physical pharmacy Flashcards
what is micrometric
it is science that study small particles which was introduced by Dalla Valle
it is studying the fundamental and derived property of the individual as well as the collection of the particle
the units that used to measure the micrometric particle
by 1 . micrometer 2. nanometer for more fine particle
what is the particle that in sieve range
that particle that in size of tablet granule , granules salts, and coarse powder
what is the colloidal dispersion
liquid that has particles that are really small to see through the ordinary microscope.
what is the particle that can see through the optical microscope
a particle of fine particle, pharmaceutical suspension, and colloid particle
0.5 to 10 micrometer is particle size of
particle of suspension and emulsion
size of 10 to 50 micro is size if particle
the upper limit of the coarse emulsion and aggregate suspension particle
50 to 100 micro is size of the particle
lower limit of fine powder in sieve range
150to 1000 micro is size of the particle
coarse powder range
1000 to 3360 micro is range of particle
average granule size
sieve size of the fine powder
325 to 140
sieve size of the coarse powder
100 to 18
the sieve size for the average granules size
18 to 6
what is the advantage of the micrometric
control of the particle size of the granules and the particles that will affect the chemical physical and pharmaceutical properties after the drug
believability and dosage stability and forms
what is the application of micrometric
1 release and disolutoin
2 absorption and drug action
3 dosage uniformity
4 physical stability
give how the surface area and the particle size affect on the drug action in the body
smaller particle size more surface area more releasing more solubility more dissolution more absorption more drug action
how we can improve the flow property by one method
by remove the proportional fine particle and adding coarse particle by using granulation
what the type of the powder are called in case of disperse
polydisperse
why coarse powder prefered over fine particle
coarse particle
what two important things in case if the flowability we have to keep in mind
surface area and the shape of the particle
the particle size , number and weight
how we measure the particle size
what is the method to measure the particle size
1 strock diameter
2 volumetric diameter
3 surface diameter
4 projected diameter
give the abbreviation of the measure the diameter the particle
s
how the stroke diameter measure by
by the rate of sedimentation
how the projected diameter measure
measure by the technique
why sphere particle is preferred on the rough one
because it has less interlock with the particle and less cohesive and adhesive
what glidant do
help to reduce the cohesive and adhesion
what the vibratory screener industry do
help to reduce the cohesion and adhesion between the particle
how the surface forces of the particle effects on the flow ability
electrostatic charge between the particles can decrease the flow ability and increase cohesion and interlock between the particle
how we have to reduces the electrostatic charge between the particle
reduce by altering the process condition can reduce the friction contact between the particle
three types if the density
bulk density
true density
granule density
bulk increases by
by decrease the particle size
two types of arrangement the particle
rhombohedral .. closes arrangement the porosity about 36%
a cubic arrangement where the arrangement is uniform and has more void between them porosity about 48 %
what the bulk mean
it is used to describe aby divided particle like granule powder or coarse powder used in chemistry pharmaceutical ingredient and any other application
what the difference between the true density and the bulk density
the bulk density measures the average density between the particle and includes the spaces in the volume, the volume of the particle + the volume of the granule
while the true density measures the density that occupying by the particle only without any void or spaces. the volume of the bulk - volume of the voids
what the factors that effect on the flow ability
surface texture. particle size density and porosity, and shape of the particle
what the flow property
it is used to measure the flow ability and cohesion of the particle
what is the angle of repose
used to measure the flow ability of the particle and the maximum angle at the powder particle made it
