Pharmacology

Question 1

Onset of action of antacids?

Answer 1

minutes

Question 2

Antacids ADR?

Answer 2

metabolic alkalosis

Question 3

MoA of Cimetidine?

Answer 3

1. competitive antagonist of H2 receptors on parietal cells

2. inhibits production of cAMP

Question 4

Cimetidine ADR?

Answer 4

• blocks androgen receptor causing male impotency and gynecomastia
• headache
• inhibits Cyt P-450
• galactorrhea (women)

Question 5

Cimetidine problems with increasing dose with long term use?

Answer 5

causes up regulation of H2 receptors and enhanced block of androgen receptors

Question 6

PPI MoA (-prazoles)?

Answer 6

Irreversible inhibit H/K ATPase on parietal cells

-most effective reducers of HCl

Question 7

Uses for PPI?

Answer 7

• ZE syndrome
• ulcers
• GERD

Question 8

PPI ADR?

Answer 8

• Hypergastrin

- ECL and colonic hyperplasia

Question 9

Best use for H. pylori, PPI or H2?

Answer 9

PPI

Question 10

Sucralfate (Carafate) MoA?

Answer 10

Interacts with HCl to form viscous paste that binds to proteins in ulcers to promote direct healing (belly jelly)

Question 11

Sucralfate (carafate) drug interactions?

Answer 11

Do not administer with antacids, H2 blocker, PPI b/c it may bind to them
-administer 2 hours prior to sucralfate

Question 12

Misoprostol MoA?

Answer 12

PGE1 analog that increases mucous

Question 13

Bismuth use?

Answer 13

bactericidal to H. pylori

Question 14

Triple therapy for H. pylori?

Answer 14

1. PPI
2. Clarithromycin
3. Amoxicillin or Metronidazole

Question 15

Treatment of GERD?

Answer 15

PPI