tertiary Structure

Arrangement of subunits to form functional struc

Quarternary Structure

Major Lipoprotein src of Cholesterol used in cells

LDL

Bring about short term changes in cell fx by altering enzyme fx, trigger exocytosis, alteration of transcription.

Second messengers

Organelles for postranslational process of proteins

GOLGI complex

Plasma membrane proteins that couplr extracellular bindinh of primary signaling molecules yo activation of heterotrimeric G protein

G PROTEIN COUPLEE RECEPTORS

Provides structural component for cell movement

FILAMRNTOUS ACTIN

Nerve fiber with slowest conduction velocity

A alpha > A Beta > A delta > B > C

Made of 3 polypeptide subunits Express both p75NTR and TRK A receptors Neccessary fo4 growth and devt of sympa and cholinergic neurons in basal forebrain and striatum

NERVE GROWTH FACTOR

Distance --------- Latent Period

Conduction Velocity

_____ is Essential for contraction, spread inwards to all parts of ms via the ____; Triggers release of ___

- Action potential of skeletal ms - T tubules - Calcium

Sliding in actin to produce shortening/crossbridging

Myosin

Relaxing protein at rest by covering where myosin binds to actin

Tropomyosin

More tension when ms contracts ____ | More work when ms contracts ____

Isometrically | Isotonically

Monoamines, catecholamines, amino acids

Small molecule transmitters

Substance P Enkephalins Vasopressin

Large molecule transmitters

Gaba b VIP NE Metamorphic glutamate receptor

Metabotropic/GPCR