Pharmacology Flashcards
What is Mebeverine?
Antispasmodic used for IBS
What is Loperamide?
Antidiarrhoeal used for acute non-infective diarrhoea
What is Prednisolone?
Anti-inflam used for UC
What is Cinchocaine (+ hydrocotisone)
?
Combo used for haemorrhoids
What is the MOA of Mebeverine?
Can reduce Ca in colonic SMCs = less painful spasm
What is the MOA of Loperamide?
Mu-opioids receptor agonist in myenteric plexus which suppresses innervation of GI smooth muscles
What is the MOA of Prednisolone?
Glucocorticoids analogue complexes with receptor = transcriptionally down reg inflam
What is the MOA of Cinchcaine?
Local anaesthetic
Blocks VG Na channels in nociceptive nerve fibers reducing pain sensation
What are the ADR’s of Mebeverine?
Constipation
Indigestion
Rash
Urticaria
What are the CI’s of Mebeverine?
Pre-existing paralytic ileus
What are the ADR’s of Loperamide?
Dizziness
Flatulence
Nausea
Headache
What are the CI’s of Loperamide?
Ulcerative or bacterial colitis
What are the ADR’s of Prednisolone?
Cushings
Weight gain
Immuno + adrenal suppression
What are the CI’s of Prednisolone?
If cushings or immunosuppressed or active infection
What are the ADR’s of Cinchocaine?
Bradyarrhythmias, hypotension, CNS effects
If heart block or WPW arrhythmias
