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BOARD EXAM > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Branch of medicine concerned with USE, EFFECTS, and MODES OF ACTION of drugs

A

Pharmacology

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2
Q

Concerned with EFFECT OF DRUGS and MECHANISM OF ACTION

A

Pharmacodynamics

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3
Q

Concerned with MOVEMENT of drugs

A

Pharmacokinetics

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4
Q

Movement of Drugs

A

Absorption
Distribution
Metabolism
Excretion

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5
Q

Water Soluble Vitamins

A

Vit B

Vit C

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6
Q

Lipid Soluble Vitamins

A 
Vitamin:
A
D
E
K
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7
Q

Study of drug’s HARMFUL effects

A

Toxicology

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8
Q

Example of drugs that reverses toxicity

A

Activated Charcoal

Syrup of Ipecac

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9
Q

Accumulation of drug because it cannot be excreted by the body

A

Cumulation

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10
Q

Drugs CONTRAINDICATED for px with GLAUCOMA

A

Cholinergics
Anti-Cholinergics
Diazepam

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11
Q

Most allergenic drug

A

Penicillins

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12
Q

Study of DAMAGE TO FETUS

A

Teratology

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13
Q

Study of DRUG DOSAGE

A

Posology

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14
Q

Routes for administration of drugs

A

Enteral
Parenteral
Inhalation

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15
Q

Enteral administration

A

Oral

Rectal

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16
Q

Parenteral administration

A 
Intradermal
Intravenous
Subcutaneous
Intramuscular
Intrathecal
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17
Q

Fastest route of drug administration to reach the brain

A

Inhalation

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18
Q

Intradermal angulation

A

0-15 degrees

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19
Q

Intravenous angulation

A

35 degrees

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20
Q

Subcutaneous angulation

A

45 degrees

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21
Q

Intramuscular angulation

A

90 degrees

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22
Q

Drug properties that influence absorption

A

Weak acid

Weak base

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23
Q

Amount of drug that reaches the systemic circulation

A

Bioavailability

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24
Q

Common site for Intravenous Medications

A

Antecubital Region

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25
Q

Common sites for intramuscular administration

A

Pedia - Vastus lateralis

Adults - Dorsogluteal

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26
Q

Factors that affect bioavailability of drugs

A

Solubility
Route
First-Pass effect

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27
Q

Phenomenkn where concentration of orally taken drugs is REDUCED before reaching systemic circulation

A

First-Pass Effect

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28
Q

Types of drug according to distribution

A

Free Ionized Drug

Bound Drug

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29
Q

Temporary Storage of Drugs

A

Adipocytes

Blood

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30
Q

Tendency of a substance to separate or dissociate from binding

A

Dissociation Constant

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31
Q

Metabolic Pathways

A

Liver

Plasma

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32
Q

Types of liver enzymes

A

Microsomal

Non-microsomal

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33
Q

Function of liver in metabolism

A

Lipid soluble to lipid insoluble
Active drug to inactive
Prodrug to active

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34
Q

Aspirin is converted to

A

Salicylates

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35
Q

Codein is converted to

A

Morphine

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36
Q

Types of local anesthesia

A

Amide

Esters

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37
Q

Drug of choice if allergic to amide and ester

A

Diphenhydramin Hydrochloride

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38
Q

Amide exception

A

Articaine

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39
Q

Ester excemption

A

Piperocaine

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40
Q

Sites for excretion

A 
Kidney
Lungs
Breast milk
Bile
Large intestine
Saliva
Sweat
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41
Q

Plasma enzyme

A

Plasma pseudocholinesterase

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42
Q

Drugs metabolized in the plasma

A

Ester LA

Succinylcholine

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43
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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44
Q

LA metabolized in the liver

A

Amide

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45
Q

LA metabolized in plasma

A

Esters

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46
Q

Time required for drug to reduce half of its initial value

A

Half life

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47
Q

Rate at which drug is removed from the body

A

Clearance

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48
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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49
Q

Constant clearance, not constant half life

A

Zero order kinetics

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50
Q

Not constant clearance, constant half life

A

First order kinetics

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51
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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52
Q

Dosage of drug needed to produce an effect

A

Potency

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53
Q

Effect of drug

A

Efficacy

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54
Q

How well drug can be used in the real world

A

Effectiveness

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55
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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56
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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57
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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58
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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59
Q

Formula for therapeutic index

A

TI= LD50/ED50

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60
Q

Median effective dose

A

ED50

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61
Q

Median lethal dose

A

LD50

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62
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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63
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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64
Q

Receptor for pilocarpine

A

Muscarinic

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65
Q

Drug properties

A

Affinity

Intrinsic activity

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66
Q

Ability of drug to bind to target sites

A

Affinity

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67
Q

Ability of drug to produce an effect

A

Intrinsic activity

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68
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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69
Q

Types of antagonist

A

Competitive

Non-competitive

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70
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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71
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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72
Q

Antagonist that results in dec potency

A

Competitive

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73
Q

Antagonist that results in dec efficacy

A

Non competitive

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74
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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75
Q

Antagonist of benzodiazepines

A

Flumazenil

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76
Q

Acts as agonist and antagonist

A

Partial agonist

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77
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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78
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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79
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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80
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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81
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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82
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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83
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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84
Q

LA metabolized in the liver

A

Amide

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85
Q

LA metabolized in plasma

A

Esters

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86
Q

Time required for drug to reduce half of its initial value

A

Half life

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87
Q

Rate at which drug is removed from the body

A

Clearance

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88
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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89
Q

Constant clearance, not constant half life

A

Zero order kinetics

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90
Q

Not constant clearance, constant half life

A

First order kinetics

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91
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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92
Q

Dosage of drug needed to produce an effect

A

Potency

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93
Q

Effect of drug

A

Efficacy

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94
Q

How well drug can be used in the real world

A

Effectiveness

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95
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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96
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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97
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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98
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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99
Q

Formula for therapeutic index

A

TI= LD50/ED50

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100
Q

Median effective dose

A

ED50

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101
Q

Median lethal dose

A

LD50

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102
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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103
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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104
Q

