physical pharmacy

Question 1

what is micrometric

Answer 1

it is science that study small particles which was introduced by Dalla Valle
it is studying the fundamental and derived property of the individual as well as the collection of the particle

Question 2

the units that used to measure the micrometric particle

Answer 2

by 1 . micrometer 2. nanometer for more fine particle

Question 3

what is the particle that in sieve range

Answer 3

that particle that in size of tablet granule , granules salts, and coarse powder

Question 4

what is the colloidal dispersion

Answer 4

liquid that has particles that are really small to see through the ordinary microscope.

Question 5

what is the particle that can see through the optical microscope

Answer 5

a particle of fine particle, pharmaceutical suspension, and colloid particle

Question 6

0.5 to 10 micrometer is particle size of

Answer 6

particle of suspension and emulsion

Question 7

size of 10 to 50 micro is size if particle

Answer 7

the upper limit of the coarse emulsion and aggregate suspension particle

Question 8

50 to 100 micro is size of the particle

Answer 8

lower limit of fine powder in sieve range

Question 9

150to 1000 micro is size of the particle

Answer 9

coarse powder range

Question 10

1000 to 3360 micro is range of particle

Answer 10

average granule size

Question 11

sieve size of the fine powder

Answer 11

325 to 140

Question 12

sieve size of the coarse powder

Answer 12

100 to 18

Question 13

the sieve size for the average granules size

Answer 13

18 to 6

Question 14

what is the advantage of the micrometric

Answer 14

control of the particle size of the granules and the particles that will affect the chemical physical and pharmaceutical properties after the drug
believability and dosage stability and forms

Question 15

what is the application of micrometric

Answer 15

1 release and disolutoin
2 absorption and drug action
3 dosage uniformity
4 physical stability

Question 16

give how the surface area and the particle size affect on the drug action in the body

Answer 16

smaller particle size more surface area more releasing more solubility more dissolution more absorption more drug action

Question 17

how we can improve the flow property by one method

Answer 17

by remove the proportional fine particle and adding coarse particle by using granulation

Question 18

what the type of the powder are called in case of disperse

Answer 18

polydisperse

Question 19

why coarse powder prefered over fine particle

Answer 19

coarse particle

Question 20

what two important things in case if the flowability we have to keep in mind

Answer 20

surface area and the shape of the particle
the particle size , number and weight

Question 21

how we measure the particle size

Question 22

what is the method to measure the particle size

Answer 22

1 strock diameter
2 volumetric diameter
3 surface diameter
4 projected diameter

Question 23

give the abbreviation of the measure the diameter the particle

Answer 23

s

Question 24

how the stroke diameter measure by

Answer 24

by the rate of sedimentation

Question 25

how the projected diameter measure

Answer 25

measure by the technique

Question 26

why sphere particle is preferred on the rough one

Answer 26

because it has less interlock with the particle and less cohesive and adhesive

Question 27

what glidant do

Answer 27

help to reduce the cohesive and adhesion

Question 28

what the vibratory screener industry do

Answer 28

help to reduce the cohesion and adhesion between the particle

Question 29

how the surface forces of the particle effects on the flow ability

Answer 29

electrostatic charge between the particles can decrease the flow ability and increase cohesion and interlock between the particle

Question 30

how we have to reduces the electrostatic charge between the particle

Answer 30

reduce by altering the process condition can reduce the friction contact between the particle

Question 31

three types if the density

Answer 31

bulk density
true density
granule density

Question 32

bulk increases by

Answer 32

by decrease the particle size

Question 33

two types of arrangement the particle

Answer 33

rhombohedral .. closes arrangement the porosity about 36%
a cubic arrangement where the arrangement is uniform and has more void between them porosity about 48 %

Question 34

what the bulk mean

Answer 34

it is used to describe aby divided particle like granule powder or coarse powder used in chemistry pharmaceutical ingredient and any other application

Question 35

what the difference between the true density and the bulk density

Answer 35

the bulk density measures the average density between the particle and includes the spaces in the volume, the volume of the particle + the volume of the granule
while the true density measures the density that occupying by the particle only without any void or spaces. the volume of the bulk - volume of the voids

Question 36

what the factors that effect on the flow ability

Answer 36

surface texture. particle size density and porosity, and shape of the particle

Question 37

what the flow property

Answer 37

it is used to measure the flow ability and cohesion of the particle

Question 38

what is the angle of repose

Answer 38

used to measure the flow ability of the particle and the maximum angle at the powder particle made it