Pharmacology/kinetics of IV Drugs

Question 1

What is the best anti-emetic for a person with parkinson’s?

Answer 1

Zofran. (will not produce extrapyramidal symptoms)

Question 2

What drug is converted from water-soluble to lipid-soluble when it enters the bloodstream?

Answer 2

Midazolam

Question 3

When at 1.2 MAC of sevofluorane (iso too) what is the maximum dose of epinephrine that a person will absolutely not have ventricular arrhythmias?

Answer 3

5ug/kg

Question 4

what will beta blockers not cause when used for Hypertension?

Answer 4

orthostatic hypotension

Question 5

Which anticholinesterase can cross the BBB?

Answer 5

Physostigmine

Question 6

Which drug will reverse Opioid constipation without reversing it’s analgesia?

Answer 6

Methylnaltrexone because it doesnt cross BBB.

Also does not get absorbed by gut so has to be IV

Question 7

What must you be careful with in someone on HIV drugs?

Answer 7

CYP3A4 inhibition (ie longer duration of benzos and opioids)

Question 8

What is the concern with someone on Echothiopate for glaucoma?

Answer 8

It is an organophosphate that inhibits acetylcholinesterase AND pseudocholinesterase.
Succinylcholine and ester-LA will last longer.