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Pharmacology > Pharmacology - Block 2 > Flashcards

Pharmacology - Block 2 Flashcards

1
Q

Serotonin synthesis

A

Tryptophan - tryptophan hydroxylase (rate limiting, except in CNS) (need O2 and pteridine cofactor) -> 5-hydroxytryptophan - L-aromatic amino acid decarboxylase (needs pyridoxine cofactor) -> Serotonin (5HT)
- (in pineal gland)-> Melatonin

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2
Q

Serotonin metabolism

A 
Monoamine Oxidase (MAO)
SERT = high affinity reuptake
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3
Q

5-HT1 receptors

A

Gi - inhibits AC, opens K+ channels

A,B,D,E

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4
Q

5-HT2 receptors

A

Gq - PLC -> PIP3->GAP,IP3

A,B,C

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5
Q

5-HT 4,5,6,7

A

Gs - activate AC

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6
Q

5-HT3 receptors

A

Ligand gated cation channel

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7
Q

Serotonin auto-receptors

A

decrease serotonin release

1A and 1D like

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8
Q

Serotonin -> GI

A

slow turnover (1 day)
causes contraction of GI smooth muscle
5-HT3 -> vomiting
carcinoid syndrome = serotonin secreting tumor -> also can get vitamin deficiency bc depletes tryptophan

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9
Q

Serotonin -> CV

A

Vasoconstriction or dilation depending
large arteries + cranial vessels = vasoconstrict (5HT2 on smooth muscle cells, 5HT1D in brain, also indirect by NE displacement)
Arterioles, coronaries, skeletal m = vasodilation
Bezold-Jarisch reflex = serotonin- chemoreceptors in coronaries -> vagal nerve endings -> bradycardia, hypotension, hypoventilation

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10
Q

Serotonin -> CNS

A

Neurotransmitter -> midbrain raphe nucleus

sensory perception, sleep, temp, endocrine, pain, drug abuse, emesis, mental illness

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11
Q

Serotonin-related mental illness

A 
affective disorders - SSRI, SNRI
schizophrenia - atypical anti-psychotics
OCD - SSRI
anxiety - 5-HT1A
aggressive behavior
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12
Q

Lysergic Acid Diethylamide

A

LSD - hallucinogen

5HT2 agonist

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13
Q

Buspirone

A

5HT1A partial agonist

anti-anxiety

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14
Q

Sumatriptan

A

5HT1D agonist
anti-migraine (stop existing headache)
side effects = nausea, vomiting, dizziness

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15
Q

Fluoxetine

A

“Prozac”
SSRI
used for affective disorders, OCD, panic, etc
side effects = sex dysfunction, nausea, etc

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16
Q

Phenelzine

A 
MAO inhibitor
Blocks metabolism of serotonin, NE, DA
Used for depression, narcolepsy
Last ditch effort
side effects = food induced hypertensive crisis
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17
Q

Cyproheptadine

A

5HT2 antagonist
Also Histamine H1 antagonist
treats skin allergies, carcinoid

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18
Q

Ondansetron

A

5HT3 antagonist
treats chemotherapy induced nausea
acts on GI and brain receptors

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19
Q

Alosetron

A

5HT3 antagonist
last ditch treatment for women with diarrhea IBS
has GI side effects

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20
Q

Histamine synthesis

A

L-histidine - histidine decarboxylase (inducible) (uses pyridoxal-5-P cofactor)-> Histamine (inhibited by methyl-histidine)

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21
Q

Histamine pools

A 
Mast cells (tissue) and basophils (blood) - slow turnover, stored in secretory granules with heparin sulfate and ATP
Non-Mast cell stores - rapid turnover, no granules, continuous release
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22
Q

Release of histamine

A

w/i seconds = burning, itching, up HR, down BP
w/i minutes = BP recovers, hives on skin
antigen-antibody reaction
drugs, venoms, etc can cause release
Vancomycin-induced ‘red-man’ syndrome
mechanism = increase intracellular Ca in mast cells

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23
Q

Cromolyn sodium

A

Inhibit histamine release
stabilizes mast cell membranes
inhaled
used for asthma, allergies

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24
Q

Omalizumab

A 
inhibit histamine release
monoclonal antibody decreases antigen specific IgE that binds to mast cells
subcutaneous
can cause life-threatening anaphylaxis
used to treat extreme allergic asthma
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25
Q

