Pharmacology

Question 1

What is the MOA of Paracetamol?

Answer 1

Reversible inhibitor of PGHS peroxidase domain - PG’s normally sensitise pain responses

Question 2

What is the MOA of Ibuprofen?

Answer 2

NSAID - competitive inhibitor of PGHS cycle-oxygenase domain

Question 3

What is the MOA of Cetirizine?

Answer 3

H1 receptor antagonist - surppresses hyper sensitised immune responses to allergens

Question 4

What is the MOA of Ranitidine?

Answer 4

H2 receptor antagonist - blocks acid secretion from gastric parietal cells

Question 5

Paracetamol ADR’s

Answer 5

over-dose related hepatotoxicity -> treat with infusion of n-acetyl cysteine to restore hepatic reserves of glutathione

Question 6

Paracetamol contraindications

Answer 6

If already in liver failure or acute alcohol toxicity

Question 7

Ibuprofen ADR’s

Answer 7

• Predisposes to GI ulceration + renal dysfunction

- Risk of haemorrhage if given IV from anti-platelet effects

Question 8

Ibuprofen contraindications

Answer 8

History of GI bleeds or chronic kidney disease (CKD)

Question 9

Cetirizine ADR’s

Answer 9

Fatigue
Dizziness
Headache

Question 10

Cetirizine contraindications

Answer 10

If epileptic

Question 11

Ranitidine ADR’s

Answer 11

Diarrhoea
Dizziness
Headache

Question 12

Ranitidine contraindications

Answer 12

May mask gastric malignancies