Pharmacology of ectoparasites Flashcards
four pathogens transmitted by fleas
- Dipylidium caninum
- acanthocheilonema reconditum
- bartonella henselae
- Rickettsia felis
what do adult fleas need to do before reproduction?
blood feed required before reproduction
- how fast do fleas feed on animal?
- how fast do they lay eggs?
- within 1 hour on animal, >85% of fleas have fed
- egg production starts 24-48 hours after first blood meal > up to 50 eggs per day/ flea
where does the adult flea live? how long does it spend on the animal?
adult flea is generally permanently on animal
seasonality of fleas in ontario
- May to november in Ontario
- Winter is too dry for them, generally
where are fleas most prevalent geographically?
mostly southeastern USA, another pocket on south-west coast of california
flea life cycle stages present in infested environment
- 5% adults
- 10% pupae
- 35% larvae
- 50% eggs
flea only products - adulticide options
- imidacloprid
- nitenpyram
Imidacloprid
- what is this drug for?
- drug class?
- action?
- licensed use?
Drug class: neonicotinoid
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Action: acts at nicotinic cholinergic synapse
> interacts with post-synaptic nicotinic receptor
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Licensed as:
- monthly spot-on for control of fleas on dogs and cats
- flea adulticide
Imidacloprid pharmacokinetics
- how it works, how fast, how long it lasts
surface translocation > whole body coverage
- distributed over entire body in 12 hours (cats) or 24 hours (dogs)
- not absorbed
- stops fleas biting 3-5 minutes after contact with drug
- kills on contact, ie. biting not required
- >99% fleas killed within 24 hours
- photostable > residual activity for 4+ weeks
imidacloprid safety / toxicity
- no reports of imidacloprid causing toxicity in dogs or cats following dermal exposure
- alcohol carrier may lead to follicular shedding (on neck)
- do not use in birds > highly toxic
imidacloprid is contained in what vet products?
- K9 Advantix II
- Advantage Multi
<><> - Advantage II + K9 Advantix II approved as pest-control products
- Advantage Multi approved as a drug
can we use imidacloprid in suckling animals?
if puppies/kittens suckling, just treat mother (minimum age for Advantage II = 7/8 weeks)
what non-flea parasites is imidacloprid labeled for?
biting/sucking lice on dogs
nitenpyram
- what is its class?
- action
- licensed use
Drug class: neonicotinoid
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Action: Action: acts at nicotinic cholinergic synapse
> interacts with post-synaptic nicotinic receptor
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Licensed as: oral adulticide for fleas on dogs & cats