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Reproduction Final > Pharmacotherapy of Infertility > Flashcards

Pharmacotherapy of Infertility Flashcards

1
Q

Clear Blue Fertility Monitor detects?

A

LH and estrogen hormones

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2
Q

Clear Blue Fertility Monitor general

A

99% accurate
Should be off oral contraceptives for 2 cycles
Use first urine sample of the morning!

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3
Q

Fertility scope is what kind of test and what does it monitor?

A

Saliva based

Estrogen levels

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4
Q

Fertility Scope General

A

Requires visual interpretation
98% accurate
OK in women with irregular periods

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5
Q

Fertility Scope can be affected by

A 
Eating
Drinking
Brushing teeth
Smoking within 2-3 hr
Any residue of food or alcohol
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6
Q

First Response Fertility is what kind of test and what does it monitor?

A

Urine

FSH on day 3 of menses

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7
Q

First Response cannot be used if

A

Taken oral contraceptive or hormonal medication within 60 days

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8
Q

First Response Daily Ovulation Test is what kind of test and what does it monitor?

A

Urine

LH surge

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9
Q

First Response Daily Ovulation Test General

A

Do not open the foil pouch until containing strips until DAY 5 of period
Must be used within 30 days after opening
Test around the same time every day

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10
Q

OvWatch is what kind of test and what does it monitor?

A

Wrist-mounted

Transdermal Chloride

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11
Q

OvWatch general

A

Cl surge = fertile window
Notifies 4 days before ovulation (high probability of pregnancy)
EXPENSIVE
No OCs
Begin wearing within 3 days start of menses

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12
Q

Treatment of Infertility

A

Ovulation induction or controlled ovarian hyperstimulation

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13
Q

Goals of treatment

A

Achieve pregnancy
Birth of a healthy infant
Minimize the stress, physical discomfort, financial cost and risk

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14
Q

Non-Steroidial Estrogen Receptor Blocker Example

A

Clomiphene

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15
Q

Clomiphene MOA

A

Inhibit estrogen binding and prevents normal feedback inhibition, increasing LH and FSH

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16
Q

Clomiphene Side Effects

A

Hot flashes, ab discomfort, multiple prego, n/v/d

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17
Q

Clominphene place in therapy

A

First line for ovulation induction with timed intercourse, PCOS and women with normal GnRH production

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18
Q

Counseling Points for Clominphene

A

Patient should have a blood check of progesterone around day 21 to detect if an increase has occured

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19
Q

Aromatase Inhibitor

A

Letrozole

20
Q

Letrozole MOA

A

Inhibits conversion of testosterone to estrogen increase release of FSH and LH

21
Q

Letrozole place in therapy

A

Ovulation stimulation

Clomiphene failure

22
Q

Monitoring with Clomiphene and Letrozole

A

Via Ovulation prediction kits of ultrasounds

23
Q

hMG

A

Repronex
Menopur
75 IU FSH and LH

24
Q

HP-FSH

A

Bravelle

75 IU FSH

25
Q

Follitropin-alpha and beta

Lutropin alpha

A

Gonal F and Follistim AQ both are 75 IU FSH

Luveris is 75 IU LH

26
Q

hCG Brand Names

A

Pregnyl
Novarel
Ovidrel
- Usually an additive therapy

27
Q

hCG MOA

A

Supplement LH to mimic LH surge

28
Q

hCG Side Effects

A

Headache, irritability, restlessness, fatigue, edema

29
Q

hCG Place in Therapy

A

Female: ovulation induction and correct lack of LH surge
Male: Spermatogenesis if with hypogonadotropic hypogonadism

30
Q

Lupron

A

leuprolide
GnRH Agonists
Injection

31
Q

Zoladex

A

Goserelin
GnRH Agonists
Implant

32
Q

Synarel

A

Nafarelin
GnRH Agonists
Nasal Spray

33
Q

Lutrepulse

A

Gonadorelin acetate
GnRH Agonists
Pump

34
Q

GnRH Agonists MOA

A

Stimulate gonadotropin release form pituitary

Few weeks later, shuts it down

35
Q

GnRH Agonists Side Effects

A

Vaginal bleeding
Breast tenderness
Hot flashes, headaches, vaginal dryness

36
Q

GnRH Agonists Place in Therapy

A

Anovulation due to GnRH deficiency
PCOS
Increase Sperm Count

37
Q

Antagon

Cetrotide

A

Ganirelix
Cetrorelix
GnRH Antagonists

38
Q

GnRH Antagonists MOA

A

Decrease FSH and LH via competition for receptors

39
Q

Antagon should be used with

A

hCG

40
Q

GnRH Antagonists Place in Therapy

A

Suppress premature LH surge and premature ovulation

41
Q

OCs as hormonal supplements

A

Before fertility treatment to induce withdrawal bleeding

Reduces androgenicity and ovarian cysts

42
Q

Estrogen use

A

Increase volume and thin cervical mucus and facilitate growth of endometrium

43
Q

Progesterone use

A

Maintain endometrium

Dosing not user friendly

44
Q

When would you use a dopamine agonists?

A

Hyperprolactinemia

45
Q

Drugs for ovulation induction/

A

Clomiphene

+/- gonadotropins

46
Q

Drugs for controlled ovarian hyperstimulation

A

Gonadotropins
+/- GnRH agonists OR antagonists
hCG

Reproduction Final (6 decks)

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