Pharmacology Flashcards
å1
Vascular smooth muscle - contraction
Pupillary dilator muscle - contraction (dilates pupil)
Prostate - contraction
Heart - increases force of contraction
å2
Postsynaptic CNS neurons - multiple
Platelets - aggregation
Adrenergic and cholinergic nerve terminals - inhibits transmitter release
Some vascular smooth muscle - contraction
Fat cells - inhibits lipolysis
ß1
Heart, JG cells - increase force and rate of contraction ad increases renin release
ß2
Respiratory, uterine and vascular smooth muscle - promotes smooth muscle relaxation
Skeletal muscle - promotes K+ uptake
Human liver - Activates glycogenolysis and gluconeogenesis
ß3
Bladder - relaxes detrusor muscle
Fat cells - activates lipolysis
D1
Smooth muscle - Dilates renal blood vessels
D2
Nerve endings - modulates transmitter release
Direct-acting Cholinomimetics
Acetylcholine Bethanechol Carbachol Cevimeline Methacholine Pilocarpine Varenicline (Chantix) - only used for smoking cessation
Cholinesterase inhibitors
Ambenonium Donepezil Echothiophate Edrophonium Galantamine Neostigmine Physostigmine Pyridostigmine Rivastigmine Tacrine
A.) Cholinesterase regenerator
A.) Pralidoxime,
Ganglion Blockers
Mecamylamine
Antimuscarinic Drugs A.) Drugs used for motion sickness B.) Drugs for GI DO C.) Drugs used in ophthalmology D.) Drugs used for respiratory DO E.) Drugs used for Urinary DO F.) Drugs used for cholinergic poisoning G.) Drugs used for movement DO
A.) Scopolamine
B.) Atropine, Dicyclomine, Glucopyrrolate, Hyoscyamine
C.) Atropine, Cyclopentolate, Homatropine, Scopolamine, Tropicamide
D.) Ipratropium, Tiotropium
E.) Darifenacin, Fesoterodine, Oxybutynin, Solifenacin, Tolterodine, Trospium
F.) Atropine + pralidoxime
G.) Benzotropine, Biperiden, Orphenadrine, Procyclidine, Trihexyphenidyl
Direct Acting Adrenomimetics A.) å agonists B.) Mixed Alpha and beta agonists C.) ß agonists D.) Dopamine agonists
A.) Phenylephrine å1, Clonidine å2
B.) NE and E
C.) Dobutamine ß1, Isoproterenol, Albuterol
D.) Dopamine
Indirect Adrenomimetics
A.) Inhibits re-uptake of DA and NE
B.) Inhibitors of MOA
C.) Reverse NE and DA uptake mechanisms and their release
D.) Releasing agent And Direct adrenergic receptor agonist
A.) cocaine
B.) Selegiline, Phenelzine
C.) Amphetamines, Methylphenidate, Tyramine
D.) Ephedrine
Direct Acting antiadrenergic drugs
A.) å adrenoceptor antagonists - Non-selective
B.) å adrenoceptor antagonists - å1 receptor
C.) Mixed Blockers
D.) ß adrenoceptor blockers - ß1 and ß2
E.) ß adrenoceptor blockers - ß1 selective
A.) Phentolamine, Phenoxybenzamine B.) Prazosin, Tamsulosin, Doxazosin C.) Labetalol, Carvedilol D.) Propranolol, Pindolol, Nadolol E.) Metoprolol, Betaxolol, Acebutolol, Atenolol
