Pharmacopeia

Question 1

Midazolam
Class, Chemistry, ROA

Answer 1

Sedative
Benzodiazepine
Oral, IV, IM, IT, Epidural, Buccally, Nasally

Question 2

Midazolam
Absorption

Answer 2

40% bioavailability, significant first pass metabolism

Question 3

Midazolam - Presentation

Answer 3

Clear, colourless solution
1mg/ml in 5ml ampoule
H20 Soluble
ph solution 3.5 –> <4 imidazole ring open - H2O soluble
ph>4 imidazole ring closed, lipid soluble
Ph 7.4 89% unionized

Question 4

Midazolam dose

Answer 4

0.1-.2 mg/kg , depends on the indication
1. anxiolysis 20%
Sedation 50% receptor occupied
3. Unconsciousness >60% receptor occupied