Pharmacology of androgens and anti-androgens

Question 1

Which molecule is the man starting reactant in the synthesis of testosterone?

Answer 1

Cholesterol

Question 2

Which main pathway is targeted in the treatment of prostate cancer?

Answer 2

Inhibition of DHT to reduce amplification of testosterone actions

Question 3

Which drug inhibits gonadotrophin release in prostate cancer?

Answer 3

Diethylstilboestrol

Question 4

What is a common drug usually used to treat hyper-sexuality by inhibiting androgen receptors?

Answer 4

Cyroterone acetate, inhibits androgen receptor

Question 5

Enlargement of benign prostate cancer causes urinary obstruction. Give an example of A-1 adrenoceptor blocker and its resulting effect

Answer 5

Alfuzosin, smooth muscle relaxant

Question 6

Best method to treat hormone dependent cancer?

Answer 6

Inhibit androgen receptor activity and suppress leydig function

Question 7

Gynaecomastia, i.e. development of breast in boys, can be caused by?

Answer 7

Excessive oestrogen production by sertoli cell tumour

Question 8

How does phenotolamine aid treatment of erectile dysfunction?

Answer 8

Injection into crus of penis causing vessel expansion