Pharmacology Extra

Question 1

In whom should you prescribe cyclizine with caution?

Answer 1

severe heart failure - may cause fall in CO

Question 2

Is chronic or acute alcohol intake associated with a reduced risk of hepatotoxicity?

Answer 2

Acute alcohol intake is protective following a paracetamol overdose

Question 3

What pattern or acid-base abnormalities present following an aspirin overdose:

Answer 3

initially: respiratory alkalosis
eventually: metabolic acidosis

Question 4

What mechanism of action of aspirin makes it an anti platelet?

Answer 4

Thromboxane A2

Question 5

What do antipsychotics increase the risk of in the elderly?

Answer 5

VTE - stroke

Question 6

What are the antimuscarinic side effects of e.g. antipsychotics?

Answer 6

• dry mouth
• constipation
• blurred vision
• urinary retention

Question 7

How should you manage someone on metformin who is having a CT scan?

Answer 7

Discontinue metformin for 48 hours after the scan due to risk of renal impairment

Question 8

What are divergent pupils a sign of?

Answer 8

TCA overdose

Question 9

What opioid can also cause serotonin syndrome?

Answer 9

Tramadol - weak SNRI

Question 10

What is imipramine and what should you give in an overdose?

Answer 10

TCA - IV bicarbonate

Question 11

What antibiotic is contraindicated in G6PD deficiency?

Answer 11

Ciprofloxacin