Pharmacology

Question 1

Heparin

Answer 1

• Glycosaminoglycan
• Binds to antithrombin and increases its activity (indirect thrombin inhibitor)
• Given by continuous infusion
• used for abnormal blood clotting (DVT, PE)

Question 2

LMWH

Answer 2

• Once daily, weight-adjusted dose given subcutaneously

- Used for treatment and prophylaxis of abnormal blood clotting

Question 3

aspirin

Answer 3

• inhibits cyclo-oxygenase irreversibly

- Inhibits thromboxane formation and hence platelet aggregation

Question 4

warfarin

Answer 4

• Prevents synthesis of active factors II, VII, IX and X
• Antagonist of vitamin K
• Prolongs prothrombin time

Question 5

Direct oral anticoagulant drugs (DOACs)

Answer 5

• Directly acting on factor II and X
• No blood test or monitoring
• Used for extending thromboprophylaxis
• Not used in pregnancy