pharmacology_block_3_quizzes_20151122010426 Flashcards

1
Q

Isoflurane and halothane are good examples of volatile liquid general anesthetics. Which of the following statements best compares or contrasts their actions?A. Halothane is associated with a higher risk of hepatic toxicity, especially in patients who have been anesthetized with this drug before.B. Halothane and Isoflurane typically raise BP, via direct vasoconstrictor effects.C. Isoflurane sensitizes the myocardium to the arrhythmmogenic effects of catecholamines much more than halothane does.D. Isoflurane prolongs the QT interval (ventricular repolarization), and is associated with a much higher risk of causing potentially fatal ventricular tachyarrhythmias, than halothane.E. Use of Isoflurane for balanced anesthesia requires adjunctive use of nitrous oxide and neuromuscular blockers, use of halothane does not.

A

A. Halothane is associated with a higher risk of hepatic toxicity, especially in patients who have been anesthetized with this drug before.

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2
Q

A patient has been taking an oral monoamine oxidase inhibitor MAOI, but the fact is unknown to the health team who is now taking care of her, for unrelated medical conditions in the hospital. The patient receives a drug that leads to a fatal response characterized by profound fever, delirium, psychotic behavior, and status epileptics. It was found to have occurred because of an interaction with the MAO. Which of the following drugs, or class of drugs, was most likely administered by the attending health team?A. PehytoinB. DiazepamC. MeperidineD. A BarbiturateE. Morphine

A

C. Meperidine

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3
Q

A young boy is diagnosed with asthma. His primary symptom is frequent cough, not bronchospasm or wheezing. Other asthma medications are started, but until their effects develop fully we wish to suppress the cough without running a risk of suppressing ventilatory drive or causing sedation or other unwanted effects. Which of the following would best meet these needs?A. DextromethorphanB. CodeineC. HydrocodoneD. DiphenhydramineE. Promethazine

A

A. Dextromethorphan

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4
Q

A 20 year old man is brought to the ER by his girlfriend after she found him unconscious in the bathroom of his apartment. He smokes 20 cigarettes a day and has a history of methamphetamine, cocaine, and heroin use. Temperature is 36.4° HR is 71 beats/min, respirations are 9 breaths/min, BP is 94/56 mm Hg, and oxygen saturation is 92%. Physical examination shows pinpoint pupils. Which of the following is the mechanism of action of the antidote that will be given to this patient?A. Production of glutathione reserves.B. Competitive binding with sulfhydryl groups on ionsC. Binding ot benzodiazepine receptorsD. Antagonism of opioid receptorsE. Interaction with alcohol dehydrogenase.

A

D. Antagonism of opioid receptorsMorphine(full agonist) OD = Antidote: Naloxone (Opioid receptor antagonist)

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5
Q

A 36 y/o man complains to his physician of an inability to concentrate on his work, diminished interest in social and recreational activities, difficulty sleeping, and a general feeling of hopelessness. After a thorough evaluation, his physician prescribes psychotherapy and medication. Four weeks later, the man returns to his physician indicating that his symptoms have improved but that he is experienced delayed ejaculation and anorgasmmia. The drug prescribed for this patient most likely acts by which mechanism? A. Blockade of presynaptic receptorsB. Inhibition of neuronal reuptake of DopamineC. Inhibition of neuronal repute of norepinephrineD. Inhibition of neuronal repute of serotoninE. Inhibition of monoamine oxidase

A

D. Inhibition of neuronal repute of serotoninAE of SSRIs which include Fluoxetine, Paroxetine, Fluvoxamine, Citalopram and Sertraline areAnxietyAgitation (may need sedative)BruxismSexual dysfunction(anorgasmia)Seizures(in OD).Weight loss but regained after 12 months treatment

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6
Q

34 A 29 y/o patient is taking antidepressant. He complains of feeling jittery and agitated at times and if he takes his medication in the afternoon he finds it difficult to get to sleep at night. He seems to have lost weight during the 6 months that he has been taking the drug. He has been warned not to take other drugs without consultation because severe reactions occurreed with opioid analgesics. The patient is probably takingA. AlprazolamB. ParoxetineC. TrazodoneD. BupropionE. CHhlorpromazine

A

B. Paroxetine

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7
Q

A 51 y/o woman with symptoms of major depression also has narrow-angle glaucoma. Which of the following should be avoided this patient?A. SertralineB. MirtazepineC. AmitriptylineD. FluvoxamineE. Bupropion

