Pharmacology - Schizophrenia - Sleep disorder

Question 1

What are the agents used in Schizophrenia?

Answer 1

Benzodiazepines: lorazepam, diazepam
Antipsychotics:
1. FGA - haloperidol, chlorpromazine
2. SGA - olanzapine, quetiapine, risperidone, clozapine, aripiprazole, brexpiprazole, lurasidone, cariprazine

Question 2

What are the agents used for MDD?

Answer 2

1st line
SSRI: Fluvoxamine, fluoxetine, paroxetine, setraline, escitalopram, citalopram
SNRI: Venlafaxine, desvenlafaxine, duloxetine
NaSSA: mirtazapine
NDRI: bupropion

SMS: Vortioxetine
TCA: amitriptyline, nortriptyline, clomipramine
MAOIs/RIMA: Moclobemide
Serotonin antagonist and reuptake inhib:Trazadone
NMDA rece antagonist: agomelatine

Question 3

What are the agents used for bipolar disorder?

Answer 3

Benzodiazepines: lorazepam, clonazepam, midazolam

Question 4

What are the agents used for bipolar mania?

Answer 4

1st line: Li

2nd line: Antipsychotics SGA>FGA

3rd line: Valproate
If insuff: Li + valproate/other mood stabilisers

Question 5

What are the agents used for bipolar depression?

Answer 5

DO NOT use antidepressants

Li
Antipsychotics SGA: quetiapine, olanz+fluoextine > lurasidone, cariprazine
Lamotrigine

Question 6

What are the agents used in anxiety?

Answer 6

Benzodiazepines: lorazepam, diazepam, alprazolam

GAD: SSRI- escitalopram, paroxetine, pregabalin, TCAs

Panic disorder: SSRI- fluoxetine, paroxetine, setraline>TCAs>MAOI, valproate

SAD: SSRI-fluvoxamine, paroxetine, setraline>MAOI/RIMA

OCD: SSRI-fluvoxamine, fluoxetine, paroxetine, setraline>Clomipramine>Venlafaxine

PTSD: SSRI- paroxetine, setraline>Clomipramine

Question 7

What are the agents used in insomnia?

Answer 7

Benzodiazepines

Z-hypnotics: zopiclone, zolpidem
Antihistamines: hydroxyzine, promethazine
Melatonin
Lemborexant