Pharmacology MCQs Flashcards
Volume of distribution equals
Select one:
a. dose given/plasma concentration
b. total amount of drug in the body/plasma concentration
c. urine drug concentration/plasma concentration
d. Dose given/urine concentration
Regarding receptor regulation
Select one:
a. receptor down regulation occurs over hours – days
b. receptor responses to drugs often desensitise with time – this desensitisation is usually irreversible
c. the mechanism of agonist induced desensitisation of the nicotinic acetyl choline receptor has been worked out in detail
d. all internalised receptors are degraded by lysosomes
Which of the following is a phase one (functionalisation) reaction
Select one:
a. reduction
b. acetylation
c. glucuronidation
d. methylation
What is the half life of a drug with a volume of distribution of 700L/70kg and clearance of 49L/hour/70kg
Select one:
a. 7 hours
b. 10 hours
c. 12.5 hours
d. 15 hours
You are given a vial with 15ml of 0.5% prilocaine to do an arm block. How many mg of prilocaine are you injecting
Select one:
a. 15mg
b. 30mg
c. 50mg
d. 75mg
Regarding first-pass metabolism
Select one:
a. sublingual drug administration completely bypasses the liver
b. approximately 50% of a rectally administered dose bypasses the liver
c. first-pass elimination does not occur in drugs administered by inhalation
d. the inferior haemorrhoidal vein drains into the portal system
EC50 is
Select one:
a. measured with a radioactive receptor
b. drug concentration with 50% receptors bound
c. representation of the receptors affinity for drug binding
d. drug concentration with 50% of maximal drug effect
Which of the following is a direct serotonin agonist
Select one:
a. fluoxetine
b. moclobemide
c. ondansetron
d. sumatriptan
The duration of action of an irreversible antagonist is dependent on
Select one:
a. its rate of elimination
b. the rate of turnover of receptor molecules
c. the potency of the agonist
d. the maximal efficacy of the agonist
b. the rate of turnover of receptor molecules