H1 receptor

A

Gq

smooth muscle, endothelial cells, CNS

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26
Q

H2 receptor

A

Gs

gastric parietal cells, cardiac muscle, mast cells, CNS

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27
Q

Histamine -> CV

A

Overall decrease BP
vasodilation
endothelial cells - H1 -> NO
smooth muscle - H2 -> cAMP
can vasoconstrict large vessels (H1)
Increase vascular permeability - H1 on venules -> endothelial cells contract, expose basement membrane
increase contractility, electricals in heart (H2)

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28
Q

Histamine -> pulmonary, GI, Neuro

A 
Bronchioles - contract (H1)
intestinal smooth muscle - contract (H1)
GI secretion - increase (H2)
Nerve endings - pain (H1)
Triple Response of Lewis = red line, red flare, wheal
H1= arousal
H2= decrease apetite
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29
Q

Diphenhydramine

A

1st gen H1 blocker
Benadryl, profound sedation
used for allergies, motion sickness, Parkinsons

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30
Q

Dimenhydrinate

A

1st gen H1 blocker
Dramamine
used for motion sickness and vestibular disturbance

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31
Q

Chlorpheniramine

A

1st gen H1 blocker

used for allergies, potent, some sedation

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32
Q

Promethazine

A

1st gen H1 blocker
also blocks dopamine
Phenergan
used for motion sickness and anti-nausea

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33
Q

Fexofenadine

A

2nd gen H1 blocker

Allegra

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34
Q

Loratadine

A

2nd gen H1 blocker

Claritin

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35
Q

Desloratadine

A

2nd gen H1 blocker

Clarinex

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36
Q

Cetirizine

A

2nd gen H1 blocker

Zyrtec

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37
Q

1st vs 2nd generation H1 blockers

A

1st: have sedative and anticholinergic side effects / CNS depression is common, some can be used to treat motion sickness bc anticholinergic
2nd: no anticholinergic or sedative effects, do not cross BBB into CNS / usually metabolized by liver P450s

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38
Q

Cimetidine

A

H2 receptor blocker
used for gastric upset / peptic ulcers
Inhibits P450 enzymes
Tagamet (least potent)

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39
Q

Ranitidine

A

H2 receptor blocker
used for gastric upset / peptic ulcers
Zantac

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40
Q

Famotidine

A

H2 receptor blocker
used for gastric upset / peptic ulcers
Pepcid (most potent)

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41
Q

Effects of inflammation

A

vasodilation, increased vessel permeability, pain

harmful: inflammatory cells release lysosomal enzymes, swelling can cause death, obstruction

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42
Q

Bradykinin

A

source: endothelial cells

vasodilation, velles permeability, pain

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43
Q

Complement system

A

Synthesized in liver, circulates in blood

chemotaxis, vascular permeability, promote mediator release from neutrophil

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44
Q

C-reactive protein

A

produced in liver in response to cytokines
acute phase reactant
activates complement / phagocytosis

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45
Q

Cytokines

A

Source: all inflammatory cells
TNFa: acute phase rxn, fever
IL-1: acute phase rxn, fibroblast and lymphocyte proliferation, fever
(increase COX and lipoxygenases)
increase adhesion molecules and collagenase

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46
Q

Etanercept

A

TNFa blocker
not orally active, risk of infection
used for rheumatoid arthritis

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47
Q

Infliximab

A

TNFa blocker
not orally active, risk of infection
used for rheumatoid arthritis

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48
Q

Adenosine

A

source: all cells
anti-inflammatory
inhibits cytokines

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49
Q

Cell adhesion molecules

A

Source: endothelial cells, platelets, leukocytes
important for host defense, tissue repair, and recruiting platelets
Ca dependent

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50
Q

Zileuton

A

5-lipoxigenase inhibitor (5-LOX)
inhibits leukotriene synthesis
oral, CYP metabolized
use for prophylactic treatment of mild asthma

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51
Q

Zafirlukast

A

cys-leukotriene receptor antagonist
oral, CYP metabolized
use for prophylactic treatment of mild asthma

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52
Q

Glucocorticoids

A

Source: adrenal cortex
anti-inflammatory
inhibit cytokines, PLA2, COX2, cell adhesion molecules
nuclear receptors

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53
Q

Aspirin

A

NSAID

inhibits COX

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54
Q

Synthesis of eicosanoids

A

phospholipids - PLA2 -> Arachidonic acid (Ca dependent)

