physical pharmacy Flashcards

1
Q

what is micrometric

A

it is science that study small particles which was introduced by Dalla Valle
it is studying the fundamental and derived property of the individual as well as the collection of the particle

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2
Q

the units that used to measure the micrometric particle

A

by 1 . micrometer 2. nanometer for more fine particle

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3
Q

what is the particle that in sieve range

A

that particle that in size of tablet granule , granules salts, and coarse powder

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4
Q

what is the colloidal dispersion

A

liquid that has particles that are really small to see through the ordinary microscope.

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5
Q

what is the particle that can see through the optical microscope

A

a particle of fine particle, pharmaceutical suspension, and colloid particle

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6
Q

0.5 to 10 micrometer is particle size of

A

particle of suspension and emulsion

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7
Q

size of 10 to 50 micro is size if particle

A

the upper limit of the coarse emulsion and aggregate suspension particle

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8
Q

50 to 100 micro is size of the particle

A

lower limit of fine powder in sieve range

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9
Q

150to 1000 micro is size of the particle

A

coarse powder range

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10
Q

1000 to 3360 micro is range of particle

A

average granule size

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11
Q

sieve size of the fine powder

A

325 to 140

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12
Q

sieve size of the coarse powder

A

100 to 18

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13
Q

the sieve size for the average granules size

A

18 to 6

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14
Q

what is the advantage of the micrometric

A

control of the particle size of the granules and the particles that will affect the chemical physical and pharmaceutical properties after the drug
believability and dosage stability and forms

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15
Q

what is the application of micrometric

A

1 release and disolutoin
2 absorption and drug action
3 dosage uniformity
4 physical stability

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16
Q

give how the surface area and the particle size affect on the drug action in the body

A

smaller particle size more surface area more releasing more solubility more dissolution more absorption more drug action

17
Q

how we can improve the flow property by one method

A

by remove the proportional fine particle and adding coarse particle by using granulation

18
Q

what the type of the powder are called in case of disperse

A

polydisperse

19
Q

why coarse powder prefered over fine particle

A

coarse particle

20
Q

what two important things in case if the flowability we have to keep in mind

A

surface area and the shape of the particle
the particle size , number and weight

21
Q

how we measure the particle size

22
Q

what is the method to measure the particle size

A

1 strock diameter
2 volumetric diameter
3 surface diameter
4 projected diameter

23
Q

give the abbreviation of the measure the diameter the particle

24
Q

how the stroke diameter measure by

A

by the rate of sedimentation

25
how the projected diameter measure
measure by the technique
26
why sphere particle is preferred on the rough one
because it has less interlock with the particle and less cohesive and adhesive
27
what glidant do
help to reduce the cohesive and adhesion
28
what the vibratory screener industry do
help to reduce the cohesion and adhesion between the particle
29
how the surface forces of the particle effects on the flow ability
electrostatic charge between the particles can decrease the flow ability and increase cohesion and interlock between the particle
30
how we have to reduces the electrostatic charge between the particle
reduce by altering the process condition can reduce the friction contact between the particle
31
three types if the density
bulk density true density granule density
32
bulk increases by
by decrease the particle size
33
two types of arrangement the particle
rhombohedral .. closes arrangement the porosity about 36% a cubic arrangement where the arrangement is uniform and has more void between them porosity about 48 %
34
what the bulk mean
it is used to describe aby divided particle like granule powder or coarse powder used in chemistry pharmaceutical ingredient and any other application
35
what the difference between the true density and the bulk density
the bulk density measures the average density between the particle and includes the spaces in the volume, the volume of the particle + the volume of the granule while the true density measures the density that occupying by the particle only without any void or spaces. the volume of the bulk - volume of the voids
36
what the factors that effect on the flow ability
surface texture. particle size density and porosity, and shape of the particle
37
what the flow property
it is used to measure the flow ability and cohesion of the particle
38
what is the angle of repose
used to measure the flow ability of the particle and the maximum angle at the powder particle made it
39