Pharmacotherapy exam 3

Question 1

Phentermine/Diethylpropion MOA

Answer 1

Sympathomimetic amine; reduces food intake

Question 2

Phentermine/Diethylpropion Effect on weight

Answer 2

3-3.6 kg at 6 months

Question 3

Phentermine/Diethylpropion Side effects

Answer 3

Heachache, insomnia, irritability, palpatations, nervousness

Question 4

Orlistat MOA

Answer 4

Lipase inhibitor; affects fat absorption

Question 5

Orlistat Effect on Weight

Answer 5

2.59 kg at 6 months, 2.89 kg at 1 year

Question 6

Orlistant Side effects

Answer 6

Diarrhea, bloating, flatulence, abdominal pain, and dyspepsia

Question 7

Locaserin MOA

Answer 7

Selective serotonin 2C receptor agonist

Question 8

Locaserin Effect on weight

Answer 8

5.6 kg at 1 year

Question 9

Locaserin Side effects

Answer 9

Headache, dizziness, and nausea

Question 10

Phentermine/Topiramate CR MOA

Answer 10

1. Reduces food intake
2. Promotes satiety
3. Possibly increases metabolic rate

Question 11

Naltrexone CR/Welbutrin CR MOA

Answer 11

1. Synergism via POMC activation

2. Appetite suppression and reward center effects

Question 12

Naltrexone CR/ Welbutrin CR MOA

Answer 12

6.5 kg at 1 year

Question 13

Liraglutide MOA

Answer 13

1. GLP-1 central appetite suppresion

2. Decreased gastric motility

Question 14

Liraglutide Effect on weight

Answer 14

5.9 kg at 1 year

Question 15

Liraglutide side effects

Answer 15

N/V/D, constipation, flatulence

Question 16

Phentermine Contraindications

Answer 16

1. Advanced arteriosclerosis
2. Hyperthyroidism
3. Glaucoma
4. Moderate HTN
5. Pulmonary HTN

Question 17

Phentermine/Topiramate CR

Answer 17

1. Pregnancy (need negative preg tests monthly)
2. Glaucoma
3. Hyperthyroidism
4. Concomitant use of MAO inhibitors

Question 18

Naltrezone SR/Bupropion SR Contraindications

Answer 18

1. Uncontrolled HTN
2. Pregnancy
3. Seizure disorder
4. Chronic opioid use
5. MAOI use

Question 19

Liraglutide: Contraindications

Answer 19

1. History of Thyroid CA

2. Pregnancy