A

C. Amitriptyline

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8
Q

A 25 y/o woman had a long history of depressive symptoms accompanied by body aches. Physical and laboratory tests were unremarkable. Which of the following drugs might be useful in this patient?A. DuloxetineB. SertralineC. PhenelzineD. MirtazapineE. Fluoxetine

A

A. Duloxetine

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9
Q

A patient has frequent facial tics and spontaneous outburst of foul language (coprolalia). Which of the following drugs would most likely be and probably most efficacious and safe initial treatment for this, assuming no specific contraindications to using it?A. ClozapineB. LevodopaC. PhenpbarbitalD. MethylphenidateE. Haloperidol

A

E. Haloperidol

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10
Q

A 36 y/o man presents with symptoms of compulsive behavior. He must repeatedly align and realign the items on his desk thoughout the day. If anything is out of order he feels that “work will not be accomplished effectively or efficiently.” He realized that his behavior is interfering with his ability to accomplish his daily tasks, but cannot seem to stop himself, Which of the following drugs would be most helpful to this patient?A. ClozapineB. FluvoxamineC. PhenobarbitalD. MethylphenidateE. Haloperidol

A

B. Fluvoxamine

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11
Q

A 51 y/o woman requires drug therapy for major depression. Her records indicate that she is currently being treated with Guanethidine for hypertension. Which agent would be appropriate for the patient’s mood disorder but would most likely interfere with or antagonize her antihypterensive therapy?A. CarbamazepineB. HaloperidolC. MidazolamD. NortriptylineE. Sertraline

A

D. Nortriptyline

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12
Q

Anesthesia protocols for day surgery may include sevoflurane because recovery from this agent is more rapid than that for older inhaled anesthetics. Rapid recovery from anesthesia with sevoflurane is associated with itsA. Redistribution from brain to skeletal muscleB. Low MAC valueC. Rapid metabolism of liver enzymesD. Low blood-gas partition coefficientE. None of the above

A

D. Low blood-gas partition coefficient

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13
Q

A patient develops profound fever, skeletal muscle rigidity, and autonomic and systemic electrolyte imbalances as part of a severe adverse response to psychoactive drug. The working diagnosis is neuroleptic malignant syndrome. In addition to adminstering dantrolene in an attempt to restore some resemblance of normal skeletal muscle function, which of the following other drugs is most likely to be given to help provide additional symptom relief?A. NaloxoneB. BromocriptineC. FlumazenilD. DiazepamE. BenztropineF. Propranolol?

A

B. Bromocriptine

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14
Q

A 55 y/o teacher began to experience changes in mood. He was losing interest in his work and lacked the desire to play his daily tennis match. He began to have difficult thinking and concentrating and lacked decisiveness. He was preoccupied with feelings of guilt, worthlessness, and hopelessness. In addition to the psychiatric symptoms, the patient complained of muscle aches throughout his body. Physical and laboratory tests were unremarkable. After six weeks of therapy with fluoxetine, the patients symptoms resolve. However, that patient complains of sexual dysfunction. Which of the following drugs might be useful in this patient?A. LithiumB. SertralineC. ParoxeteneD. FluvoxamineE. Mirtazapine

A

E. Mirtazapine

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15
Q

A 55 y/o hospitalized man who has not responded to first-line antidepressant medications is being treated with a drug considered to be a second line treatment for depression. The hospital staff has been advised not to give him and foods containing tyramine. Tyramine is an indirect acting amine found in dietary sources such as cheese, preserved sausages, and wine. The amine stimulates the sympathetic response by releasing norepinephrine from the synaptic vesicles. Which of the following antidepressant drugs was most likely prescribed to treat this patient?A. EscitalopramB. BupropionC. ImipramineD. BuspironeE. Tranylcypromine

A

E. Tranylcypromine

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16
Q

About one year ago you diagnosed schizophrenia signs and symptoms in a 23 y/o otherwise healthy man. As a result of intensive psychotherapy, careful titration of chlorpromazine dosages, and remarkably good compliance on the patient’s part, he is well enough to return to work. Several months later at a scheduled visit, you observe numerous S/S of drug induced parkinsonism, and the patient reports rather distressing symptoms of akathisias. However, he states no recurrences of schizophrenia manifestations. Which of the following approves is most likely to alleviate the motor an subjective parkinsonian responses, and poses the lowest risk of causing schizophrenia signs and symptoms to reappear?A. Add a centrally acting cholinesterase inhibitor (e.g., donepezil or tacrineB. Add levodopa or levodopa plus carbidopaC. Add benztropineD. Switch from chlorpromazine to haloperidolE. Add a catechol-O-methyltransferase inhibitor (e.g., tolcapone)

