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Pharmacology midterm 2 > Pharmacology of the central dopaminergic systems > Flashcards

Pharmacology of the central dopaminergic systems Flashcards

1
Q

Major Dopaminergic pathways in brain

A

mesocortical
mesolimbic
nigrostriatal
tuberoinfundibular

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2
Q

Mesolimbic pathway

A

associated with: Reward and Learned behaviors

dysfunction: Scizophrenia, Psychosis, Addiction

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3
Q

Mesocortical pathway

A

associated with: Motivation, Emotion and Impulse control

dysfunction: Scizophrenia, Psychosis, ADHD

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4
Q

Nigrostriatal pathway

A

associated with: Movement regulation

dysfunction: Parkinson, Movement side effects

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5
Q

Tuberoinfundibular

A

associated with: Regulation of prolactin secretion

dysfunction: Hyperprolactinemia

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6
Q

D1 receptors

A
  • increase cAMP
  • SNpr
  • frontal cortex
  • Nucleus Acc
  • Hypothalamus
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7
Q

D4 receptors

A
  • Increase cAMP
  • hypothalamus
  • striatum
  • NAc
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8
Q

D2 receptors

A
  • decerase cAMP, increase K+ currents, decrease voltage-gated Ca2+ currents
  • striatum
  • SNpc
  • pituitary
  • PFC
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9
Q

D3 receptors

A
  • decerase cAMP, increase K+ currents, decrease voltage-gated Ca2+ currents
  • nucleus accumbens
  • SNpc
  • VTA
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Pharmacology midterm 2 (5 decks)

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