Receptor for pilocarpine

A

Muscarinic

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105
Q

Drug properties

A

Affinity

Intrinsic activity

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106
Q

Ability of drug to bind to target sites

A

Affinity

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107
Q

Ability of drug to produce an effect

A

Intrinsic activity

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108
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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109
Q

Types of antagonist

A

Competitive

Non-competitive

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110
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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111
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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112
Q

Antagonist that results in dec potency

A

Competitive

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113
Q

Antagonist that results in dec efficacy

A

Non competitive

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114
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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115
Q

Antagonist of benzodiazepines

A

Flumazenil

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116
Q

Acts as agonist and antagonist

A

Partial agonist

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117
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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118
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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119
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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120
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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121
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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122
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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123
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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124
Q

LA metabolized in the liver

A

Amide

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125
Q

LA metabolized in plasma

A

Esters

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126
Q

Time required for drug to reduce half of its initial value

A

Half life

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127
Q

Rate at which drug is removed from the body

A

Clearance

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128
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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129
Q

Constant clearance, not constant half life

A

Zero order kinetics

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130
Q

Not constant clearance, constant half life

A

First order kinetics

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131
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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132
Q

Dosage of drug needed to produce an effect

A

Potency

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133
Q

Effect of drug

A

Efficacy

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134
Q

How well drug can be used in the real world

A

Effectiveness

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135
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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136
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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137
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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138
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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139
Q

Formula for therapeutic index

A

TI= LD50/ED50

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140
Q

Median effective dose

A

ED50

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141
Q

Median lethal dose

A

LD50

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142
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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143
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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144
Q

Receptor for pilocarpine

A

Muscarinic

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145
Q

Drug properties

A

Affinity

Intrinsic activity

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146
Q

Ability of drug to bind to target sites

A

Affinity

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147
Q

Ability of drug to produce an effect

A

Intrinsic activity

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148
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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149
Q

Types of antagonist

A

Competitive

Non-competitive

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150
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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151
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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152
Q

Antagonist that results in dec potency

A

Competitive

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153
Q

Antagonist that results in dec efficacy

A

Non competitive

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154
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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155
Q

Antagonist of benzodiazepines

A

Flumazenil

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156
Q

Acts as agonist and antagonist

A

Partial agonist

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157
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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158
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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159
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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160
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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161
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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162
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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163
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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164
Q

LA metabolized in the liver

A

Amide

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165
Q

LA metabolized in plasma

A

Esters

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166
Q

Time required for drug to reduce half of its initial value

A

Half life

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167
Q

Rate at which drug is removed from the body

A

Clearance

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168
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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169
Q

Constant clearance, not constant half life

A

Zero order kinetics

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170
Q

Not constant clearance, constant half life

A

First order kinetics

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171
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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172
Q

Dosage of drug needed to produce an effect

A

Potency

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173
Q

Effect of drug

A

Efficacy

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174
Q

How well drug can be used in the real world

A

Effectiveness

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175
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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176
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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177
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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178
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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179
Q

Formula for therapeutic index

A

TI= LD50/ED50

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180
Q

Median effective dose

A

ED50

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181
Q

Median lethal dose

A

LD50

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182
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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183
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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184
Q

Receptor for pilocarpine

A

Muscarinic

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185
Q

Drug properties

A

Affinity

Intrinsic activity

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186
Q

Ability of drug to bind to target sites

A

Affinity

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187
Q

Ability of drug to produce an effect

A

Intrinsic activity

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188
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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189
Q

Types of antagonist

A

Competitive

Non-competitive

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190
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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191
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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192
Q

Antagonist that results in dec potency

A

Competitive

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193
Q

Antagonist that results in dec efficacy

A

Non competitive

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194
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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195
Q

Antagonist of benzodiazepines

A

Flumazenil

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196
Q

Acts as agonist and antagonist

A

Partial agonist

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197
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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198
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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199
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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200
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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201
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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202
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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203
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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204
Q

LA metabolized in the liver

A

Amide

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205
Q

LA metabolized in plasma

A

Esters

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206
Q

Time required for drug to reduce half of its initial value

A

Half life

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207
Q

Rate at which drug is removed from the body

A

Clearance

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208
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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209
Q

Constant clearance, not constant half life

A

Zero order kinetics

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210
Q

Not constant clearance, constant half life

A

First order kinetics

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211
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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212
Q

Dosage of drug needed to produce an effect

A

Potency

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213
Q

Effect of drug

A

Efficacy

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214
Q

How well drug can be used in the real world

A

Effectiveness

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215
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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216
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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217
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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218
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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219
Q

Formula for therapeutic index

A

TI= LD50/ED50

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220
Q

Median effective dose

A

ED50

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221
Q

Median lethal dose

A

LD50

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222
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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223
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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224
Q

Receptor for pilocarpine

A

Muscarinic

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225
Q

Drug properties

A

Affinity

Intrinsic activity

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226
Q

Ability of drug to bind to target sites

A

Affinity

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227
Q

Ability of drug to produce an effect

A

Intrinsic activity

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228
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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229
Q

Types of antagonist

A

Competitive

Non-competitive

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230
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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231
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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232
Q

Antagonist that results in dec potency

A

Competitive

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233
Q

Antagonist that results in dec efficacy

A

Non competitive

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234
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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235
Q

Antagonist of benzodiazepines

A

Flumazenil

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236
Q

Acts as agonist and antagonist

A

Partial agonist

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237
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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238
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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239
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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240
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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241
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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242
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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243
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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244
Q

LA metabolized in the liver

A

Amide

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245
Q

LA metabolized in plasma

A

Esters

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246
Q

Time required for drug to reduce half of its initial value

A

Half life

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247
Q

Rate at which drug is removed from the body

A

Clearance

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248
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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249
Q

Constant clearance, not constant half life

A

Zero order kinetics

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250
Q

Not constant clearance, constant half life

A

First order kinetics

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251
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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252
Q