A

C. Add benztropine

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17
Q

A patient suffering from bipolar affective disorder becomes pregnant. A drug that has been shown to have some clinical value in alleviated BAD symptoms and that is unlikely to cause problems regarding fetal development is?A. CarbamezepineB. ClonazepamC. Valproic acidD. PhenytoinE. Methylphenidate

A

B. Clonazepam

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18
Q

A 33 y/o female patient treated with haloperidol for a hx of schizophrenia is seen in the ED because of complaints of fever, stiffness, and tremor. Her temperature is 104°F, and her serum creatine kinase (CK) level is elevated. What has occurred?A. OverdoseB. ParkinsonismC. AllergyD. Tardive DyskinesiaE. Neuroleptic malignant syndrome (NMS)

A

E. Neuroleptic malignant syndrome (NMS)

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19
Q

Which of the following drugs is a full agonist at opioid receptors; has excellent oral bioavailability, analgesic activity equivalent to that of morphine, and a longer duration of action; and milder withdrawal signs on abrupt D/C than morphine?A. NalbuphineB. OxycodoneC. FentanylD. MethadoneE. Propoxyphene

A

D. Methadone

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20
Q

A 45 y/o male with alcoholic cirrhosis is seen in the ED because of a laceration of the scalp. Of the following local anesthetics, which would be potentially toxic?A. Chlor ProcaineB. BenzocaineC. TetracaineD. LidocaineE. Procaine

A

D. Lidocaine

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21
Q

A patient is transported to your emergencey department because of a seizure. A review of his history reveals that he has been treated by different physicians for different medical conditions, and there has ben no dialog between the two doctors in terms of what they’ve prescribed. One physicians has prescribed a drug for short term management of depression. Another has prescribed the very same drug to help the patient quit smoking cigarettes. Which of the following was most likely prescribed by both doctors, and was the most likely cause of the seizures?A.LithiumB. FluoxetineC. ChlordiazepoxideD. ImipramineE. Bupropion

A

E. Bupropion

22
Q

A patient has been diagnosed has having caridiotoxicity. Which of the following drugs used in the management of psychosis is most likely to cause the cardiotoxicity?A. ThioridazineB. DiazepamC. FluoxetineD. EthosuximideE. All of the above

A

A. Thioridazine

23
Q

A patient is on long-term methadone therapy as part of a holistic plan to curb the opioid addiction and abuse. Which of the following best describes a characteristic of this drug?A. Causes pentazocine-like activation of receptors and blockade of receptorsB. Remarkably devoid of such typical opioid analgesic side effects as constipation and respiratory depressionC. Has greater oral bioavailability than morphine, especially when oral administration is startedD. When abruptly stopped after long-term administration, causes a withdrawal syndrome that is more intense, but briefer, than that association with morphine or heroin withdrawal

A

C. Has greater oral bioavailability than morphine, especially when oral administration is started

24
Q

26 y/o woman with depression has been on antidepressant therapy for several months. Today she complains of missing her period and having galactorrhea, and your careful assessment suggests she has developed some dyskinesias not unlike those you would typically associate with a phenothiazine or butyrophenone (haloperidol) antipsychotic drug. Pregnancy tests are negative. Which of the following is most likely to have caused these findings?A. AmoxapineB. TranylcypromineC. CitalopramD. SertralineE. Fluoxetine

A

A. Amoxapine

25
Q

A 31 y/o man with schizophrenia is evaluated because of signs of tradeoff dyskinesia. He has been treated with several different medications to control his schizophrenia during the past several years. His physician stops treatment with his current medication and prescribes Clozapine 25 mg. He is currently taking no other medications. This patient is most likely to require special monitoring and surveillance due to the potential of Clozapine to cause which of the following adverse effects?A. AgranulocytosisB. SeizuresC. Orthostatic HTND. QT prolongationE. Diabetes

