Physics Review Flashcards
Describe Solids
Closely approximated atoms due to lattice and greatly influenced by intermolecular forces. Non-compressible and have volume, shape, and limited motion. If you add heat, the lattice structure breaks down, and molecules move further apart. Ex- Ice melting.
Describe Liquids
Molecules exert weaker forces on each other, known as Van der Waals forces. Allows molecules to flow and move throughout the substance. A decrease in the force between molecules enable them to take the shape of a container while still having volume. Have more kinetic energy than solids.
What are Van der Waals forces?
A weak force exists between molecules in a liquid state. Allows for molecules to flow.
Describe Gases
Molecules are independent of each other and constantly moving, hitting the side of their container. No definite shape or volume. Pressure can be generated by the compression of gas in a chamber and is measured by flowmeters or respirometers. This pressure is the force exerted by the gas on the chamber walls.
What is the pressure exerted by vapor when, ay any one temperature, an equilibrium is reached at which the same number of molecules are vaporizing as are returning to liquid?
Saturated Vapor Pressure
What is the temperature at which vapor pressure becomes equal to atmospheric pressure and at which all liquid changes to gas?
Boiling point
Describe the relationship between vapor pressure and boiling points.
They are inversely related. The lower the boiling point, the higher the vapor pressure. This is why there are specific vaporizers needed for specific anesthetic gases.
This means vapor pressure is temperature dependent.
Is vapor pressure a function of volume, temperature, or pressure?
Temperature
What are the vapor pressures for gases at 20 degrees C?
Sevoflurane, 170 mmHg
Isoflurane, 240 mmHg
Halothane, 244 mmHg
Desflurane, 669 mmHg
Describe Force
Force is what changes or tends to change the state of rest or motion of an object. This is measured in N (newton).
N- gives a mass of 1 kg an acceleration of 1 m/s^2
Equation: F=ma
This is mass multiplied by acceleration (Newton’s second law)
Ex- gravity, force of air through valves in ventilator, force of fluid through IV, force of ETT on surrounding tissue.
Describe Pressure
Pressure is the force applied over a surface area. It is measured in pascal (Pa). This is the pressure of 1 newton acting over 1 square meter - N/m^2
What do we typically use to measure pressure?
The kPa or the kilopascal. This is used because the pascal is too small of a number to be manageable.
psi is pounds per square inch and is also used to measure pressure. (British)
Atmospheric Pressure = 1 bar
Provide the remaining conversions
= 100 kPa
=760 mmHg
=1034 cmH2O
=14.7 psi
1 kPa = 7.5 mmHg
= 10.34 cmH2O
=0.147 psi
What is absolute pressure?
This equals gauge pressure plus atmospheric pressure. (gauge pressure is the important parameter in most cases)
Ex- gas-cylinder pressures (psig or pounds per square inch gauge). When a cylinder is empty, it will say 0 psi or 0 bar. This does not mean that it is truly empty, but the O2 is equal to atmospheric pressure (14.7 psi or 1 bar), and no more gas can be removed.
What is important to remember with gas laws?
Temp must be measure in Kelvin for gas laws. Remember Kelvin = Celcius + 273. There is no degree sign.
Absolute zero 0 K or -273 degrees C
1 unit K is 1 degree C
What is Boyle’s Law?
At a constant temperature, the volume of a given gas varies inversely with the absolute pressure.
Equation: P1 x V1 = P2 x V2
If volume goes up, pressure goes down. Ex- squeezing ambu bag raises pressure and decreased volume. OR with inspiration, intrapulmonary pressure falls and volume increases. During expiration, intrapulmonary pressure increases and volume decreases.
What is Charles’ Law?
At a constant pressure, the volume of a given gas varies directly with the absolute temperature. Increasing temperature causes molecules to increase movement and thus take up more volume.
Equation: V1/T1 = V2/T2
A direct relationship means that as one increases, the other increases also.
Ex- Helium balloons shrink in the cold.
What is Gay Lussac’s Law?
Also known as the 3rd perfect gas law.
At a constant volume, the absolute pressure of a given mass of gas varies directly with the absolute temperature.
Equation: P1/T1 = P2/T2
Meaning that if temperature lowers, the pressure lowers; if temperature increases, the pressure increases. Like tire pressure in summer and winter.
Application: The lower the atmospheric pressure, the lower the boiling point.
What is Dalton’s Law of Partial Pressures?
In a mixture of gases, the pressure exerted by each gas is the same as that it would exert if it were alone in the container.
Ex- in a cylinder of air with a pressure of 100 kPa, the O2 would exert 21% or 21 kPa, and nitrogen would exert 79% or 79 kPa.
Partial pressure exerted by any single gas in a combination of gases is directly proportional to its % composition of the gas mixture.
Equation: P1 + P2 + P3 = P total
What is partial pressure?
The pressure exerted by a single component of a mixture of gases.
In the atmosphere at sea level, partial pressures are
O2, 160 mmHg (21%)
N2, 600 mmHg (79%)
Total is 760 mmHg.
In the mountains where the atmospheric pressure is 550 mmHg:
O2, 550 mmHg x 21% = 116 mmHg
N2, 550 mmHg x79% = 434 mmHg.
Application: what is the partial pressure of CO2 if its concentration in the end-tidal gases is 5%? 5% x 760 mmHg = 38 mmHg
What is Avogadro’s Hypothesis?
Equal volumes of gases at the same temperature and pressure contain equal numbers of molecules (a mole).
We have to discuss gas molecules in moles instead of masses, because gas molecules have different molecular weights. So if one mole of any gas at STP occupies 22.4 L, that means 2 gm hydrogen or 32 gm Oxygen or 44 gm CO2, or 44 gm nitrous oxide occupies 22.4 L.