Dosage of drug needed to produce an effect

A

Potency

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253
Q

Effect of drug

A

Efficacy

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254
Q

How well drug can be used in the real world

A

Effectiveness

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255
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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256
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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257
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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258
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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259
Q

Formula for therapeutic index

A

TI= LD50/ED50

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260
Q

Median effective dose

A

ED50

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261
Q

Median lethal dose

A

LD50

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262
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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263
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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264
Q

Receptor for pilocarpine

A

Muscarinic

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265
Q

Drug properties

A

Affinity

Intrinsic activity

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266
Q

Ability of drug to bind to target sites

A

Affinity

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267
Q

Ability of drug to produce an effect

A

Intrinsic activity

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268
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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269
Q

Types of antagonist

A

Competitive

Non-competitive

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270
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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271
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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272
Q

Antagonist that results in dec potency

A

Competitive

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273
Q

Antagonist that results in dec efficacy

A

Non competitive

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274
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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275
Q

Antagonist of benzodiazepines

A

Flumazenil

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276
Q

Acts as agonist and antagonist

A

Partial agonist

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277
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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278
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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279
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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280
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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281
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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282
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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283
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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284
Q

LA metabolized in the liver

A

Amide

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285
Q

LA metabolized in plasma

A

Esters

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286
Q

Time required for drug to reduce half of its initial value

A

Half life

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287
Q

Rate at which drug is removed from the body

A

Clearance

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288
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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289
Q

Constant clearance, not constant half life

A

Zero order kinetics

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290
Q

Not constant clearance, constant half life

A

First order kinetics

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291
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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292
Q

Dosage of drug needed to produce an effect

A

Potency

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293
Q

Effect of drug

A

Efficacy

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294
Q

How well drug can be used in the real world

A

Effectiveness

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295
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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296
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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297
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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298
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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299
Q

Formula for therapeutic index

A

TI= LD50/ED50

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300
Q

Median effective dose

A

ED50

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301
Q

Median lethal dose

A

LD50

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302
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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303
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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304
Q

Receptor for pilocarpine

A

Muscarinic

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305
Q

Drug properties

A

Affinity

Intrinsic activity

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306
Q

Ability of drug to bind to target sites

A

Affinity

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307
Q

Ability of drug to produce an effect

A

Intrinsic activity

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308
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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309
Q

Types of antagonist

A

Competitive

Non-competitive

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310
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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311
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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312
Q

Antagonist that results in dec potency

A

Competitive

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313
Q

Antagonist that results in dec efficacy

A

Non competitive

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314
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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315
Q

Antagonist of benzodiazepines

A

Flumazenil

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316
Q

Acts as agonist and antagonist

A

Partial agonist

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317
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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318
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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319
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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320
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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321
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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322
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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323
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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324
Q

LA metabolized in the liver

A

Amide

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325
Q

LA metabolized in plasma

A

Esters

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326
Q

Time required for drug to reduce half of its initial value

A

Half life

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327
Q

Rate at which drug is removed from the body

A

Clearance

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328
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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329
Q

Constant clearance, not constant half life

A

Zero order kinetics

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330
Q

Not constant clearance, constant half life

A

First order kinetics

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331
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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332
Q

Dosage of drug needed to produce an effect

A

Potency

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333
Q

Effect of drug

A

Efficacy

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334
Q

How well drug can be used in the real world

A

Effectiveness

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335
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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336
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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337
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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338
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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339
Q

Formula for therapeutic index

A

TI= LD50/ED50

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340
Q

Median effective dose

A

ED50

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341
Q

Median lethal dose

A

LD50

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342
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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343
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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344
Q

Receptor for pilocarpine

A

Muscarinic

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345
Q

Drug properties

A

Affinity

Intrinsic activity

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346
Q

Ability of drug to bind to target sites

A

Affinity

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347
Q

Ability of drug to produce an effect

A

Intrinsic activity

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348
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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349
Q

Types of antagonist

A

Competitive

Non-competitive

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350
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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351
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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352
Q

Antagonist that results in dec potency

A

Competitive

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353
Q

Antagonist that results in dec efficacy

A

Non competitive

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354
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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355
Q

Antagonist of benzodiazepines

A

Flumazenil

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356
Q

Acts as agonist and antagonist

A

Partial agonist

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357
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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358
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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359
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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360
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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361
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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362
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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363
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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364
Q

LA metabolized in the liver

A

Amide

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365
Q

LA metabolized in plasma

A

Esters

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366
Q

Time required for drug to reduce half of its initial value

A

Half life

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367
Q

Rate at which drug is removed from the body

A

Clearance

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368
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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369
Q

Constant clearance, not constant half life

A

Zero order kinetics

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370
Q

Not constant clearance, constant half life

A

First order kinetics

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371
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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372
Q

Dosage of drug needed to produce an effect

A

Potency

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373
Q

Effect of drug

A

Efficacy

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374
Q

How well drug can be used in the real world

A

Effectiveness

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375
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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376
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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377
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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378
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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379
Q

Formula for therapeutic index

A

TI= LD50/ED50

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380
Q

Median effective dose

A

ED50

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381
Q

Median lethal dose

A

LD50

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382
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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383
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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384
Q

Receptor for pilocarpine

A

Muscarinic

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385
Q

Drug properties

A

Affinity

Intrinsic activity

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386
Q

Ability of drug to bind to target sites

A

Affinity

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387
Q

Ability of drug to produce an effect

A

Intrinsic activity

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388
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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389
Q

Types of antagonist

A

Competitive

Non-competitive

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390
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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391
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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392
Q

Antagonist that results in dec potency

A

Competitive

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393
Q

Antagonist that results in dec efficacy

A

Non competitive

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394
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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395
Q

Antagonist of benzodiazepines

A

Flumazenil

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396
Q

Acts as agonist and antagonist

A

Partial agonist

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397
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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398
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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399
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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400
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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401
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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402
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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403
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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404
Q

LA metabolized in the liver

A

Amide

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405
Q

LA metabolized in plasma

A

Esters

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406
Q

Time required for drug to reduce half of its initial value

A

Half life

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407
Q

Rate at which drug is removed from the body

A

Clearance

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408
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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409
Q