A

A. Agranulocytosis

26
Q

We have a patient with Parkinson’s disease and administer a drug that acts in the CNS as an agonist for dopamine receptors. It has no direct effects on dopamine synthesis, neuronal repute, or metabolic inactivation. Which of the following drugs best fits this description?A. BenztropineB. AmantadineC. TolcaponeD. RoperinoleE. Selegiline

A

D. Roperinole

27
Q

A 5 y/o boy consumed a liquid from a container in the family garage. He presents with central nervous system CNS depression, obtunded reflexes, and ventilatory depression. A blood sample indicates profound metabolic acidosis. A check of the urine reveals crystals that are presumed to be oxalate. Which of the following is the most likely cause of the poisoning?A. Paint thinner such as acetoneB. An insecticide (organophosphate cholinesterase inhibitor)C. Ethylene glycolD. GasolineE. Halogenated hydrocarbon from a can of spray paint

A

?

28
Q

Trihexyphenidyl is prescribed as an adjunct to other drugs being used to manage a patient with Parkinson’s Disease. Which of th following si the most likely purpose or action of this drug as part of the overall drug treatment plan?A. To counteract sedation that is likely to be caused by the other medicationsB. TO manage cutaneous allergic responses that are so common with “typical” anti-Parkinson’s drugs.C. To help correct further the dopamine -Ach imbalance that accounts for Parkinsonian signs and symptoms.D. To reverse tardive dyskinesias if the Parkinsonism was induced by an antipsychotic drugE. To prevent the development of mani-hypomanic responses to other anti-Parkison drugs

A

C. To help correct further the dopamine -Ach imbalance that accounts for Parkinsonian signs and symptoms.

29
Q

A 42 y/o woman develops akanthisias, Parkinsonian-like symptoms, galactorrhea, and amenorrhea, during drug therapy. Which of the following drug-receptor-based mechanisms, occurring in the central nervous system, most likely caused these responses?A. Blockade of alpha - adrenergic receptorsB. Blockade of dopamine receptorsC. Blockade of muscarinic receptorsD. Stimulation of nicotinic receptorsE. Supersensitivity of dopamine receptors

A

B. Blockade of dopamine receptors

30
Q

A patient has a long history excessive alcohol consumption. He was arrested for drunk driving and was referred to a physician for therapy. The MD prescribed a drug to stifle further alcohol ingestion, to be used along with other interventions. The patient was instructed not to consume any alcohol, not to use alcohol-containing mouthwashes, or even apply alcohol based toiletries, because alcohol may cause a distrubgin, if not dangerous interaction with his medication. The patient ignored the advice and decided to have a cocktail. Within minutes he develops flushing, a throbbing headache, nausea, and vomiting. Which of the following medications was he most likely taking?A. DisulfiramB. NaltrexoneC. DiazepamD. PhenobarbitalE. Tranylcypromine

A

A. Disulfiram

31
Q

A 63 y/o man is evaluated during a follow up visit. He was hospitalized 7 days ago with a non ST elevation myocardial infarction and underwent intracoronary stent placement. he is now pain free, but whats help with smoking cessation; he has smoked one pack of cigarettes daily for 40 years. His past medical history is notable for coronary artery disease, hyperlipidemia, hypertension, and a seizure disorder. His prescription medications included atenolol, clopidogrel, hydrochlorothiazide, phenytoin, and simvastatin. On exam, he is afebrile with a blood pressure of 124/68 mm Hg and a pulse rate of 62/min. His jugular venous pressure is not elevated, his heart sounds are normal, and his lungs are clear. In addition to counseling for smoking cessation techniques, which of the following is the most appropriate drug treatment in this patient?A. VareniclineB. All of the aboveC. Nicotine replacementD. FluoxetineE. Bupropion

A

A. Varenicline

32
Q

A 24 year woman comes to clinic for routine health examination. She reports that she has been feeling well except for a nagging cough she has had for the last 2 weeks following an URT infection. She says she is interested in a medication to help her quit smoking. ON examination she is thin with a BMI of 17.5 kg/m2. The remainder of her examination is unremarkable. What is the mechanism of action for the best medication for smoking cessation in this patient?A. inhibits serotonin reuptakeB. Inhibits acetaldehyde dehydrogenaseC. Inhibits dopamine reuptakeD. Antagonist of Nicotinic receptorE. Partial agonist of nicotinic receptor