    • LOXs-> leukotrienes, lipoxins
    • COXs-> prostaglandins

RAPID inactivation

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55
Q

COXs

A 
COX1: constitutive
COX2: inducible (important)
1. oxygenates to form PGG2
2. peroxidase to PGH2
PGH2 -> PGI2, TXA2, PGE2, PGF2
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56
Q

Lipoxygenases

A

5-LOX -> leukotrienes

requires Ca and FLAP

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57
Q

Eicosanoids -> pain

A

PGE2, PGI2 -> hyperalgesia

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58
Q

Eicosanoids -> fever

A

cytokines-> PGE2->cAMP->fever

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59
Q

Eicosanoids -> platelets

A

TXA2 -> platelet aggregation

PGI2 -> inhibits platelet aggregation

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60
Q

Eicosanoids -> uterus

A

PGI2 = early pregnancy
PGE2: labor, ripening
PGF2: labor, contractility (also dysmenorrhea)

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61
Q

Eicosanoids -> CV

A 
Prostaglandins-> usually decrease BP
PGE, PGI2 -> vasodilators
TXA2, PGF2: vasoconstrictor
mostly local effects
PGE2 -> ductus arteriosis
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62
Q

Eicosanoids -> bronchial

A

primarily bronchoconstrictor response to leukotrienes

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63
Q

Eicosanoids -> kidney

A

PGE2, PGI2 -> increase renal blood flow

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64
Q

Eicosanoids -> GI

A

Generally cytoprotective
PGE2 mostly
decrease gastric acid, increase mucus, etc

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65
Q

Eicosanoids -> immune

A

LTC4, LTD4 -> increase vascular permeability

LTB4 -> attracts neutrophils

66
Q

Dinoprostone

A 
PGE2 analog
used for cervical ripening (gel)
EP4 - also relaxes cervial muscle
can use for abortion at high doses
EP1/3
67
Q

Misoprostol

A

PGE1 analog
used for ulcer prevention with long-term NSAID use
EP3 in parietal cells -> less gastric acid

68
Q

Alprostadil

A 
PGE1
use for erectile dysfunction (injection)
EP2/4
Also used for patent ductus arteriosis (IV)
EP2/4
69
Q

Epoprostenol

A

PGI2
used for pulmonary hypertension
IV, IP receptor

70
Q

Bimatoprost

A

PGF2
used for glaucoma and eyelash hypotrichosis
ophthalmic soln
EP2/4

71
Q

Acetylsalicylic adic

A 
Aspirin
NSAID
IRREVERSIBLE COX inhibitor
quickly metabolized to salicylic acid
high dose can saturate conjugation -> toxicity
Low dose: decrease uric acid excretion
high dose: increase uric acid excretion
Overdose: delirium, up respirations, nausea
Reye's syndrome in kids
72
Q

NSAID side effects

A

GI (major): gastric ulcers/bleeding
blood: increased bleeding (platelets)
hypersensitivity: due to shunting toward lipoxygenase->leukotrienes
Renal: decrease RBF
Pregnancy: Contraindicated (decrease contractions, ductus arteriosis

73
Q

Ibuprofen

A

NSAID

used as usual, also for patent ductus arteriosis

74
Q

Naproxen

A

NSAID
longer half life
used for usuals plus arthritis, dysmenorrhea, etc

75
Q

Indomethacin

A

NSAID

Used for acute gouty arthritis, other arthritis, not usually pain/fever

76
Q

Ketorolac

A

NSAID

analgesic and anti-pyretic, not anti-inflammatory

77
Q

Nabumetone

A 
NSAID
COX2>Cox1
prodrug
anti-inflammatory and analgesic
less side effects
78
Q

Piroxicam

A

NSAID
long half life
usual uses

79
Q

Sulfasalazine

A

used to treat active ulcerative colitis, and arthritis

local GI effects to inhibit inflammation

80
Q

Celecoxib

A

COX2 selective NSAID
Contains sulfa moity
metabolized by P450s
has usual NSAID side effects and usage

81
Q

Acetaminophen

A

Tylenol
mechanism not known
Metabolized by P450s, toxicity effects
analgesic and anti-pyretic, not anti-inflammatory
OD treatment: N-acetylcysteine to replace glutathione

