Pharmacology of Alimentary

Question 1

What are the maind drug classes used in treatment of GI disease?

Answer 1

1) Acid suppressants - PPI’s, Antacids, H2-receptor antagonists
2) Motility drugs - anti-motility, anti-spasmodics
3) Laxatives

Question 2

What are the classes of drugs used for inflammatory bowel disorders?

Answer 2

1) Aminosalicylates
2) Corticosteroids
3) Immunosuppressants
4) Biologics

Question 3

How do H2 receptor antagonists work?

Answer 3

Block the histamine receptor therefore reducing acid secretion

Question 4

How do GI motility drugs work?

Answer 4

They block opiate receptors in GI tract to decrease ACh release and therefore decrease smooth muscle contraction and increase anal sphincter tone

Question 5

How do anti-spasmodic drugs work?

Answer 5

1) Anti-cholinergic effects - smooth muscle relaxation

Question 6

How do laxatives work?

Answer 6

1) Increasing bulk
2) Drawing fluid into gut

Question 7

What is a common aminosalicylate drug?

Answer 7

Mesalazine

Question 8

What is a common immunosuppressant drug given for inflammatory bowel disorders?

Answer 8

Azathioprine - inhibits purine synthesis

Question 9

What is the common biologic drug used in IBD?

Answer 9

Infliximab