Pharmacy Questions Flashcards

1
Q

What is the principle organ responsible for biotransformation (metabolism) of drugs

A

Liver

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2
Q

What is the principle organ responsible for excretion of drugs

A

Kidneys

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3
Q

X with Y

Y with Z

A

Xylazine reversed with Yohimbine

Yohimbine treats amitraZ toxicity

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4
Q

Which animals are most sensitive to Xylizine?

A

Cattle

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5
Q

Xylizine is used as an emetic in what animal?

A

Cats

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6
Q

What drug is associated with cartilaginous lesions in joints of growing equine/canines?

A

Quinolones (Baytril)

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7
Q

Enrofloxicin is approved primarily for what issues?

A

Skin, urinary, and respiratory infections in dogs and cats

Bone and other infections in additional species

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8
Q

4 adverse effects of Acepromazine

A

Decreases seizure threshold
Can be overly sensitive to giant K9 breeds
Causes HYPOtension
Penis protrusion in equine

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9
Q

Glycopyrrolate would more likely be used over Atropine due to ___ and is less likely to cause ___ while suppressing ____

A

Its lower onset and longer duration
Tachycardia and Cardiac arrhythmias
Salivation more effectively

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10
Q

Anticholinergics are used to counteract ____ and ____

A

Bradycardia and hypersalivation

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11
Q

Etomidate is not widely used due to __ and ___

A

Higher cost and adverse effects

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12
Q

Adverse effects of Etomidate

A

Vomiting, Muscle movements, sneezing, and excitement during induction and recovery.

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13
Q

Docusate is a ___

A

Stool softener

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14
Q

Ionic (charged) forms of drugs and membranes

A

Do no pass through easily

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15
Q

Most drugs with poor lipid solubility ___ cell membranes

A

Cannot pass through

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16
Q

Lipophilic

A

Drug that tends to combine with or dissolve in lipids or fats easily

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17
Q

Hydrophilic

A

Drug that tends to mix with, dissolve in, or be wetted by water

18
Q

Long term use of glucocorticoids side effects

A
increase in thirst/urination
increased susceptibility to UTIs and other infections
Increased panting
muscle atrophy and hind limb weakness
GI ulcerations
Cushing's disease
19
Q

What is the first line anti-convulsant?

What is a contraindicator?

A
Phenobarbital 
Liver disease (causes hepatotoxicity)
20
Q

Long term use of Phenylbutazone can cause ulcers in the ___ in dehydrated horses and are difficult to treat.

A

right dorsal colon

21
Q

What is Methoprene?

A

A synthetic insect growth regulator and is classified as a terpenoid.

22
Q

Methoprene is used in ___ products.

A

Topical flea control

23
Q

Methoprene works by ___.

A

Interfering with normal maturation process. Makes it impossible for insects to mature to adult stages.

24
Q

Aminoglycosides are mainly used for what type of organisims?

A

Gram-negative

25
Q

Examples of Aminoglycosides

A
Strepomycin
Neomycin
Kanamycin
Amikacin
Gentamicin
26
Q

Adverse effects of Aminoglycosides

A

Nephrotoxicity (renal)
Ototoxicity
Neuromuscular blockage

27
Q

Adverse effects of tetracyclines

A
Chelation of calcium in teeth inhibiting calcification 
Potentially nephrotoxic (except for Doxycycline)
28
Q

What drug is used to treat ethylene glycol toxicity?

A

Fomepizole (4-MP)

29
Q

Early signs of ethylene glycol poisoning occur within ___ to ___ postingestion.

A

30 min. to 12 hours

30
Q

Sulfonamides tend to be associated with ___ or allergic reactions

A

Hypersensitivity

31
Q

Most commonly used NSAID in large animals?

A

Phenlybutazone

32
Q

Arsenic can be found in ___ causing GI upset, vomiting, diarrhea, weakness, etc.

A

ant baits

33
Q

What analgesic drug combination should not be used together in dogs/cats due to the risk of GI ulcerations?

A

Meloxican and dexamethasone

NSAIDs & Steroids should not be used together

34
Q

Doxorubicin is well known for what possible side effect in dobermans, great danes, rottweilers, and boxers?

A

Cardiotoxicity

35
Q

Morphine side effects in dogs

A
Vomiting
Puritits
Constipation
Sedation
Dysphoria 
Bradycardia
Miosis
36
Q

What is used for Cushing’s treatment in horses?

A

Pergolide

37
Q

Rabbits, hamsters, and other rodents are sensitive to most antibiotics due to ____

A

Disruption of their normal gut flora

38
Q

Dogs tend to get ___ on morphine while cats and horses tend to get ___.

A

miosis (small pupils)

mydriasis (enlarged pupils)

39
Q

What happens if you inject Phenylbutazone IM or SQ in a horse?

A

Swelling, necrosis, and sloughing

40
Q

Antibiotics that are safe for small pets like rabbits, hamsters, and guinea pigs

A

Trimethoprim Sulfa
Chlorampenicol
Enrofloxicin