82
Q

Nitroglycerin

A

NO donor
venous dominant vasodilator (but both)
use in heart failure

83
Q

Nitroprusside

A

Similar to nitroglycerin

84
Q

Hydralazine

A

increase cGMP
arterial dominant vasodilator
used in heart failure

85
Q

Minoxidil

A

K channel opener
arterial dominant vasodilator
used in heart failure and hypertension

86
Q

Diazoxide

A

K channel activator

used in hypertension

87
Q

Verapamil

A 
Phenylalkylam
Ca channel blocker
arterial dominant vasodilator
reduce afterload
cardiac cell dominant
used for arrhythmias
substancial first-pass effect
88
Q

Diltiazem

A 
Benzothiazapine
Ca channel blocker
arterial dominant vasodilator
reduce afterload
cardiac cell dominant
used for arrhythmias and angina
89
Q

Milrinone

A

PDE3 inhibitor
cAMP-PDE3->AMP
in Cardiac m: cAMP causes contraction (P Ca channels and myofilaments, also P K channels to increase rate)
in Vascular SM: cAMP causes relaxation (inhibits MLC-Kinase and P K channels)
used in heart failure

90
Q

Inamrinone

A

PDE3 inhibitor
cAMP-PDE3->AMP
in Cardiac m: cAMP causes contraction (P Ca channels and myofilaments, also P K channels to increase rate)
in Vascular SM: cAMP causes relaxation (inhibits MLC-Kinase and P K channels)
used in heart failure

91
Q

Cilostazol

A

PDE3 inhibitor
cAMP-PDE3->AMP
in Cardiac m: cAMP causes contraction (P Ca channels and myofilaments, also P K channels to increase rate)
in Vascular SM: cAMP causes relaxation (inhibits MLC-Kinase and P K channels)
used in heart failure

92
Q

Sildenafil

A

PDE5 inhibitor
cGMP-PDE5->GMP
cGMP: smooth muscle relaxation
used for erectile dysfunction

93
Q

Tadalafil

A

PDE5 inhibitor
cGMP-PDE5->GMP
cGMP: smooth muscle relaxation
used for erectile dysfunction

94
Q

ACE inhibitors

A

Decrease Angiotensin II and increase bradykinin

vasodilate, use in hypertension

95
Q

Fenoldopam

A

Dopamine A1 receptor agonist
increase cAMP -> vasodilate
use in hypertensive crisis
b/c strong RBF dilator -> diuretic

96
Q

Prazosin

A

alpha adrenergic blocker

vasodilation

97
Q

Albuterol

A

B2 agonist
cAMP/PKA
bronchodilator

98
Q

Pirbuterol

A

B2 agonist
cAMP/PKA
bronchodilator

99
Q

Tertbutaline

A

B2 agonist
cAMP/PKA
bronchodilator

100
Q

Salmeterol

A

B2 agonist
cAMP/PKA
bronchodilator

101
Q

Formoterol

A

B2 agonist
cAMP/PKA
bronchodilator

102
Q

Ipratropium

A

anti-cholinergic (muscarinic)

bronchodilator / inhibit mucus

103
Q

Tiotropium

A

anti-cholinergic (muscarinic)

bronchodilator / inhibit mucus

104
Q

Theophylline

A

PDE inhibitor
adenosine receptor antagonist
bronchodilator

105
Q

Aminophylline

A

PDE inhibitor
adenosine receptor antagonist
bronchodilator

106
Q

Aldosterone

A

glucocorticoid (0.2:250 anti-inflam:Na retention)
Made in Zona glomerulosa of adrenal
controlled by angioitensin II and K

107
Q

Cortisol

A

glucocorticoid (1:1 anti-inflam:Na retention)
Made in Zona fasciculata and reticularis of adrenals
Controlled by ACTH

108
Q

Glucocorticoid effects

A 
Increases plasma glucose
Increases liver glycogen
Stimulates amino acid mobilization
Redistribute body fat (moon face)
Sleepiness
Mineralocorticoid effects (increase Na reabsorbtion, increase K secretion, hypertension)
Lymphosytopenia and monocytopenia (redistribution)
Prevent neutrophil adherence
Inhibit chemotaxis
Inhibits IL-1 and IL-2 release
Inhibits arachidonic acid release
Inhibits COX2 (via cytokines)
109
Q

Glucocorticoid uses

A 
Adrenal insufficiency
rheumatoid arthritis
osteoarthritis
allergies
inflammation
organ transplant
etc
Contraindications: infection, esp TB
110
Q

