Phosphodiesterase Inhibitors

Question 1

Phosphodiesterase Inhibitors

Classification-

Answer 1

-Second class of meds that act as INOTROPIC agents

Question 2

Phosphodiesterase Inhibitors

Names (Type)-

Answer 2

-Inamrinone: approved only for use in patients with HF that has NOT responded to digoxin, diuretics, or vasodilators

Question 3

Phosphodiesterase Inhibitors

Name (Type)-

Answer 3

• Milrinone (P): SHORT-TERM management of HF in patients who are receiving digoxin and diuretics
• common in hospital settings

Question 4

Phosphodiesterase Inhibitors

MOA-

Answer 4

-Blocks the enzyme Phosphodiesterase= increased myocardial cell cyclic adenosine monophosphate (cAMP) = increased calcium levels= stronger contraction and prolonged response to to sympathetic stimulation. Also directly relaxes vascular smooth muscle

Question 5

Phosphodiesterase Inhibitors

Indications-

Answer 5

SHORT-TERM treatment of HF in patients unresponsive to digitalis, diuretics, or vasodilators

Question 6

Phosphodiesterase Inhibitors

Contraindications-

Answer 6

• Allergy
• Severe aortic or pulmonic dz
• MI
• Fluid Volume Deficit
• Ventricular arrhythmias (complicate/exacerbate these)

Question 7

Phosphodiesterase Inhibitors

Cautions-

Answer 7

• Pregnancy/Lact

- Elderly (increased risk of drug effects)

Question 8

Phosphodiesterase Inhibitors

Adverse Effects-

Answer 8

-Arrhythmias
-Hypotension
-N/Vomiting
-Thrombocytopenia
-Pericarditis
-Pleuritis
-Fever
CP
-Burning @ injection site

Question 9

Phosphodiesterase Inhibitors

Drug-Drug

Answer 9

Furosemide (CANNOT MIX in same bag/syringe)

*can take together, just can’t physically mix!)

Question 10

Phosphodiesterase Inhibitors

Implementation-

Answer 10

• Protect drug from light
• Monitor pulse and BP frequently during admin.
• Monitor daily weights
• Monitor platelet count before and during therapy
• Have code cart on standby