A

E. Partial agonist of nicotinic receptor

33
Q

A 26 y/o man with a known history of substance abuse is exhibiting violent and aggressive behavior and is brought to the emergency department. Examination of the patient shows the presence of extreme agitation, hyperthermia, hypertension, tachycardia, tachypnea, horizontal and vertical nystagmus, mydriasis, and numbness of the distal extremities The patient is most likely intoxicated with A. DiazepamB. EthanolC. PhencyclidineD. HeroinE. Lysergic acid diethlamid (LSD)

A

C. Phencyclidine

34
Q

Chlorpromazine (anti-psychotic drug (anti dopaminergic)) has been prescribed for a patient with schizophrenia, and the patient has been taking the drug, at usually effective doses, for about 6 months. Today he comes to the hospital with other medical conditions that require surgery and the administration of other drugs, and we decide it is unwise to stop the chlorpromazine and run the risk of psychotic behavior while we perform other interventions. Which of the following other signs/symptoms that the patient may also have or acquire as the result of surgery and drug therapy is most likely to be affected beneficially by the continued use of chlorpromazine?A. Epilepsy and the risk of seizuresB. HypotensionC. Zerostomia (dry mouth) caused by antimuscarinic drugs used to prevent intraoperative bradycardiaD. Nausea and vomitingE. Urinary retention caused by abdominal surgery

A

D. Nausea and vomiting

35
Q

A patient of age 65 years having insomnia is using various drugs and the patient is abusing these drugs. Now he is asking the physician to prescribe the drug without abusing potential. Physician suggested psychotherapy and long with psychotherapy physician prescribed a drug. The drug prescribed was most likely to have beenA. DiazepamB. ZolpidemC. AlprazolamD. MidazolamE. Phenobarbital

A

?

36
Q

A 34 y/o man with mild anxiety and depression symptoms has heard about buspirone on television and asks whether it might be suitable for him. According to the latest diagnostic criteria, the drug would be appropriate, particularly for short term symptom control. Which of the following best describes an important property of this drug?A. Has a significant potential for abuseB. Requires almost daily dosage titrations in order to optimize the responseC. Is likely to potentiate the CNS depressant effects of alcohol, benzodiazepines, and sedative antihistamines, so such interactants must be avoided at all costD. Seldom causes drowsinessE. Associated with a withdrawal syndrome that, if unsupervised, is frequently lethal

A

D. Seldom causes d

37
Q

A 14 y/o is brought to the ED by her mother, who has observed that her daughter has abruptly experienced frequent impairments of consciousness associated with episodes of staring into space lasting approximately 30 second. With which of the following drugs should we start treatment?A. AlprazolamB. EthosuximideC. MidazolamD. DiazepamE. Phenytoin

A

?

38
Q

A nine year old boy is sent for neurologic evaluation because of episodes of “confusion.” Over the past year, the child has experienced episodes during which he develops a blank look on his face and fails to respond to questions. However, it appears to take several minutes before the boy recovers from the episodes. Which one of the following therapies would be most appropriate in this patient?A. EthosuximideB. CarbamazepineC. DiazepamD. BuspironeE. Thiopental

A

A. Ethosuximide

39
Q

A young boy who has been treated for epilepsy for a year is referred to a periodontist for evaluation and probably treatment of massive overgrowth of his gingival tissues. Some teeth are almost completely covered with hyper plastic tissue. Which of the following drugs was the most likely cause of the oral pathology?A. CarbamazepineB. LorazepamC. PehnobarbitalD. PhenytoinE. Valproic acid

A

D. Phenytoin

40
Q

A 74 y/o man with Parkinson’s disease has been managed with levodopa/carbidopa for 3 years. An additional drug is now added to the therapeutic regimen to further improve control of symptoms. The drug added that prevents the oxidative deamination of dopamine. The drug isA. EntacaponeB. BenztropineC. RipirenoleD. TranylcypromineE. Selegeline

A

E. Selegeline

41
Q

A 37 y/o bipolar, hypertensive woman takes multiple medications. Concurrent use of which of the following drugs could decrease the effectiveness of her estrogen-progestin combination oral contraceptive?A. CarbamazepineB. EnalaprilC. LithiumD. Valproic acidE. Metoprolol

A

?

