Pharmacology Flashcards
1
Q
What is the MOA of Esomeprazole?
A
Irreversible PPI - blocks gastric H K ATPase = reduced acid uptake
2
Q
What are the ADR’s of Esomeprazole?
A
Abd. pain, GI disturbances, Nausea, Vomiting, Headache
3
Q
What are the CI’s of Esomeprazole?
A
Osteoporosis, C.diff infection, Masks gastric cancer symptoms
4
Q
What is the MOA of Ranitidine?
A
Competitive (reversible) H2 receptor antagonist
5
Q
What are the ADR’s of Ranitidine?
A
Diarrhoea, Dizziness, Headache
6
Q
What are the CI’s of Ranitidine?
A
Masks symptoms of gastric cancers
7
Q
What is the MOA of Rennies (antacids)?
A
Mg & Ca carbonates = strongly alkaline in solution
8
Q
What are the ADR’s of Rennies?
A
Burps as CO2 liberation when acid neutralised by alkali, Diarrhoea
9
Q
What are the CI’s of Rennies?
A
Hypophosphatemic, Renaly impaired, Hepatic Coma
