Phenytoin June 24

Question 1

Phenytoin Indications?

Answer 1

• Tonic-colonic - Focal - Status epilepsy - Prevention of seizure during surgery

Question 2

Phenytoin Therapeutic range?

Answer 2

• 10-20 mg/l - 40/80 mmol/l

Question 3

Phenytoin Mechanism of Action (M.O.A)?

Answer 3

• Na+ Channel blocker prevents firing of nerve signals.

Question 4

Phenytoin Contraindications?

Answer 4

• Acute porphyria’s [liver disorder, dark urine] - Blood

Question 5

Phenytoin BF (Breastfeeding)?

Answer 5

• Safe

Question 6

Phenytoin Pregnancy?

Answer 6

• Avoid

Question 7

Phenytoin MHRA warning?

Answer 7

• Risk of suicide - Injection risk of death - Maintain brand.

Question 8

Phenytoin Monitor?

Answer 8

• Enzyme inducer will decrease plasma concentration of other drugs - Check HLAb* 1502 Alle before start - Risk of JS - LFT

Question 9

Phenytoin Side effects?

Answer 9

• Avoid IM, always oral or IV - P…P45 inducer - H…Hirsutism – Thick hair growth face in women - E…Enlarged gums - N…Nystagmus

Question 10

Phenytoin Drug interactions?

Answer 10

• Amiodarone