Constant clearance, not constant half life

A

Zero order kinetics

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410
Q

Not constant clearance, constant half life

A

First order kinetics

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411
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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412
Q

Dosage of drug needed to produce an effect

A

Potency

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413
Q

Effect of drug

A

Efficacy

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414
Q

How well drug can be used in the real world

A

Effectiveness

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415
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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416
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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417
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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418
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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419
Q

Formula for therapeutic index

A

TI= LD50/ED50

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420
Q

Median effective dose

A

ED50

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421
Q

Median lethal dose

A

LD50

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422
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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423
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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424
Q

Receptor for pilocarpine

A

Muscarinic

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425
Q

Drug properties

A

Affinity

Intrinsic activity

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426
Q

Ability of drug to bind to target sites

A

Affinity

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427
Q

Ability of drug to produce an effect

A

Intrinsic activity

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428
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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429
Q

Types of antagonist

A

Competitive

Non-competitive

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430
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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431
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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432
Q

Antagonist that results in dec potency

A

Competitive

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433
Q

Antagonist that results in dec efficacy

A

Non competitive

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434
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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435
Q

Antagonist of benzodiazepines

A

Flumazenil

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436
Q

Acts as agonist and antagonist

A

Partial agonist

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437
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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438
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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439
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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440
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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441
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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442
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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443
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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444
Q

LA metabolized in the liver

A

Amide

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445
Q

LA metabolized in plasma

A

Esters

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446
Q

Time required for drug to reduce half of its initial value

A

Half life

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447
Q

Rate at which drug is removed from the body

A

Clearance

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448
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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449
Q

Constant clearance, not constant half life

A

Zero order kinetics

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450
Q

Not constant clearance, constant half life

A

First order kinetics

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451
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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452
Q

Dosage of drug needed to produce an effect

A

Potency

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453
Q

Effect of drug

A

Efficacy

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454
Q

How well drug can be used in the real world

A

Effectiveness

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455
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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456
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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457
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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458
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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459
Q

Formula for therapeutic index

A

TI= LD50/ED50

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460
Q

Median effective dose

A

ED50

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461
Q

Median lethal dose

A

LD50

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462
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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463
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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464
Q

Receptor for pilocarpine

A

Muscarinic

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465
Q

Drug properties

A

Affinity

Intrinsic activity

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466
Q

Ability of drug to bind to target sites

A

Affinity

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467
Q

Ability of drug to produce an effect

A

Intrinsic activity

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468
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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469
Q

Types of antagonist

A

Competitive

Non-competitive

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470
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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471
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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472
Q

Antagonist that results in dec potency

A

Competitive

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473
Q

Antagonist that results in dec efficacy

A

Non competitive

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474
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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475
Q

Antagonist of benzodiazepines

A

Flumazenil

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476
Q

Acts as agonist and antagonist

A

Partial agonist

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477
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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478
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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479
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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480
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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481
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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482
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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483
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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484
Q

LA metabolized in the liver

A

Amide

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485
Q

LA metabolized in plasma

A

Esters

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486
Q

Time required for drug to reduce half of its initial value

A

Half life

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487
Q

Rate at which drug is removed from the body

A

Clearance

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488
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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489
Q

Constant clearance, not constant half life

A

Zero order kinetics

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490
Q

Not constant clearance, constant half life

A

First order kinetics

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491
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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492
Q

Dosage of drug needed to produce an effect

A

Potency

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493
Q

Effect of drug

A

Efficacy

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494
Q

How well drug can be used in the real world

A

Effectiveness

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495
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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496
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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497
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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498
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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499
Q

Formula for therapeutic index

A

TI= LD50/ED50

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500
Q

Median effective dose

A

ED50

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501
Q

Median lethal dose

A

LD50

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502
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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503
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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504
Q

Receptor for pilocarpine

A

Muscarinic

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505
Q

Drug properties

A

Affinity

Intrinsic activity

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506
Q

Ability of drug to bind to target sites

A

Affinity

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507
Q

Ability of drug to produce an effect

A

Intrinsic activity

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508
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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509
Q

Types of antagonist

A

Competitive

Non-competitive

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510
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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511
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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512
Q

Antagonist that results in dec potency

A

Competitive

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513
Q

Antagonist that results in dec efficacy

A

Non competitive

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514
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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515
Q

Antagonist of benzodiazepines

A

Flumazenil

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516
Q

Acts as agonist and antagonist

A

Partial agonist

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517
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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518
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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519
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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520
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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521
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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522
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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523
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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524
Q

LA metabolized in the liver

A

Amide

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525
Q

LA metabolized in plasma

A

Esters

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526
Q

Time required for drug to reduce half of its initial value

A

Half life

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527
Q

Rate at which drug is removed from the body

A

Clearance

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528
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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529
Q

Constant clearance, not constant half life

A

Zero order kinetics

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530
Q

Not constant clearance, constant half life

A

First order kinetics

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531
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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532
Q

Dosage of drug needed to produce an effect

A

Potency

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533
Q

Effect of drug

A

Efficacy

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534
Q

How well drug can be used in the real world

A

Effectiveness

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535
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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536
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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537
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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538
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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539
Q

Formula for therapeutic index

A

TI= LD50/ED50

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540
Q

Median effective dose

A

ED50

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541
Q

Median lethal dose

A

LD50

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542
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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543
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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544
Q

Receptor for pilocarpine

A

Muscarinic

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545
Q

Drug properties

A

Affinity

Intrinsic activity

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546
Q

Ability of drug to bind to target sites

A

Affinity

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547
Q

Ability of drug to produce an effect

A

Intrinsic activity

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548
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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549
Q

Types of antagonist

A

Competitive

Non-competitive

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550
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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551
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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552
Q

Antagonist that results in dec potency

A

Competitive

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553
Q

Antagonist that results in dec efficacy

A

Non competitive

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554
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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555
Q

