Pharmacology of pain management Flashcards
1
Q
Types of pain?
A
visceral nociceptive
somatic nociceptive
neuropathic
somatic
central sensitisation
2
Q
Central sensitisation
A
3
Q
Type of nociceptors?
A
Heat- TRPV-1 (peripheral and central) - brain and dorsal horn.
TREK1
mechanical pressure- MDEL7
4
Q
Prostaglandin receptors
A
prostanoic receptors - G coupled receptors (Gs)
5
Q
1st order neuorons
A
dorsal root ganglia
then goes to the dorsal horn
6
Q
Nitric oxide
A
inhibits the abilty of opioids to hyperpolarize the presynaptic terminal
7
Q
What is substance P?
A
NK1 receptor.
neurokinenin
increases neuronal excitability.
8
Q
Management ladder
A
Mild pain (1-3/ 10) acetaminophen +- NSAID
Moderate pain (4-6/ 10): Acetaminophen + NSAID +- Weak Opioid (e.g., Tramadol)
Severe pain (7-10/ 10) : Acetaminophen
9
Q
Multimodal therapy
A
10
Q
OPieo
A
11
Q
A
12
Q
A
