Phenytoin - davis

Question 1

Pheyntoin salt fator of 1

Answer 1

tablets and suspension

Question 2

phenytoin salt factor of 0.92

Answer 2

capsules and iv

Question 3

iv max infuse rate

Answer 3

50mg/min

Question 4

po max ingestion rate

Answer 4

400 mg po every 2 hours

Question 5

protein bound?

Answer 5

yes to albumin

Question 6

level of protein-bound

Answer 6

10- free
90 - bound

Question 7

therapeutic range of phenytoin

Answer 7

40-80 mewmol/l

10-20 mg/l

Question 8

when do we conside rhypoalbuminemia?

Answer 8

when less then 3.2 g/dl

Question 9

dl to ml

Answer 9

1 dL= 100mL

Question 10

what should we be careful about co-adminstering it with?

Answer 10

antacids could decrease absorption

Question 11

what is it distribution of phenytoin like

Answer 11

widely distributed all over

Question 12

lab values in phenytoin acid or salt?

Answer 12

acid

Question 13

conversion fro mew mol/l to mg/l

Answer 13

mew mol/l = 3.96 X mg/l

Question 14

what disease states should we be aware of for altering phenytoin levels

Answer 14

renal failure, hypoalbuminemia, liver disease

Question 15

what drugs can alter valproate levels?

Answer 15

valproate acid or aspirin

Question 16

main points to know about valproate acid use

Answer 16

therpautic level - 50 mg/L to 100 mg/L

at 70mg /l can decrease serum phenytoin levels by 40%

causing increased free fraction and increased elimination

Question 17

what populations can u expect hypoalbunmeia in?

Answer 17

pregnancy or gernatics

Question 18

ESRD details on what it does to phenytoin

Answer 18

less albumin and accumulation of p-hPPh( metabolite that diplaces phenytoin)

Question 19

how is pheyntoin metabolixed

Answer 19

95% metabolized by CYP 450
via hydroxylation and glucuronadation

Question 20

how is heyntoin eleiminated

Answer 20

5% unchange in urine

cl refelct amount/time not volume over time

Question 21

how long till css is achived

Answer 21

allow one week

Question 22

what is the Css target

Answer 22

15mg/L

Question 23

Vmax

Answer 23

7mg/kg/day

Question 24

km

Answer 24

4 mg/L

Question 25

Vd

Answer 25

0.63 X weight in kg

Question 26

nennates VD

Answer 26

1

Question 27

when should we take through levels

Answer 27

idealyy in morning before next dose

Question 28

typical Loading dose

Answer 28

10-15 mg/kg

Question 29

population with lower Cl

Answer 29

infants and geriatric

Question 30

population with high cl

Answer 30

children, pregenancy (also has incteased absorption - monitor!!!@)

Question 31

when is a pateint calssfied obese

Answer 31

when ideal body weight is more then 20 of actual

actual - ideal / ideal

Question 32

having a lowever km means what for the tehrpautic window

Answer 32

narower therpautic window