Antagonist of benzodiazepines

A

Flumazenil

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556
Q

Acts as agonist and antagonist

A

Partial agonist

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557
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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558
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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559
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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560
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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561
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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562
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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563
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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564
Q

LA metabolized in the liver

A

Amide

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565
Q

LA metabolized in plasma

A

Esters

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566
Q

Time required for drug to reduce half of its initial value

A

Half life

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567
Q

Rate at which drug is removed from the body

A

Clearance

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568
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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569
Q

Constant clearance, not constant half life

A

Zero order kinetics

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570
Q

Not constant clearance, constant half life

A

First order kinetics

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571
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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572
Q

Dosage of drug needed to produce an effect

A

Potency

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573
Q

Effect of drug

A

Efficacy

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574
Q

How well drug can be used in the real world

A

Effectiveness

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575
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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576
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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577
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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578
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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579
Q

Formula for therapeutic index

A

TI= LD50/ED50

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580
Q

Median effective dose

A

ED50

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581
Q

Median lethal dose

A

LD50

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582
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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583
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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584
Q

Receptor for pilocarpine

A

Muscarinic

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585
Q

Drug properties

A

Affinity

Intrinsic activity

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586
Q

Ability of drug to bind to target sites

A

Affinity

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587
Q

Ability of drug to produce an effect

A

Intrinsic activity

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588
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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589
Q

Types of antagonist

A

Competitive

Non-competitive

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590
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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591
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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592
Q

Antagonist that results in dec potency

A

Competitive

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593
Q

Antagonist that results in dec efficacy

A

Non competitive

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594
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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595
Q

Antagonist of benzodiazepines

A

Flumazenil

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596
Q

Acts as agonist and antagonist

A

Partial agonist

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597
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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598
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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599
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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600
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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601
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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602
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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603
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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604
Q

LA metabolized in the liver

A

Amide

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605
Q

LA metabolized in plasma

A

Esters

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606
Q

Time required for drug to reduce half of its initial value

A

Half life

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607
Q

Rate at which drug is removed from the body

A

Clearance

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608
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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609
Q

Constant clearance, not constant half life

A

Zero order kinetics

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610
Q

Not constant clearance, constant half life

A

First order kinetics

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611
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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612
Q

Dosage of drug needed to produce an effect

A

Potency

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613
Q

Effect of drug

A

Efficacy

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614
Q

How well drug can be used in the real world

A

Effectiveness

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615
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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616
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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617
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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618
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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619
Q

Formula for therapeutic index

A

TI= LD50/ED50

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620
Q

Median effective dose

A

ED50

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621
Q

Median lethal dose

A

LD50

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622
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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623
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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624
Q

Receptor for pilocarpine

A

Muscarinic

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625
Q

Drug properties

A

Affinity

Intrinsic activity

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626
Q

Ability of drug to bind to target sites

A

Affinity

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627
Q

Ability of drug to produce an effect

A

Intrinsic activity

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628
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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629
Q

Types of antagonist

A

Competitive

Non-competitive

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630
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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631
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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632
Q

Antagonist that results in dec potency

A

Competitive

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633
Q

Antagonist that results in dec efficacy

A

Non competitive

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634
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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635
Q

Antagonist of benzodiazepines

A

Flumazenil

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636
Q

Acts as agonist and antagonist

A

Partial agonist

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637
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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638
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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639
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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640
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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641
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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642
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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643
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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644
Q

LA metabolized in the liver

A

Amide

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645
Q

LA metabolized in plasma

A

Esters

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646
Q

Time required for drug to reduce half of its initial value

A

Half life

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647
Q

Rate at which drug is removed from the body

A

Clearance

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648
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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649
Q

Constant clearance, not constant half life

A

Zero order kinetics

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650
Q

Not constant clearance, constant half life

A

First order kinetics

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651
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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652
Q

Dosage of drug needed to produce an effect

A

Potency

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653
Q

Effect of drug

A

Efficacy

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654
Q

How well drug can be used in the real world

A

Effectiveness

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655
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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656
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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657
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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658
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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659
Q

Formula for therapeutic index

A

TI= LD50/ED50

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660
Q

Median effective dose

A

ED50

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661
Q

Median lethal dose

A

LD50

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662
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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663
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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664
Q

Receptor for pilocarpine

A

Muscarinic

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665
Q

Drug properties

A

Affinity

Intrinsic activity

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666
Q

Ability of drug to bind to target sites

A

Affinity

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667
Q

Ability of drug to produce an effect

A

Intrinsic activity

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668
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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669
Q

Types of antagonist

A

Competitive

Non-competitive

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670
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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671
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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672
Q

Antagonist that results in dec potency

A

Competitive

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673
Q

Antagonist that results in dec efficacy

A

Non competitive

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674
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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675
Q

Antagonist of benzodiazepines

A

Flumazenil

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676
Q

Acts as agonist and antagonist

A

Partial agonist

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677
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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678
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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679
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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680
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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681
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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682
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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683
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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684
Q

LA metabolized in the liver

A

Amide

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685
Q

LA metabolized in plasma

A

Esters

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686
Q

Time required for drug to reduce half of its initial value

A

Half life

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3
4
5
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687
Q

Rate at which drug is removed from the body

A

Clearance

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688
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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689
Q

Constant clearance, not constant half life

A

Zero order kinetics

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690
Q

Not constant clearance, constant half life

A

First order kinetics

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691
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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692
Q

Dosage of drug needed to produce an effect

A

Potency

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693
Q

Effect of drug

A

Efficacy

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694
Q

How well drug can be used in the real world

A

Effectiveness

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695
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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696
Q

Dose-effect (dose-response) relationship

A

Graded dose effect curve

Quantal dose effect curve

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697
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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698
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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699
Q

Formula for therapeutic index

A

TI= LD50/ED50

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700
Q

Median effective dose

A

ED50

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701
Q

Median lethal dose

A

LD50

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702
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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703
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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704
Q

