physical and chemical methods of sterilization Flashcards
compounds have long chain hydrocarbons that are fat soluble
and charged ions that are water-soluble.
Surface active agents
these are detergents where the fat soluble portion is positively charged due to the combination with a quarternary nitrogen atom.
Cationic agents
are negatively charged agents that contain long-chain hydrocarbons
anionic agents
these act by disrupting cell membranes as well as causing precipitation of proteins and inactivation of enzymes
phenolic compounds
these are coal tar derivatives that act as disinfectants at high concentrations and as antiseptics at low concentrations.
phenolic compounds
are bactericidal and fungicidal with good activity against mycobacteria but have poor activity against spores and most viruses.
Phenols
are phenol derivatives more potent and safer than phenol.
cresols
is used as a skin disinfectant if in isopropanol solution. the aqueous preparation is used for wound irrigation. its main use is as an antiseptic hand wash
chlorhexidine
is no longer used as a disinfectant because it is toxic to human cells.
phenol
are used for topical purposes. they are effective against gram positive bacteria
chloroxylenols
is a chlorinated diphenyl which has a greater activity against gram positive bacteria similar to chloroxylenols
hexachlorophene
an organic phenyl ether, has good activity against gram-positive bacteria and a number of gram-negative including pseudomonas.
Triclosan
disorganize the lipid structure of the cell membrane, dehydrate cells, and cause denaturation and coagulation of cellular proteins.
Alcohols
used as a skin antiseptic, it is bactericidal and removes lipids from skin surfacess.
ethyl alcohol
it has a greater bactericidal activity than ethyl alcohol and is less volatile. it can be used to disinfect surfaces.
isopropyl alcohol