Pharmacology Exam 3 Flashcards
When monitoring a patient who is taking a systemically administered glucocorticoid, the nurse should monitor for signs of:
Hypokalemia
A patient is receiving aminoglutethimide (Cytadren) therapy. The nurse knows that this medication is used for which condition?
Cushing’s Syndrome
A patient is taking fludrocortisone for Addison’s disease, and his wife is concerned about all the problems that may occur with his therapy. When teaching them about therapy with this drug, the nurse should include which information?
It should be taken with food or milk to minimize GI upset
A patient is concerned about the body changes that have resulted from long-term prednisone therapy for the treatment of lupus erythematosus. Which of the following effects of this drug therapy would be present to support the nursing diagnosis of disturbed body image?
Weight gain
When starting drug therapy with corticosteroids, the nurse is aware that some drugs can have adverse interactions with corticosteroids, such as:
NSAIDs
The nurse is administering lispro insulin, and should keep in mind that this insulin is:
a rapid-acting insulin
When teaching about hypoglycemia, the nurse should make sure that the patient is aware of the early signs of hypoglycemia, which are:
irritability and confusion
The nurse is teaching a group of patients about self-administration of insulin. What teaching is important to include?
when mixing insulins, the clear (such as Regular) insulin should be drawn up into the syringe first
A patient who has type II diabetes is scheduled for a laparoscopy and has been NPO since midnight. She is concerned about her medications being held. What is the best action regarding the administration of her oral anti diabetic drug?
contact the Physician for further orders
When taking a rapid-acting insulin such as insulin aspart, which of the following is correct regarding administration?
It should be taken within 15 minutes of beginning a meal
A patient has been prescribed warfarin (Coumadin) in addition to a heparin infusion. The nurse recognizes that the reason for the two anticoagulants is which of the following?
Heparin is often used to initiate therapy when oral anticoagulants are prescribed until laboratory tests indicate an adequate therapeutic response
During thrombolytic therapy, the nurse monitors the patient for adverse effects. What is the most frequent undesirable effect of thrombolytic therapy?
Internal and superficial bleeding
A patient has received too much warfarin. The nurse would expect to give which antidote for wafarin toxicity?
Vitamin K
Which of the following is true for the patient receiving long-term aspirin therapy?
Laboratory studies should be done to monitor liver, renal, and clotting functions
A patient is receiving an intravenous infusion of heparin. Which of the following laboratory studies will be used to adjust and monitor the dose of heparin?
aPTT (activated partial thromboplastin time)
A patient arrives in the emergency department with sever chest pain. She says she has had pain off and on for a week now. Which assessment finding would indicate the need for cautious use of nitrates and nitrites?
Blood Pressure of 98/68 mm Hg
A calcium channel blocker (CCB) is prescribed for patient , and the nurse provides instructions to the patient about the medication. What does the nurse tell the patient?
A high-fiber diet with plenty of fluids will help prevent the constipation that may occur
A patient about to receive his morning does of digoxin has an apical pulse of 70 bpm. What will the nurse do?
Administer the dose
A patient has been taking digoxin at home but has taken an accidental overdose and has developed toxicity. He has been admitted to the telemetry unit where the physician has ordered digoxin immune Fad (Digibind). The patient asks the nurse why the medication is ordered. What us the nurse’s best response?
“This drug is an antidote to digoxin and will help to lower the blood levels.”
While assessing a patient who is taking a beta-blocker for angina, the nurse knows to monitor for which adverse effect?