Receptor for pilocarpine

A

Muscarinic

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705
Q

Drug properties

A

Affinity

Intrinsic activity

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706
Q

Ability of drug to bind to target sites

A

Affinity

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707
Q

Ability of drug to produce an effect

A

Intrinsic activity

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708
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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709
Q

Types of antagonist

A

Competitive

Non-competitive

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710
Q

Antagonist that competes with receptor sites of agonist

A

Competitive

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711
Q

Antagonist that does not compete with agonist and has own receptors

A

Non-competitive

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712
Q

Antagonist that results in dec potency

A

Competitive

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713
Q

Antagonist that results in dec efficacy

A

Non competitive

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714
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

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715
Q

Antagonist of benzodiazepines

A

Flumazenil

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716
Q

Acts as agonist and antagonist

A

Partial agonist

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717
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

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718
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

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719
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

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720
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

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721
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

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722
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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723
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

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724
Q

LA metabolized in the liver

A

Amide

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725
Q

LA metabolized in plasma

A

Esters

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726
Q

Time required for drug to reduce half of its initial value

A

Half life

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727
Q

Rate at which drug is removed from the body

A

Clearance

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728
Q

Types of clearance

A

Zero order kinetics

First order kinetics

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729
Q

Constant clearance, not constant half life

A

Zero order kinetics

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730
Q

Not constant clearance, constant half life

A

First order kinetics

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731
Q

Drug which has more chances of cumulation

A

Zero order kinetics

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732
Q

Dosage of drug needed to produce an effect

A

Potency

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733
Q

Effect of drug

A

Efficacy

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734
Q

How well drug can be used in the real world

A

Effectiveness

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735
Q

Effect of drug are dose dependent

A

Dose-effect relationship

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736
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

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737
Q

Degree of response of a single biological unit

A

Graded dose effect curve

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738
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

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739
Q

Formula for therapeutic index

A

TI= LD50/ED50

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740
Q

Median effective dose

A

ED50

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741
Q

Median lethal dose

A

LD50

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742
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

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743
Q

Receptors for narcotics

A

Mu
Kappa
Delta

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744
Q

Receptor for pilocarpine

A

Muscarinic

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745
Q

Drug properties

A

Affinity

Intrinsic activity

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746
Q

Ability of drug to bind to target sites

A

Affinity

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747
Q

Ability of drug to produce an effect

A

Intrinsic activity

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748
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

