Pharmacology last lecture

Question 1

What affects variable drug response in humans?

Answer 1

1. age
2. disease
3. sex
4. other drugs + xenobiotics
5. genetics

due to differences in
- pharmacodynamics
- pharmacokinetics

Question 2

xenobiotic

Answer 2

a chemical substance found within an organism that is not naturally produced or expected to be present within the organism.

• It can also cover substances that are present in much higher concentrations than are usual

Question 3

autosome

Answer 3

all chromosomes that are not sex chromosomes

Question 4

allosome

Answer 4

sex chromosomes

Question 5

Hardy-Weinburg Law

Answer 5

for two distinct alleles (A and a) (WT and mut), the possible combinations are:
AA Aa aa

(AA + aa = homozygotes)
(Aa = heterozygote)

the frequency of of genotype combination is:

1= A^2 + 2Aa + a^2

Question 6

autosomal dominant

Answer 6

mutant allele dominates

Question 7

autosomal recessive

Answer 7

mutant phenotype is only present if both alleles are present (e.g. aa)

Question 8

x-linked recessive

Answer 8

phenotype occurs more frequently in males (1xchr)

Question 9

autosomal co-dominant

Answer 9

phenotype is the average of each allele