Pharmacology Special Cases Flashcards
1
Q
Theoretical role of using anabolic followed by anti resorptive
A
Pros: build up more bone, earlier fracture prevention
Cons: side effects, cost
2
Q
Role of androgens in male bone homeostasis
A
Account for larger peak bone mass in men than in women
Responsible for periosteal bone formation
Deficiency results in reduced bone width and formation
3
Q
Pagets disease pathology
A
Osteoclasts increased in number and size Overactive osteoblasts Accelerated bone turnover Matrix is disorganized Bone size increased but more brittle
4
Q
Clinical manifestations of paget’s
A
Bone pain (unrelenting, worse at night, osteoarthritis) Neurologic complication/compression Bone deformity Fracture Osteosarcoma
5
Q
2 situations where you should consider a drug holiday
A
Patients discontinuing GCs
Those who should not have been started on treatment in the first place (low fracture risk)
6
Q
No drug holiday for what 4 meds
A
HRT
SERMs
Teriparatide
Denosumab
