PHYS 3 renal transport mechanisms

Question 1

Transepithelial transport

must go across what 5 barriers?

Answer 1

Question 2

why filter a lot of blood then reabsorb 99% of it?

why not filter and excrete the 1% that needs to be eliminated?

Answer 2

Question 3

Draw the overview of reabsorption of the nephron

Answer 3

Question 4

essentials of the proximal tubule

reabsorbs what?

keh element in proximal tubule reabsorption is?

Answer 4

Question 5

changes in concentration in proximal tubule

special feature?

glucose and AA?

Na?

H2O?

what increases?

Answer 5

Question 6

Na-K-ATPase in PCT

what is the mechanism of action?

Answer 6

Question 7

ways to transport?

ATPases location?

Answer 7

Question 8

route specifications

in order to reach the blood reabsorbed substances must either?

Answer 8

Question 9

Transcellular vs paracellular route

Answer 9

Question 10

what does most of the energy used for reabsorption go towards?

what route will Na usually go down?

Answer 10

Question 11

Transporting Na?

can be broken down to 3 steps?

Answer 11

Question 12

what is used to get Na into the tubule cells?

this is important for what other absorption?

what two questions does this bring up?

Answer 12

Question 13

How is bicarbonate reabsorbed?

start with?

transporters?

H?

Answer 13

Carbonic anhydrase is key

Question 14

Chloride reabsoption

what drives this?

Answer 14

Question 15

water movement and paracellular movement

when would there be movement vs when would there not?

Answer 15

Question 16

Water and transcellular route

what help?

Answer 16

Question 17

net water permeability of renal tubule is determined by?

proximal tubule?

ascending limb?

Collecting duct?

Answer 17

Question 18

Answer 18

Question 19

Glucose

reasorbed how?

specific mechanism

Answer 19

Question 20

diabetes and glucose transport

Answer 20

Question 21

transport maximum

what is it?

in reference to glucose?

actual numbers?

Answer 21

Question 22

Descending loop of Henle

permeable to what? what percent?

how does it move?

impermeable?

causes?

Answer 22

Question 23

ascending reabsorbs what?

doesnt reabsorb?

thick ascending does what?

has what?

what does furosemide do?

Answer 23

Question 24

what transporter transports what on the apical membrane (thick limb)?

how about the basolateral?

what about charge?

what other things will be reabsorbed?

what can cause problems in reabsorbing these?

Answer 24

Question 25

difference in filtering in a normal/high potassium diet and a low potassium diet/potassium depletion

Answer 25

Question 26

countercurrent multiplier loop of Henle

Answer 26

Question 27

DIstal tubule normally reabsorbs what? how much? major mechanism apical and basolateral? how much of the originally filtered Na and H2O remain here? impermeable to? What pharmaceutical action can be done?

Answer 27

Question 28

Collecting ducts reabsorption at this point? ADH? Aldosterone? how much Na usually leaves in urine? what can be a big problem?

Answer 28

Question 29

Aldosterone what causes release? what mechanism would either cause aldosterone to be released?

Answer 29

Question 30

Answer 30

Question 31

inhibiting transport? what will do this? 3 examples?

Answer 31

Question 32

Disturbances in multiplying H2O deficit

Answer 32

Question 33

Disturbance in multiplying Excess water

Answer 33