Bradycardia (under 60 bpm)
Break down clots
Thrombolytic Drugs
activate plasminogen & convert it to plasmin, which can digest fibrin
Thrombolytic Drugs
alteplase (Activase)
Thrombolytic Drug
an enzyme that naturally occurs in the blood stream
alteplase (Activase)
“t-PA”
alteplase (Activase)
Half life of alteplase (Activase)
5 minutes –> constant infusion
main treatment of alteplase (Activase)
stroke
acute MI, pulmonary embolism, acute ischemic stroke, clogged arterial lines [Cathflo-Activase]
2 Types of strokes
- Clot
2. Blow out of blood vessel
streptokinase (Streptase)
Thrombolytic Drug
produced from beta-hemolytic strep
streptokinase (Streptase)
main treatment of streptokinase (Streptase)
DVT
acute MI, pulmonary embolism
Prevents platelet adhesion at the site of blood vessel injury
Anti-Platelets
Once injury occurs –> platelets change shape
Anti-Platelets
aspirin (Acetylsalicylic Acid)
Anti-Platelet
The most common dose of this drug is 81mg/day
aspirin (Acetylsalicylic Acid)
Long-term use of this drug requires monitoring of liver, renal, and clotting function
aspirin (Acetylsalicylic Acid)
DO NOT give this drug to children, it can result in Reyes Syndrome
aspirin (Acetylsalicylic Acid)
This drug has the following adverse effects:
GI Bleeding, Diarrhea, Flushing, Dizziness
(heart burn, bleeding)
aspirin (Acetylsalicylic Acid)
main treatment of aspirin (Acetylsalicylic Acid)
MI –> 81 mg/day
stroke –> 325 mg/day
(anti-inflammatory, analgesic, antipyretic)
clopidogrel (Plavix)
Anti-Platelet
This drug has the following adverse effects:
chest pain, flulike symptoms, dyspepsia (heart burn), abdominal pain, epistaxis (nose bleeds), bleeding, chills
clopidogrel (Plavix)
main treatment for clopidogrel (Plavix)
- arthrosclerotic events (stiff joints) –>75 mg/day
- post stent replacement –> 300 mg/day
- stroke
- transient ischemic attack
- post MT (thrombi-prevention)
eptifibatide (Intergrillin)
Anti-Platelet Drug given IV
An Antiplatelet drug only given in an ICU setting
eptifibatide (Intergrillin)
When administering eptifibatide (Intergrillin) you must monitor:
heart monitor at all times
Main treatment for eptifibatide (Intergrillin)
unstable angina or cardiac catheterization lab
MI
inhibits formation of clotting factors but not on a clot that has already formed
anticoagulants
Indications that an anticoagulant drug is needed:
- MI
- Unstable angina
- A-Fib (pooling in R atrium [sometimes in L])
- indwelling devices (heart valve)
- major ortho surgery (femur/hip fracture)
Heparin
Anticoagulant
Concentrations of this drug can vary from 10 units to 40,000 units
Heparin
Half life of Heparin
1 - 2 hours
Monitoring of aPTT or PTT is a must with this drug
Heparin
antidote of this drug is protomine sulfate
Heparin
warfarin (Coumadin)
Anticoagulant
this anti-coagulant is the most commonly prescribed
warfarin (Coumadin)
This anti-coagulant is only given PO
warfarin (Coumadin)
monitoring of PT and INR is a must with this drug
warfarin (Coumadin)
goal of Heparin is:
aPTT 1.5 - 2.5 times the normal value
aPTT normal times are:
30 - 40 seconds
PTT normal times are:
50 - 70 seconds
PT normal times:
11 - 13 seconds
INR (international normalized ratio):
2 - 3
Goal on warfarin (Coumadin)
INR = 3.5
Antidote of warfarin (Coumadin)
Vitamin K
enoxaparin (Lovenox)
Anticoagulant
aka: low molecular weight heparin (LMWH)
enoxaparin (Lovenox)
this drug is fractionated heparin –> the smaller fragments have higher a attraction (affinity)
enoxaparin (Lovenox)
a pt can go home on this fractionated form of heparin
enoxaparin (Lovenox)
enoxaparin (Lovenox) has a longer half-life than heparin does, why is this beneficial?
enoxaparin (Lovenox) has a more predictable anticoagulant response
Anticoagulants
Coagulation Modifier Drug
Antiplatelets
Coagulation Modifier Drug
Thrombolytic Drugs
Coagulation Modifier Drug
Baseline vitals will ________ on Coagulation Modifier Drug
decrease
HR will increase
Platelet counts are important with this drug:
aspirin (Acetylsalicylic Acid)
During Assessment History of abnormal bleeding is important with which type of drugs?
Coagulation Modifier Drugs
Coagulation Modifier Drugs are what kind of medication
High Alert!
With high alert medications what 3 things should a nurse do with another nurse?
- Check Medication
- Check Calculation
- Check Pump
What drug is involved in NOT aspirating before administration?
Heparin
What drug do you NOT massage into muscle after aspiration?
Heparin
While administering what drug do you NOT want to pinch the muscle?
Heparin