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749
Q

Types of antagonist

A

Competitive

Non-competitive

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750
Q

Competes with receptor sites of agonist

A

Competitive

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751
Q

Does not compete with agonist and has own receptors

A

Non-competitive

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752
Q

Results in dec potency

A

Complete

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753
Q

Results in dec efficacy

A

Non competitive

754
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

755
Q

Antagonist of benzodiazepines

A

Flumazenil

756
Q

Acts as agonist and antagonist

A

Partial agonist

757
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

758
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

759
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

760
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

761
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

762
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

763
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

764
Q

LA metabolized in the liver

A

Amide

765
Q

LA metabolized in plasma

A

Esters

766
Q

Time required for drug to reduce half of its initial value

A

Half life

767
Q

Rate at which drug is removed from the body

A

Clearance

768
Q

Types of clearance

A

Zero order kinetics

First order kinetics

769
Q

Constant clearance, not constant half life

A

Zero order kinetics

770
Q

Not constant clearance, constant half life

A

First order kinetics

771
Q

Drug which has more chances of cumulation

A

Zero order kinetics

772
Q

Dosage of drug needed to produce an effect

A

Potency

773
Q

Effect of drug

A

Efficacy

774
Q

How well drug can be used in the real world

A

Effectiveness

775
Q

Effect of drug are dose dependent

A

Dose-effect relationship

776
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

777
Q

Degree of response of a single biological unit

A

Graded dose effect curve

778
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

779
Q

Formula for therapeutic index

A

TI= LD50/ED50

780
Q

Median effective dose

A

ED50

781
Q

Median lethal dose

A

LD50

782
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

783
Q

Receptors for narcotics

A

Mu
Kappa
Delta

784
Q

Receptor for pilocarpine

A

Muscarinic

785
Q

Drug properties

A

Affinity

Intrinsic activity

786
Q

Ability of drug to bind to target sites

A

Affinity

787
Q

Ability of drug to produce an effect

A

Intrinsic activity

788
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

789
Q

Types of antagonist

A

Competitive

Non-competitive

790
Q

Competes with receptor sites of agonist

A

Competitive

791
Q

Does not compete with agonist and has own receptors

A

Non-competitive

792
Q

Results in dec potency

A

Complete

793
Q

Results in dec efficacy

A

Non competitive

794
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

795
Q

Antagonist of benzodiazepines

A

Flumazenil

796
Q

Acts as agonist and antagonist

A

Partial agonist

797
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

798
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

799
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

800
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

801
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

802
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

803
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

804
Q

LA metabolized in the liver

A

Amide

805
Q

LA metabolized in plasma

A

Esters

806
Q

Time required for drug to reduce half of its initial value

A

Half life

807
Q

Rate at which drug is removed from the body

A

Clearance

808
Q

Types of clearance

A

Zero order kinetics

First order kinetics

809
Q

Constant clearance, not constant half life

A

Zero order kinetics

810
Q

Not constant clearance, constant half life

A

First order kinetics

811
Q

Drug which has more chances of cumulation

A

Zero order kinetics

812
Q

Dosage of drug needed to produce an effect

A

Potency

813
Q

Effect of drug

A

Efficacy

814
Q

How well drug can be used in the real world

A

Effectiveness

815
Q

Effect of drug are dose dependent

A

Dose-effect relationship

816
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

817
Q

Degree of response of a single biological unit

A

Graded dose effect curve

818
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

819
Q

Formula for therapeutic index

A

TI= LD50/ED50

820
Q

Median effective dose

A

ED50

821
Q

Median lethal dose

A

LD50

822
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

823
Q

Receptors for narcotics

A

Mu
Kappa
Delta

824
Q

Receptor for pilocarpine

A

Muscarinic

825
Q

Drug properties

A

Affinity

Intrinsic activity

826
Q

Ability of drug to bind to target sites

A

Affinity

827
Q

Ability of drug to produce an effect

A

Intrinsic activity

828
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

829
Q

Types of antagonist

A

Competitive

Non-competitive

830
Q

Competes with receptor sites of agonist

A

Competitive

831
Q

Does not compete with agonist and has own receptors

A

Non-competitive

832
Q

Results in dec potency

A

Complete

833
Q

Results in dec efficacy

A

Non competitive

834
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

835
Q

Antagonist of benzodiazepines

A

Flumazenil

836
Q

Acts as agonist and antagonist

A

Partial agonist

837
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

838
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

839
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

840
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

841
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

842
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

843
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

844
Q

LA metabolized in the liver

A

Amide

845
Q

LA metabolized in plasma

A

Esters

846
Q

Time required for drug to reduce half of its initial value

A

Half life

847
Q

Rate at which drug is removed from the body

A

Clearance

848
Q

Types of clearance

A

Zero order kinetics

First order kinetics

849
Q

Constant clearance, not constant half life

A

Zero order kinetics

850
Q

Not constant clearance, constant half life

A

First order kinetics

851
Q

Drug which has more chances of cumulation

A

Zero order kinetics

852
Q

Dosage of drug needed to produce an effect

A

Potency

853
Q

Effect of drug

A

Efficacy

854
Q

How well drug can be used in the real world

A

Effectiveness

855
Q

Effect of drug are dose dependent

A

Dose-effect relationship

856
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

857
Q

Degree of response of a single biological unit

A

Graded dose effect curve

858
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

859
Q

Formula for therapeutic index

A

TI= LD50/ED50

860
Q

Median effective dose

A

ED50

861
Q

Median lethal dose

A

LD50

862
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

863
Q

Receptors for narcotics

A

Mu
Kappa
Delta

864
Q

Receptor for pilocarpine

A

Muscarinic

865
Q

Drug properties

A

Affinity

Intrinsic activity

866
Q

Ability of drug to bind to target sites

A

Affinity

867
Q

Ability of drug to produce an effect

A

Intrinsic activity

868
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

869
Q

Types of antagonist

A

Competitive

Non-competitive

870
Q

Competes with receptor sites of agonist

A

Competitive

871
Q

Does not compete with agonist and has own receptors

A

Non-competitive

872
Q

Results in dec potency

A

Complete

873
Q

Results in dec efficacy

A

Non competitive

874
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

875
Q

Antagonist of benzodiazepines

A

Flumazenil

876
Q

Acts as agonist and antagonist

A

Partial agonist

877
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

878
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

879
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

880
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

881
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

882
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

883
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

884
Q

LA metabolized in the liver

A

Amide

885
Q

LA metabolized in plasma

A

Esters

886
Q

Time required for drug to reduce half of its initial value

A

Half life

887
Q

Rate at which drug is removed from the body

A

Clearance

888
Q

Types of clearance

A

Zero order kinetics

First order kinetics

889
Q

Constant clearance, not constant half life

A

Zero order kinetics

890
Q

Not constant clearance, constant half life

A

First order kinetics

891
Q

Drug which has more chances of cumulation

A

Zero order kinetics

892
Q

Dosage of drug needed to produce an effect

A

Potency

893
Q

Effect of drug

A

Efficacy

894
Q

How well drug can be used in the real world

A

Effectiveness

895
Q

Effect of drug are dose dependent

A

Dose-effect relationship

896
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

897
Q

Degree of response of a single biological unit

A

Graded dose effect curve

898
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

899
Q

Formula for therapeutic index

A

TI= LD50/ED50

900
Q

Median effective dose

A

ED50

901
Q

Median lethal dose

A

LD50

902
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

903
Q

Receptors for narcotics

A

Mu
Kappa
Delta

904
Q

Receptor for pilocarpine

A

Muscarinic

905
Q

Drug properties

A

Affinity

Intrinsic activity

906
Q

Ability of drug to bind to target sites

A

Affinity

907
Q

Ability of drug to produce an effect

A

Intrinsic activity

908
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

909
Q

Types of antagonist

A

Competitive

Non-competitive

910
Q

Competes with receptor sites of agonist

A

Competitive

911
Q

Does not compete with agonist and has own receptors

A

Non-competitive

912
Q

Results in dec potency

A

Complete

913
Q

Results in dec efficacy

A

Non competitive

914
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

915
Q

Antagonist of benzodiazepines

A

Flumazenil

