Pharmacy Flashcards
Why is pyridostigmine used in Myasthenia gravis and Donepezil used in Alzheimer’s?
Both acetylcholinesterase inhibitors
Pyridostigmine works peripherally at the neuromuscular junction
What are contra-indications to Donepezil?
- Bradycardia
- Severe hepatic impairment
- Allergic reactions
What medication can be used to manage severe psychological and behavioural symptoms of Alzheimer’s?
Risperidone- atypical antipsychotic
Blocks dopamine D2 receptors: Reducing psychotic symptoms.
Blocks serotonin 5-HT2A receptors: Associated with fewer extrapyramidal side effects compared to first-generation antipsychotics.
What medication can be used for Alzheimer’s disease if there are GI side effects?
Transdermal Rivastigmine patch
Class, indication, side effects, impact on falls and interactions of Haloperidol
- Typical antipsychotic
- Schizophrenia, agitation and delirium
- Extrapyramidal symptoms, sedation, neuroleptic malignant syndrome, QT prolongation
- Increases fall risk due to sedation, rigidity and orthostasis.
Are patients with Lewy body dementia as responsive to Levodopa as patients with parkinson’s disease?
No
Side effects of SSRIs
Upper GI bleeding (need PPI protection)
Side effect of Citalopram
QT prolongation
What class of drug is Oxybutynin?
Anti-muscarinic
What is Oxybutynin used for?
Overactive bladder
What are the side effects of Oxybutynin?
- Dry mouth
- Constipation
- Blurred vision
- Dizziness
- Urinary retention
- Nausea
- Cognitive impairment
What drug class if Solifenacin?
Antimuscarinic
What drug class is Mirabegron?
Beta 3 adrenergic agonist
What is Mirabegron used to treat?
Overactive bladder
What are the side effects of Mirabegron?
- Hypertension
- Headache
- Dry mouth
- Constipation
- Dizzinesss
- UTI
- Tachycardia
