Pharmacology- pharmacokinetics

Question 1

What is context sensitive half time (CSHT)

Answer 1

Defined as the time required to achieve a 50% decrease in plasma concentration after stopping a continuous, steady-state infusion, the CSHT is a means of normalizing the pharmacokinetic behavior of drugs so that rational comparisons can be made regarding the predicted offset of drug effect. The CSHT is thus focused on infusion back-end kinetics.