Pharmacology Flashcards

1
Q

Agonists

A

Epi, NE, Clonadine

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2
Q

Epi action

A

A1: constrict
B1: Iono, chrono, dromo
B2: dilate

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3
Q

Epi Therapy

A

Broncospasm and vasoconstriction with local anesthetic

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4
Q

Epi pharmacokinetics

A

rapid
quickly degraded
IM or IV (faster)

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5
Q

Epi adverse effects

A

CNS: fear, anxiety, tension, tremor, arrhythmia

Antagonist to Insulin

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6
Q

NE action

A

A1: constricts -> inc Bp -> vagal response -> reflex bradycardia (M2)

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7
Q

NE Therapy

A

shock

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8
Q

NE Adverse Effects

A

Anxiety, fear, tremor, skin problem

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9
Q

Clonadine Action

A

A2: decreases sympathetic outflow from CNS

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10
Q

Clonadine Therapy

A

withdrawal

HBP

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11
Q

Antagonists (sympatholytics, blockers)

A

Prazosin

propranolol

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12
Q

Prazosin Action

A

A1: equilibrium antagonist

Decrease TPR w/o affecting CO

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13
Q

Prazosin Therapy

A

HBP

benign prostatic hyperplasia

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14
Q

Prazosin Adverse Effects

A

1st dose: orthostat hypotension
sexual dysfunction
antihypertension side effects with sildenafil or nitrates

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15
Q

Propranolol Action

A

B1: blocker (SA & AV)
decreases CO
bradycardia
Decreases TPR with prolong use

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16
Q

Propranolol Therapy

A

HBP

17
Q

Propranolol Adverse Effects

A

Broncoconstriction

CNS depression, dizziness, fatigue, short term memory loss

18
Q

Anticoagulant

A

Rivaroxaban (xarelto)

19
Q

Rivaroxaban action

A

Factor Xa inhibitor

20
Q

Rivaroxaban Therapy

A

prevents DVT folllowing hip or knee surgery

21
Q

Rivaroxaban Adverse Effects

A

Bleeding

anesthesia or spinal puncture

22
Q

Rivaroxaban Anitdote

A

recombinant Factor Xa reverses life threatening bleeding

23
Q

Antiplatelet

A

Abciximab

24
Q

Abciximab (ReoPro) Action

A

Ab binds to glycoprotein to stop cross linking that form fibrin mesh and prevents platelet aggregation

25
Q

Abciximab Therapy

A

Acute coronary syndrome

26
Q

Abciximab Adverse Effects

A

Bleeding