Pharmacology Flashcards
What is the MOA of Paracetamol?
Reversible inhibitor PGHS peroxidase domain
What are the ADR’s of Paracetamol?
Overdose related Liver toxicity (n-acetyl cysteine)
What are the CI’s of Paracetamol?
Liver failure + acute alcohol toxicity
What is the MOA of Ibuprofen?
NSAID - competitive inhibitor of PGHS cyclo-oxygenase domain
What are the ADR’s of Ibuprofen?
If given IV
Neonatal haemorrhage due to thrombocytopenia
What are the CI’s of Ibuprofen?
History gastric bleeding, impaired renal function
What is the MOA of Codiene
Opioid receptor agonist
What are the ADR’s of Codiene?
Constipation, dizziness, drowsiness, dependence
What are the CI’s of Codiene?
Acute resp. depression, coma
What is the MOA of Prednisolone?
Glucocorticoid steroid receptor agonist
What are the ADR’s of Prednisolone?
Cushings, immune suppresion
What are the CI’s of Prednisolone?
Active infection present