What is Avogadro’s number?
6.022 x 10^23
It is the number of atoms/molecules in one mole.
What is STP?
This is standard temperature and pressure. At STP, one mole of any gas occupies 22.4 liters. STP is 0 degrees C, 760 mmHg, dry (no H2O vapor).
22.4 L = 44 g.
44g = 1 mole
Application: a nitrous oxide container is full and contains 3.4 kg of the gas. If the measurements are made at STP, what volume of nitrous oxide is obtained from this cylinder?
44g (1 mole) of N2O is 22.4 L at STP.
X liters/3400 g = 22.4 L/44 g
X = 1730 liters
What is Universal Gas Constant?
This is the gas laws combined with Avogadro’s hypothesis.
Constants: PV, V/T, P/T
PV/T = universal gas constant (nR)
PV = nRT (n is the number of moles)
Explain why the pressure gauge does not act as a content gauge for nitrous oxide.
Nitrous in a cylinder is a liquid with the pressure measuring the vapor above the liquid. Unlike O2 or air, which lowers in pressure as it empties, nitrous pressure remains constant as long as liquid remains in the container. This is why nitrous pressure will remain the same until the liquid is gone, moving from full to empty instead of gradually decreasing.
Applying avodadro’s number can be done to determine amount of nitrous left.
Universal Gas Law (ideal gas law)
PV = nRT
In application to a cylinder of gas, V is constant, R is a constant (R is universal gas constant), T is held constant, so P is directly proportional to n.
So as moles decrease, the pressure decreases.
What is critical temperature?
The temperature above which no amount of pressure can liquify a gas
This is important for nitrous
What is critical pressure?
The pressure to liquify a gas at its critical temperature.
Gas can liquify at its critical temperature but not at a temperature any higher. The critical temp of nitrous is 36.5 C. because it is stored below that temp, it is in liquid form.
What does solubility depend on?
Partial pressure of a gas
Temperature
Gas
Liquid
What is a solution?
A homogenous mixture of a solute (gas) in a solvent (liquid)
Application: we think of this in terms of the gas content in the blood through the alveoli. The pressure gradient determines how much gas goes into the blood.
What is saturated vapor pressure?
partial pressure exerted by a vapor over a liquid in a closed container when equilibrium has been met between the liquid and the vapor.
Molecules of the gas will dissolve into the liquid and an equilibrium will be attained where as many molecules of gas are entering the liquid as leaving the liquid. This is a saturated solution.
What is Henry’s Law?
At a certain temperature, the amount of a given gas dissolved in a given liquid is directly proportional to the partial pressure of the gas in equilibrium with the liquid.
ex- breathing air under pressure as scuba divers cause more nitrogen into solutions in tissues.
Henry like to scuba dive.
When you increase O2 concentration, you are increasing the partial pressure and this aids diffusion into the blood. “over pressuring”
Given an anesthesia example of Henry’s law
Increasing the concentration of isoflurane in the blood involves increasing the concentration or partial pressure. This is utilized at induction of anesthesia when a higher concentration of the anesthetic than necessary for maintenance is given as a loading dose is delivered to speed uptake. This is concentrating effect or over pressuring.
Ex- sevoflurane indiction 4-8% while maintenance is 1-4%.
Describe Le Chatelier’s Principle
A change in any of the factors in determining an equilibrium causes the system to adjust or reduce or counteract the effect of the change.
Solubility increases with decreasing temp. As the temperature of the liquid increases, the amount of gas dissolved decreases. This is because gas becomes a liquid in cooler temps, increasing the ability to dissolve in liquid, but converts back to a gas in higher temps.
What happens if a patient is cold at the end of an anesthetic?
The inhaled anesthetic will be more soluble in the blood, causing the patient to wake up more slowly.
What is solubility coefficient?
The volume of gas which dissolves in one unit volume of the liquid at the temperature concerned.
What is partition coefficient?
The ratio of the amount of substance present in one phase compared with another ( the two phases being of equal volume and in equilibrium)
How does gas affect solubility?
The solubility coefficient of a gas at body temperature explains how dissolvable a gas is.
Ex. Oxygen = 0.024 and carbon dioxide is 0.57 at body temperature. This shows that CO2 is 20 times as soluble as O2. In anesthesia, we look at the partition coefficient as a ratio and it is stated for 37 C unless stated otherwise.
Ex. if 1 liter of nitrous oxide above 1 liter of blood at 37 degrees C, the volume of nitrous oxide dissolved in the blood is 0.47 liters. So blood-gas partition coefficient is 0.47.
Order listed is important. blood-gas is 0.47 to 1, gas blood is 1 to 0.47.
What is the blood-gas partition coefficient?
This reflects the proportion of the anesthetic that will be absorbed in the blood vs the amount of anesthetic that will leave the blood to dissolve into tissues.
We can use this to compare different anesthetic agents. The lower this b-g coefficient, the faster the induction. Low b-g coefficient means poorly soluble. Equilibrium between gas and blood and brain is reached rapidly.
Inhaled agents with low solubility cause buildup in alveoli, producing the rapid induction of anesthesia.
What is the oil-gas partition coefficient?
The ratio of a gas present in oil vs in the gas state.
Indicates how efficiently a gas can access and affect the sites of action.
The higher the oil-gas coefficient (lipid-solubility) the more potent the anesthetic gas.
Fat is an important substance in cell membranes and neurons. Solubility of gases can be measured in oil, which is similar to fat in tissues.
What is the most and least potent gas? What does this mean about their solubility?
Halothane is the most potent, it has the highest oil-gas coefficient. Nitrous is the least potent, it has the lowest oil-gas coefficient.