Pharmacology

Question 1

HLA subtypes predicting drug reaction

Answer 1

Abacavir – HLA-B57:01 hypersensitivity reaction
Allopurinol – HLA-B58:01 SJS/TEN
Carbamazepine, lamotrigine, oxcarbazepine – HLA-B15:02 SJS/TEN
Carbamazepine HLA-A31:01 SCAR
Flucloxacillin HLA-B57:01 DILI
Dapsone HLA-B13:01 SCAR
Vancomycin HLA-A32:01 DRESS

Question 2

Opioid Conversion - PO and S/C

Answer 2

PO morphine - x1 - 10mg
PO oxycodone - x1.5 - 6.67mg
PO hydromorphone - x5 - 2mg
PO codeine - /8 - 80mg 
PO tapentadol -  /3 - 30mg
PO tramadol - /5 - 50mg
S/C morphine - x3 - 3.33mg
S/C hydromorphone - x15 - 0.67mg
S/C fentanyl - x200 - 0.05mg
S/L buprenorphine - x40 - 0.25mg
TD buprenorphine - x2 - 5mcg/hr
TD fentanyl - x3 - 3.33mcg/hr