Phenotypes And Chromosomes

Question 0

Follicular

Answer 0

Cd10+

T(14:18)

Oncogene BCL2

Question 1

CLL/SLL

Answer 1

Cd5+
Cd20 dim
Cd19
Cd23*

No cytogenetic abnormalities

Question 2

Mantle cell

Answer 2

(11;14)
Cd5+
Cd20+
Cd23- 
Cd10-
FMC7+

Cyclin d1+
T(11:14)
Oncogene cyclin d1

Question 3

Marginal zone

Answer 3

Cd20+
T(11;18)
Oncogene AP12-Malt 1
Cd 43+

Question 4

Lymphoplasmacytic lymphoma

Answer 4

Cd20+
Cd25+
Cd38+
T(9;14)

Question 5

Hairy cell

Answer 5

Cd20+
Cd11c+
Cd25+ *
Cd103+ *
Weak cyclin d1
Tx: cladribine or pentostatin/r

Question 6

DLBCL

Answer 6

Cd5 rare
Cd10 +\-
Cd20 dim
T(14;18), t(3;14), t(3;v)
Rare t(8;x)

Oncogene bcl2 bcl6 cMyc

Question 7

PMBCL

Answer 7

Cd10 +/-
Cd20+
Cd30+/-

T(16;x)

Oncogene CIITA

Question 8

Burkitt lymphoma

Answer 8

Cd10+ 
Cd20+
Tdt-
T(8;14), t(2;8), t(8;22)
Oncogene cMyc
Bcl 2 -

Question 9

Anaplastic large cell lymphoma, alk+

Answer 9

Cd30+,cd2+/-, cd3 +/-, ema+

T(2;5)

Oncogene alk

Question 10

Anaplastic large cell lymphoma, alk-

Answer 10

Cd30+,cd2+/-, cd3 +/-, ema

T(6;7), (p25.3;q32.3)

Oncogene DUSP22

Question 11

Primary cutaneous ALCL

Answer 11

• Primary cutaneous Cd30+ T cell
• Localized- surgery with/out radiation
• cd4+
• cd5+
• granzyme B
• EMA -
• ALK -

Question 12

CLL common aberrations

Answer 12

Deletion 13 - favorable
Deletion 11
Deletion 17 - worst prognosis

Question 13

Multiple myeloma

Answer 13

Good : (14;16) (4;14)

Bad : (11;14)