PHYS 3 renal transport mechanisms Flashcards
Transepithelial transport
must go across what 5 barriers?
why filter a lot of blood then reabsorb 99% of it?
why not filter and excrete the 1% that needs to be eliminated?
Draw the overview of reabsorption of the nephron
essentials of the proximal tubule
reabsorbs what?
keh element in proximal tubule reabsorption is?
changes in concentration in proximal tubule
special feature?
glucose and AA?
Na?
H2O?
what increases?
Na-K-ATPase in PCT
what is the mechanism of action?
ways to transport?
ATPases location?
route specifications
in order to reach the blood reabsorbed substances must either?
Transcellular vs paracellular route
what does most of the energy used for reabsorption go towards?
what route will Na usually go down?
Transporting Na?
can be broken down to 3 steps?
what is used to get Na into the tubule cells?
this is important for what other absorption?
what two questions does this bring up?
How is bicarbonate reabsorbed?
start with?
transporters?
H?
Carbonic anhydrase is key
Chloride reabsoption
what drives this?
water movement and paracellular movement
when would there be movement vs when would there not?
Water and transcellular route
what help?
net water permeability of renal tubule is determined by?
proximal tubule?
ascending limb?
Collecting duct?
Glucose
reasorbed how?
specific mechanism
diabetes and glucose transport
transport maximum
what is it?
in reference to glucose?
actual numbers?
Descending loop of Henle
permeable to what? what percent?
how does it move?
impermeable?
causes?
ascending reabsorbs what?
doesnt reabsorb?
thick ascending does what?
has what?
what does furosemide do?
what transporter transports what on the apical membrane (thick limb)?
how about the basolateral?
what about charge?
what other things will be reabsorbed?
what can cause problems in reabsorbing these?
difference in filtering in a normal/high potassium diet and a low potassium diet/potassium depletion
countercurrent multiplier
loop of Henle
DIstal tubule
normally reabsorbs what? how much?
major mechanism apical and basolateral?
how much of the originally filtered Na and H2O remain here?
impermeable to?
What pharmaceutical action can be done?
Collecting ducts
reabsorption at this point?
ADH?
Aldosterone?
how much Na usually leaves in urine?
what can be a big problem?
Aldosterone
what causes release?
what mechanism would either cause aldosterone to be released?
inhibiting transport?
what will do this?
3 examples?
Disturbances in multiplying
H2O deficit
Disturbance in multiplying
Excess water
