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Dafna's Flashcards > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Dopamine D2 antagonism or partial agonism leads to …

A

Decreased positive sx

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2
Q

Serotonin 5HT1a partial agonist leads to

A

Decreased Anxio depressive sx

Cognitive improvement

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3
Q

5ht2a antagonism

A

Decreased negative sx

Improvement of EPS

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4
Q

5HT2c antagonism

A

Decreased anxiety sx, decreased negative sx, better cognition
BUT hypotension, sedation and increased weight

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5
Q

Alpha 1 antagonism

A 
Orthostatic hypotension 
Dizziness
Reflex tachycardia 
Sedation
Hypersalivation 
Incontienece 
PRIAPISM
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6
Q

Alpha 2 antagonism

A

Sexual dysfunction

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7
Q

Alpha 2 agonism

A

Improved cognitive function

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8
Q

Histamine H1 antagonism

A

Anti emetic

BUT Sedation, weight gain and orthostatic hypotension

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9
Q

M1 antagonism

A 
Decreased EPS
Dry mouth 
Blurry vision 
Constipation
Sinus Tachycardia *
Changes in QRS
Memory problems 
Sedation
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10
Q

Medication contraindicated with clozapine

A

Carbamazepine

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11
Q

Medication other than clozapine that can give agranulocytosis

A

Carbamazepine

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12
Q

Green light clozapine

A

WBC >3.5

ANC >2.0

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13
Q

Yellow light clozapine

A

WBC 3-3.5
ANC 1.5-2

CBC 2x per week until green
Keep taking clozapine, take vital signs

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14
Q

Red light clozapine

A

WBC <3
ANC <1.5

Redo CBC in 24 hrs if continues STOP
CBC once a week for a month
Contact hematology

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15
Q

Carbamazepine side effects

A 
Decreased T3 and T4
SIADH
agranulocytosis 
Can give sjs, ten
Ataxia, sedation, GI
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16
Q

Lurasidone

A

Metabolized 3A4
Start 40 mg ad 160
Need to take with 350 cal
Weight neutral, no etc problem

17
Q

Ziprasidone

A 
80-160mg 
But more efficacious >120 mg
Has antihistaminic properties, blocks H1
Take with 500cal
No weight gain
18
Q

GABA A

A

Rapid

19
Q

GABA B

A

Slow

20
Q

Glutamate

A

Fast action

Precursor of GABA

21
Q

Renal failure extends the half life of

A

Venlafaxine
Paroxetine
Mirtazapine
Buproprion

22
Q

Mirtazapine mechanism of action

A

Alpha 1 antagonist
5HT2 and 3 antagonist
H1 and muscarinic antagonist

Dafna's Flashcards (8 decks)

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