Pharmcology Flashcards
PUD
قرحة المعده والاثني
محتاجين نمنع من انتاج احماض المعده
نزيد من المخاط الغني ب HCO3 -
مضاد الحموضه ومعادلتها
اسماء الادويه التي تمنع افراز الاحماض
المتدين / الزول /براون
براك ولله الحمد صار (متدين وزول )
Tidine - pine - zole
PPI
Enteric coating
Activated by 1/2 cell pH (-ve irr +cov bond with K/H sys P-pump
Zepine = need high dose not favourable serious s/e
Lano Pento esmo Oma = IV Ava
Nezi only not IV AVa
Ran not lv bolus 💥❤️‼️🔥
Cemi sexual aff male (🫣gyncom -imp🧍) / female (g+r)
NSAID + H-pylori
Ulcers
S/E
Anti secretory drug
Cemi s/e
sexual hormonal abnormality male / female
I milk 🥛
CNS effect
-ve CYPTp450 (which increase the concentration of the intakes drug )
Ran ❤️☄️🔥‼️ hypo -Brady ❤️🔥
Ostoporsis - bone 🦴 💥🧎 after long term use > 1yr
Due to بس مافي
B12 -Ca-Fe-Mg
اسهال
IDA
CNS effect
Osteoporosis
C/D long term especially with female menopause >50yr
DDI ppi
kento cona zole | decrease absorption
Sucralfate need acidic ph to promote their effect (affect MOA) anti secretory gastric acid
Ome Esmo lano deoxy Lano zole -ve CYT2c19 specific liver enzymes (important with patient who receive anti platelets agent 🔦cliopedgrel suggest to use R-zole -panto-zole
Zole effect zole
Zole affect Sur
Zole affect Clio specific
All CSZ derivatives
Zole + tidin all affect abs Z+ moa of S
Increases mucosal💧(protection-repair 👨🔧— BF)
M is Misprostole
Bis (Muth)
Sucralfate
Effect
3- sucrose Increase mucous GEL + ALOH —> constipation + C/I RF S/E
2- increase mucous protection ^^Hco3- bi anti (h-d)
1- C/I Pre lady Diarrhea effect bleeding 🩸 ^^ contr of Uterine SMC
S/E of BIS muth
Reversible black Discolour (STT)
Effect
3- sucrose Increase mucous GEL + ALOH —> constipation + C/I RF S/E
2- increase mucous protection ^^Hco3- bi anti (h-d)
1- C/I Pre lady Diarrhea effect bleeding 🩸 ^^ contr of Uterine SMC
S/E of BIS muth
Reversible black Discolour (STT)
Teeth +tongue +stool
S/E of bismuth
STT black discolouration
Antiacids
W-base +Acid to neutralise it 1- increase PH level ❎ pepstin by salt production 2- to form water 💦 & salt 3- Increase LES pressure **Alginates acid ❇️
Effect on existing problem not appropriate treatment
It a symptomatic relief for existing Ulcer - GERD
Ex:- NaHco3 - CaHco3 /Al(OH)3 - Mg(OH)2
GIT ABSNa+Ca/local effect OH rich
Effect C02 Bleach & Fluteching 🤢 tx : mixed with semithioCOne
Mixed OF AL +Mg to ❌S/E
DDI use before Meal 🥘 (30min)
Gavi-scon :- suss NA/CA +Aliginic acid
Tab - AL/Mg + ALiginic acid
Uses PUD - GERD - Dysoepsia
Aliginic acid
Anti gastric reflux through forming viscous block layer on the top of G-epithelium
Imp : GERD
1line of treatment 4 therapy
Pylorus
metro 🚋 🚌
PPI
3
AC PPI
Resistance of H.pylori —> to clarthomycin
الاوديه المضاده للتقيء “صدمة “
5HT3R antagonist
D2R antagonist
M1R antagonist
H1R antagonist
Anti (S-D-M-H)
Setron = anti Sertonin R 5HT3R blockers (
5HT3R blockers in P-CTZ -Vc sites
Ondan / Grani
D2 R in CTS
Met (Amide)
Parkinson + EPS + Hyper-pro-lactinemia as as/e -ve D2 BG & Hypothalamus due Amide can cross BBB
Increase motility- evacuation- tone of LES
C/l in children 👦🏻
Release ACH - Stimulus 5HT4 R
Do-perd-one
Do relat to dopamine 2 R blocker
Can’t cross BBB
Affect only D2R on hypothalamus —> hyper-pro-lactinlinemia
Fatal -QT - prolongation especially with itrao-keto+zole /+erythromycin
D2 blocker have - pro-kinetic effect 1-ACH 2-MET 3-one -ve@1blocker
Bf meal 30min givin
Granisetron can used as patches “”
Both 5HT3 blockers & D2R blockers antiemetic
CINV
RINV DINV PONV 1line D2R -ve especially metcloprAMIDE >DOMperdone
CINV 1LINE 5HT3 blockers
Moring skiness in pregnant lady 🤰ass with Doperdone as 2linechose
GERD -DM GASRIO PARSIS WITH D2R -ve Dm is with D MET (AMIDE )
Bf endoscope 👁️🗨️ MET to 🔴⤴️⤴️reduce GAG reflex
Bf emergency 🚨 surgery & labor MET ( withGA )
DOC in D2R with Childern & pregnant is Dom-perd-one
M1 R -ve
ex scopolamine
M1 R -ve in vc + ves
Motion sickness 🔵 vertigo للوقايه
H1 r zINEvs H2 r tidINE
Zine cyclozINE + MecLizINE
للوقايع والعلاج من الدوار M-Sickness
1line PONV From H1Rb cyclozINE
1ANTI histamine Blocker
With Pregant moring sickness — MecLizINE With pyr VITB6
MecLizINE +VIT b6 NVP
Anti emtic
If CINV
GLUCOCORTICOID +NK1B(prepitent) IN COMBINATION ( DEXOMETHSONE ) SYMPTOMATIC RELIF
Cannabinoids + SEVERE CINV+RINV IN COMBINATION THRAPY
USE IN COMBINATION
B6 PYRIDOXAL ORAL + PREGNANT 🤰 M-SICKENINS.
Motion sickness (M+H) vc+vs blocker receptor (PONV)
Morning sickness (MHRB + D2R ) DH (PONV)
CINV /RINV 5HT3 +CANNbnoids + D2RB
GC + CANn + 5HT3 RB + D2RB + NK1RB