Dexamethasone

A

glucocorticoid (20:0 anti-inflam:Na retention)

111
Q

Prednisolone

A

glucocorticoid (3:0.8 anti-inflam:Na retention)

112
Q

Fludrocortisone

A

glucocorticoid (12:100 anti-inflam:Na retention)

113
Q

Metyrapone

A

glucocorticoid inhibitor
blocks 11-B-hydroxylation
leads to increase ACTH
Used as diagnostic for feedback loop

114
Q

Mifepristone

A

glucocorticoid inhibitor
Progesterone and glucocorticoid receptor antagonist
used for termination of pregnancy and to treat Cushing’s

115
Q

Spironolactone

A

Mineralocorticoid/aldosterone antagonist
K-sparing diuretic, weak (acts in distal tubule)
anti-hypertension, often used with a thiazide or loop diuretic
long duration
anti-heart failure
side effect= hyperkalemia

116
Q

Eplerenone

A

Mineralocorticoid/aldosterone antagonist
K-sparing diuretic, weak (acts in distal tubule)
anti-hypertension, often used with a thiazide or loop diuretic
long duration
anti-heart failure
side effect= hyperkalemia

117
Q

Drospirenone

A

Progesterone, mineralcorticoid, androgen receptor antagonist
diuretic
used w/ estrogen for hormone replacement and to suppress ovulation

118
Q

Azathioprine

A 
cytotoxic anti-immune drug
metabolized to 6-MP
inhibits purine biosynthesis
inhibits both de novo and salvage
used for organ transplant and some autoimmune
119
Q

Cyclophosphamide

A

cytotoxic anti-immune
cross-links DNA
most toxic to B-cells
used for auto-immune

120
Q

Methotrexate

A

cytotoxic anti-immune
inhibits folate in purine synthesis (DNA synthesis)
used to treat auto-immune

121
Q

Mycophenolate Mofetil

A 
cytotoxic anti-immune
more selective
inhibits IMP dehydrogenase (de novo pathway only, not salvage)
lymphocyte specific
used for auto-immune
122
Q

Cyclosporine

A

Blocks NFAT, which blocks IL-2 production
not lymphotoxic, more selective
used for organ transplant and some auto-immune
nephrotoxicity side effect

123
Q

Tacrolimus

A

More potent cyclosporine

less side effects

124
Q

Sirolimus

A

Inhibits T-cell activation downstream of IL-2
Inhibits mTOR
similar to cyclosporine
also used to coat cardiac stents

125
Q

Aliskiren

A

Inhibits renin

used for hypertension, no effect on heart rate

126
Q

Captopril

A

ACE inhibitor
used for hypertension, no effect on heart rate
decreases afterload

127
Q

Enalapril

A

ACE inhibitor
used for hypertension, no effect on heart rate
decreases afterload

128
Q

Lisinopril

A

ACE inhibitor
used for hypertension, no effect on heart rate
decreases afterload

129
Q

Propranolol

A

B-blocker

reduces renin release

130
Q

Metoprolol

A

B-blocker

reduces renin release

131
Q

Actions of Angtiotensin II

A

AT1 receptors = vasoconstriction, aldosterone, etc (Gq)
AT2 = vasodilation
Vascular SM - AT1 dominant
Stimulates aldosterone and ADH and NE

132
Q

Losartan

A

AT1 receptor antagonist (AngII)
used for hypertension, no effect on heart rate
decreases afterload
contraindicated in pregnancy

133
Q

Nifedipine

A 
1,4-Dihydropyridine
Ca channel blocker
reduce afterload
arterial dominant
used with B-clickers for hypertension
134
Q

Amlodipine

A 
1,4-Dihydropyridine
Ca channel blocker
reduce afterload
arterial dominant
used with B-clickers for hypertension
135
Q

Dopamine

A

Vasodilator diuretic

increase RBF

136
Q

Atriopeptins

A

Vasodilator diuretic

increase RBF

137
Q

Mannitol

A

Osmotic diuretic
must be IV
sort of last-ditch
enhanced K excretion

138
Q

Acetazolamide

A 
Carbonic anhydrase inhibitor diuretic
OAT
decreases bicarbonate reabsorbtion
urine pH increases
K secretion increases
used for glaucoma, to alkalinize urine, altitude sickness
side effect = metabolic acidosis
139
Q