42
Q

In Parkinsonian patients who have prostatic hypertrophy or obstructive gastro intestinal disease, great caution must be exercised in the use of which of the following drugs?A. CarbidopaB. BenztropineC. SlegilineD. EntacaponeE. Levodopa

A

B. Benztropine

43
Q

A patient who has been treated with levodopa is switched to a regimen with a proprietary product that contains both levodopa and carbidopa. Which of the following is the main action of carbidopa that provides the rationale for using it in this combined approach?A. Blocks Ach release in the CNS, thereby facilitating levodopa’s ability to restore a dopamine Ach balanceB. Helps activate dietary vitamin B6, a deficiency of which of occurs during levodopa therapyC. Reduces levodop-induced hypotension by blocking vascular dopamine receptorsD. Increases the permeability of the blood-brain barrier to levodopa, giving levodopa better access to the CNSE. Inhibits metabolic conversion of levodopa to dopamine outside the CNS

A

?

44
Q

A young woman is taken to the emergency department by some of her friends. It seems they were out on “bar night” and someone slipped something into her alcoholic beverage, the first and only one she consumed that night. She is now extraordinarily drowsy and has little recall of what happened between the time she sipped her drink and now. Someone overheard another bar patron talking about “roofs”. Being knowledgable about your pharmacology you suspect her drink was spiked with rohypnol. Assuming your guess is correct, which of the following drugs is most likely to reverse the flunitrazepam’s effects?A. TriazolamB. FlumazenilC. KetamineD. NaltrexoneE. Diazepam

A

B. Flumazenil

45
Q

A 72 y/o woman with a long history of anxiety that has been treated with diazepam decides to triple her daily dose because of increasing fearfulness about “environmental noises.” Two days after her attempt at self prescribing, she is found extremely lethargic and non responsive with markedly obtunded reflexes and reaction to painful stimuli. Respirations are 8/min and shallow. Which of the following drugs should we give specifically to reverse these signs and symptoms?A. NaltrexoneB. DextroamphetamineC. PralidoximeD. PhysostigmineE. Flumazenil

A

?

46
Q

A 58 year old man presenting with difficulty in initiating movement and a resting tremor. On physical examination his face appears expressionless and he has a slow shuffling gait. He is started on medication. After using the drug, the patient came with complaints of edema and skin mottling. What drug is the patient might be using?A. EntacaponeB. LevodopaC. TolcaponeD. CarbidopaE. Amantadine

A

?

47
Q

We have a patient who will start taking one of the drugs listed. As we hand them the prescription we advise them not to take supplemental vitamin B6 (pyridoxine), whether alone or as part of a multivitamin supplement, because the vitamin is likely to counteract a desired effect of the prescribed drug. To which of the following drugs does this advice apply?A. Haloperiodl for Tourette’s syndromeB. Captopril for heart failure or hypertensionC. Levodopa/CarbidopaD. Niacin for hypertriglyceridemiaE. Phenytoin for epilepsy

A

C. Levodopa/Carbidopa

48
Q

A 39 year old man who has partial seizures with secondary generalized tonic-clonic seizures has been treated with phenytoin for 4 years. The therapy has been only minimally successful, and the physician plans to add another drug to the treatment regimen. Which of the following game-aminobutyric acid analogues would be most appropriate to add as adjunct therapy for the prevention of seizures in this patient?A. GabapentinB. DiazepamC. EthosuximideD. LamotrigineE. Topiramate

A

A. Gabapentin

49
Q

A 52 y/o woman with a history of alcoholism is brought to the emergency department by her brother. The brother reports that the woman had been a heavy drinker for years, but that she decided to “go on the wagon” 3 days ago. When the brother saw her this morning, she was acting confused and then had a “rum fit”. Now she is suffering from hallucinations, agitation, tachycardia, and fever. Immediate treatment of the patient would include administration ofA. DisulfiramB. BuspironeC. NaltrexoneD. DiasepamE. Flumazenil

A

D. Diasepam

50
Q

A woman has been taking a prescribed drug throughout her pregnancy. Starting about a month before her expected delivery date we start administering oral vitamin K supplements, and when the baby is born he/she is given an injection of vitamin K. The goal is to reduce the risks of excessive or abnormal bleeding, caused by drug-induced impairments of hepatic vitamin K- depended clotting factors, in the newborn. For which of the following drugs are these precautions most likely to be needed?A. NaloxoneB. DiazepamC. MethadoneD. PhenobarbitalE. Bupropion

A

?