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First Aid - Neurology > Pharmacology - Epilepsy Drugs > Flashcards

Pharmacology - Epilepsy Drugs Flashcards

1
Q

Mechanism: Ethosuximide

A

Blocks thalamic T-type Ca++ channels

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2
Q

Side effects: Ethosuximide [5]

A 
Fatigue
GI distress
Headache 
Itching (and urticaria)
Stevens-Johnson syndrome
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3
Q

Use: Ethosuximide

A

Absence = 1st line

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4
Q

Mechanism: BDZs (Diazepam, Lorazepam, Midazolam)

A

Increase GABAa action

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5
Q

Side effects: BDZs (Diazepam, Lorazepam, Midazolam)

[4]

A

Sedation
Tolerance
Dependence
Respiratory depression

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6
Q

Use: BDZs (Diazepam, Lorazepam, Midazolam)

A 
Status epilepticus - 1st line for acute
Eclampsia seizures (2nd line; 1st - MgSO4)
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7
Q

Mechanism: Phenobarbital

A

Increase GABAa action

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8
Q

Side effects: Phenobarbital

A 
Sedation 
Tolerance
Dependence
P450 inducer
CV depression
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9
Q

Use: Phenobarbital

A

First-line in neonates:
Partial
Tonic-clonic

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10
Q

Mechanism: Phenytoin, Fosphenytoin

A

Blocks Na+ channels

Zero-order kinetics

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11
Q

Side effects: Phenytoin, Fosphenytoin

[10]

A 
Neurologic - nystagmus, diplopia, ataxia
Hirsutism
Stevens-Johnson syndrome
Gingival hyperplasia
DRESS syndrome
Osteopenia
SLE-like syndrome
Megaloblastic anemia
Teratogen - fetal hydantoin syndrome
P450 inducer
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12
Q

Use: Phenytoin, Fosphenytoin

A

Partial
Tonic-clonic - 1st line
Status epilepticus - 1st line for prophylaxis

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13
Q

Mechanism: Carbamazepine

A

Blocks Na+ channels

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14
Q

Side effects: Carbamazepine [7]

A 
Neurologic - diplopia, ataxia
Blood dyscrasias (agranulocytosis, aplastic anemia)
Liver toxicity
SIADH
Stevens-Johnson syndrome
Teratogenesis
P450 inducer
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First Aid - Neurology (6 decks)

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