Furosemide

A

‘Lasix’ - Loop diuretic
OAT
inhibits Na-K-Cl symporter in ascending limb
potent, fast acting, short lived
increases Na-K exchange
used for edema and hypertension
side effects= hypokalemia, hyperuricemia, hyperglycemia

140
Q

Bumetanide

A

Loop diuretic

like furosemide

141
Q

Ethacrynic acid

A

Loop diuretic

like furosemide

142
Q

Hydrochlorothiazide

A 
Thiazide diuretic
OAT
Inhibits Na-Cl symporter in ascending limb
intermediate activity, long lasting
excrete hypertonic urine
used for edema and hypertension
side effects= hypokalemia, hyperuricemia, hyperglycemia
contraindicated in renal failure
143
Q

Chlorothiazide

A

Thiazide diuretic

144
Q

Metolazone

A

Thiazide diuretic

145
Q

Triamterene

A 
K-sparing diuretic
Na-channel blocker in principal cells
thus Na-K exchange is blocked
used for hypertension with other diuretics and edema
side effect= hyperkalemia
146
Q

Amiloride

A 
K-sparing diuretic
Na-channel blocker in principal cells
thus Na-K exchange is blocked
used for hypertension with other diuretics and edema
side effect= hyperkalemia
147
Q

Heparin

A

Unfractionated
heterogenous mixture of large neg charged peptides
catalyzes inhibition of several coagulation factors via antithrombin (including thrombin and Xa)
it does not affect synthesis of clotting factors
LMWH: (low molecular weight) - does not inhibit thrombin, just Xa
must be given IV or subcu
does not cross placenta
rapid action, complex half-life
monitor action using aPTT
used for immediate thrombosis treatment or surgical bipass prophylaxis
side effect: bleeding and Heparin-induced thrombocytopenia (drop in platelets, due to antibody production)

148
Q

Enoxaparin

A

Low molecular weight heparin
longer half life, subcu admin
more predictable

149
Q

Dalteparin

A

Low molecular weight heparin
longer half life, subcu admin
more predictable

150
Q

Lepirudin

A

direct thrombin inhibitor
IV admin
used for pts with heparin-induced thrombocytopenia

151
Q

Protamine Sulfate

A

heparin antagonist
positively charged, low molecular weight
used to reverse heparin after cardiopulmonary bypass

152
Q

Warfarin

A

Inhibits VKORC1
VKORC1 converts vitamin K to it’s active form (KO->KH2), which is required for activation of clotting factors II, VII, IX, and X.
therapeutic effect is delayed hours to days bc existing factors are unaffected
Metabolized by CYP2C9
It does cross placenta
Normal INR= .8-1.2
Warfarin INR= 2-3
used for long-term prophylaxis for thrombosis/thromoembolism

153
Q

Dabigatran

A

anti-coagulant
prodrug, reversible direct thrombin inhibitor
not monitored
shorter half-life
few adverse rxns, except with altered P-glycoprotein
used similar to warfarin

154
Q

Rivaroxaban

A 
Anti-coagulant
Inhibits Xa, once-daily
P450 metabolized
few adverse rxns, except with altered P-glycoprotein
no monitoring
used similar to warfarin
155
Q

Alteplase

A 
Tissue Plasminogen activator (t-PA)
Thrombolytic
Binds to fibrin, activates plasminogen to plasmin, which initiates clot resolution (degrades fibrin)
given IV, expensive
used for STEMI and ischemic stroke
156
Q

Aminocaproic acid

A

Procoagulant
inhibitor of fibrinolysis (inhibits plasmin)
used for decreasing hemorrage in surgery

157
Q

Aspirin

A

low dose= anti-platelet
used for MI prophylaxis
COX1,2 inhibitor in platelets, thus blocks thromboxane formation

158
Q

Dipyramidole

A

Anti-platelet
phosplodiesterase inhibitor, increases cAMP, which inhibits platelet aggregation
used with warfarin to prevent thromboemboli

159
Q

Ticlopidine

A

Similar to Clopidogrel but used less

160
Q

Clopidogrel

A

Anti-platelet
blocks ADP-receptor (P2Y1->Gi)
leads to increased cAMP
activated by CYP2C19

161
Q

Abciximab

A

anti-platelet
prevents binding of clotting factors to the GPIIb/IIIa receptor on activated platelets
given IV
used adjunct to percutaneous coronary intervention

Pharmacology (8 decks)

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