Pharmacology Flashcards
Agonists
Epi, NE, Clonadine
Epi action
A1: constrict
B1: Iono, chrono, dromo
B2: dilate
Epi Therapy
Broncospasm and vasoconstriction with local anesthetic
Epi pharmacokinetics
rapid
quickly degraded
IM or IV (faster)
Epi adverse effects
CNS: fear, anxiety, tension, tremor, arrhythmia
Antagonist to Insulin
NE action
A1: constricts -> inc Bp -> vagal response -> reflex bradycardia (M2)
NE Therapy
shock
NE Adverse Effects
Anxiety, fear, tremor, skin problem
Clonadine Action
A2: decreases sympathetic outflow from CNS
Clonadine Therapy
withdrawal
HBP
Antagonists (sympatholytics, blockers)
Prazosin
propranolol
Prazosin Action
A1: equilibrium antagonist
Decrease TPR w/o affecting CO
Prazosin Therapy
HBP
benign prostatic hyperplasia
Prazosin Adverse Effects
1st dose: orthostat hypotension
sexual dysfunction
antihypertension side effects with sildenafil or nitrates
Propranolol Action
B1: blocker (SA & AV)
decreases CO
bradycardia
Decreases TPR with prolong use
Propranolol Therapy
HBP
Propranolol Adverse Effects
Broncoconstriction
CNS depression, dizziness, fatigue, short term memory loss
Anticoagulant
Rivaroxaban (xarelto)
Rivaroxaban action
Factor Xa inhibitor
Rivaroxaban Therapy
prevents DVT folllowing hip or knee surgery
Rivaroxaban Adverse Effects
Bleeding
anesthesia or spinal puncture
Rivaroxaban Anitdote
recombinant Factor Xa reverses life threatening bleeding
Antiplatelet
Abciximab
Abciximab (ReoPro) Action
Ab binds to glycoprotein to stop cross linking that form fibrin mesh and prevents platelet aggregation
