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CPR > Pharmacology: ANCA Vasculitis and Goodpasture's Syndrome > Flashcards

Pharmacology: ANCA Vasculitis and Goodpasture's Syndrome Flashcards

1
Q

cyclophosphamide MOA

A

alkylating agent

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2
Q

cyclophosphamide indications

A
  • MCD in pediatric patients

- malignant diseases

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3
Q

cyclophosphamide limitations

A

safety and effectiveness for treatment of nephrotic syndrome in adults or other renal disease has not been established

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4
Q

cyclophosphamide warnings

A
  • cardiotoxicity
  • pulmonary toxicity
  • veno-occlusive liver disease
  • embryo-fetal toxicity
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5
Q

rituximab MOA

A

CD20-directed cytolytic Ab

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6
Q

rituximab indications

A

NHL, CLL, RA (combo w/ MTX)

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7
Q

rituximab BB warnings

A
  • fatal infusion reactions
  • TLS
  • severe mucocutaneous reactions
  • PML
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8
Q

rituximab causes renal toxicity when combined with

A

cisplatin

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9
Q

azathioprine indications

A
  • adjunct for prevention of rejection in renal homotransplantation
  • active RA
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10
Q

malignancy patients receiving immunosuppressants, including azathioprine, are at increased risk of developing lymphoma and other malignancies, particularly of the…

A

skin

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CPR (3 decks)

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