916
Q

Acts as agonist and antagonist

A

Partial agonist

917
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

918
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

919
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

920
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

921
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

922
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

923
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

924
Q

LA metabolized in the liver

A

Amide

925
Q

LA metabolized in plasma

A

Esters

926
Q

Time required for drug to reduce half of its initial value

A

Half life

927
Q

Rate at which drug is removed from the body

A

Clearance

928
Q

Types of clearance

A

Zero order kinetics

First order kinetics

929
Q

Constant clearance, not constant half life

A

Zero order kinetics

930
Q

Not constant clearance, constant half life

A

First order kinetics

931
Q

Drug which has more chances of cumulation

A

Zero order kinetics

932
Q

Dosage of drug needed to produce an effect

A

Potency

933
Q

Effect of drug

A

Efficacy

934
Q

How well drug can be used in the real world

A

Effectiveness

935
Q

Effect of drug are dose dependent

A

Dose-effect relationship

936
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

937
Q

Degree of response of a single biological unit

A

Graded dose effect curve

938
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

939
Q

Formula for therapeutic index

A

TI= LD50/ED50

940
Q

Median effective dose

A

ED50

941
Q

Median lethal dose

A

LD50

942
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

943
Q

Receptors for narcotics

A

Mu
Kappa
Delta

944
Q

Receptor for pilocarpine

A

Muscarinic

945
Q

Drug properties

A

Affinity

Intrinsic activity

946
Q

Ability of drug to bind to target sites

A

Affinity

947
Q

Ability of drug to produce an effect

A

Intrinsic activity

948
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

949
Q

Types of antagonist

A

Competitive

Non-competitive

950
Q

Competes with receptor sites of agonist

A

Competitive

951
Q

Does not compete with agonist and has own receptors

A

Non-competitive

952
Q

Results in dec potency

A

Complete

953
Q

Results in dec efficacy

A

Non competitive

954
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

955
Q

Antagonist of benzodiazepines

A

Flumazenil

956
Q

Acts as agonist and antagonist

A

Partial agonist

957
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

958
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

959
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

960
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

961
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

962
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

963
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

964
Q

LA metabolized in the liver

A

Amide

965
Q

LA metabolized in plasma

A

Esters

966
Q

Time required for drug to reduce half of its initial value

A

Half life

967
Q

Rate at which drug is removed from the body

A

Clearance

968
Q

Types of clearance

A

Zero order kinetics

First order kinetics

969
Q

Constant clearance, not constant half life

A

Zero order kinetics

970
Q

Not constant clearance, constant half life

A

First order kinetics

971
Q

Drug which has more chances of cumulation

A

Zero order kinetics

972
Q

Dosage of drug needed to produce an effect

A

Potency

973
Q

Effect of drug

A

Efficacy

974
Q

How well drug can be used in the real world

A

Effectiveness

975
Q

Effect of drug are dose dependent

A

Dose-effect relationship

976
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

977
Q

Degree of response of a single biological unit

A

Graded dose effect curve

978
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

979
Q

Formula for therapeutic index

A

TI= LD50/ED50

980
Q

Median effective dose

A

ED50

981
Q

Median lethal dose

A

LD50

982
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

983
Q

Receptors for narcotics

A

Mu
Kappa
Delta

984
Q

Receptor for pilocarpine

A

Muscarinic

985
Q

Drug properties

A

Affinity

Intrinsic activity

986
Q

Ability of drug to bind to target sites

A

Affinity

987
Q

Ability of drug to produce an effect

A

Intrinsic activity

988
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

989
Q

Types of antagonist

A

Competitive

Non-competitive

990
Q

Competes with receptor sites of agonist

A

Competitive

991
Q

Does not compete with agonist and has own receptors

A

Non-competitive

992
Q

Results in dec potency

A

Complete

993
Q

Results in dec efficacy

A

Non competitive

994
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

995
Q

Antagonist of benzodiazepines

A

Flumazenil

996
Q

Acts as agonist and antagonist

A

Partial agonist

997
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

998
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

999
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1000
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1001
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1002
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1003
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1004
Q

LA metabolized in the liver

A

Amide

1005
Q

LA metabolized in plasma

A

Esters

1006
Q

Time required for drug to reduce half of its initial value

A

Half life

1007
Q

Rate at which drug is removed from the body

A

Clearance

1008
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1009
Q

Constant clearance, not constant half life

A

Zero order kinetics

1010
Q

Not constant clearance, constant half life

A

First order kinetics

1011
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1012
Q

Dosage of drug needed to produce an effect

A

Potency

1013
Q

Effect of drug

A

Efficacy

1014
Q

How well drug can be used in the real world

A

Effectiveness

1015
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1016
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1017
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1018
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1019
Q

Formula for therapeutic index

A

TI= LD50/ED50

1020
Q

Median effective dose

A

ED50

1021
Q

Median lethal dose

A

LD50

1022
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1023
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1024
Q

Receptor for pilocarpine

A

Muscarinic

1025
Q

Drug properties

A

Affinity

Intrinsic activity

1026
Q

Ability of drug to bind to target sites

A

Affinity

1027
Q

Ability of drug to produce an effect

A

Intrinsic activity

1028
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1029
Q

Types of antagonist

A

Competitive

Non-competitive

1030
Q

Competes with receptor sites of agonist

A

Competitive

1031
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1032
Q

Results in dec potency

A

Complete

1033
Q

Results in dec efficacy

A

Non competitive

1034
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1035
Q

Antagonist of benzodiazepines

A

Flumazenil

1036
Q

Acts as agonist and antagonist

A

Partial agonist

1037
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1038
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1039
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1040
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1041
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1042
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1043
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1044
Q

LA metabolized in the liver

A

Amide

1045
Q

LA metabolized in plasma

A

Esters

1046
Q

Time required for drug to reduce half of its initial value

A

Half life

1047
Q

Rate at which drug is removed from the body

A

Clearance

1048
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1049
Q

Constant clearance, not constant half life

A

Zero order kinetics

1050
Q

Not constant clearance, constant half life

A

First order kinetics

1051
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1052
Q

Dosage of drug needed to produce an effect

A

Potency

1053
Q

Effect of drug

A

Efficacy

1054
Q

How well drug can be used in the real world

A

Effectiveness

1055
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1056
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1057
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1058
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1059
Q

Formula for therapeutic index

A

TI= LD50/ED50

1060
Q

Median effective dose

A

ED50

1061
Q

Median lethal dose

A

LD50

1062
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1063
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1064
Q

Receptor for pilocarpine

A

Muscarinic

1065
Q

Drug properties

A

Affinity

Intrinsic activity

1066
Q

Ability of drug to bind to target sites

A

Affinity

1067
Q

Ability of drug to produce an effect

A

Intrinsic activity

1068
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1069
Q

Types of antagonist

A

Competitive

Non-competitive

1070
Q

Competes with receptor sites of agonist

A

Competitive

1071
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1072
Q

Results in dec potency

A

Complete

1073
Q

Results in dec efficacy

A

Non competitive

1074
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1075
Q

Antagonist of benzodiazepines

A

Flumazenil

1076
Q

Acts as agonist and antagonist

A

Partial agonist

1077
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1078
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1079
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1080
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1081
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1082
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1083
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1084
Q

LA metabolized in the liver

A

Amide

1085
Q

LA metabolized in plasma

A

Esters

1086
Q

Time required for drug to reduce half of its initial value

A

Half life

1087
Q

Rate at which drug is removed from the body

A

Clearance

1088
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1089
Q

Constant clearance, not constant half life

A

Zero order kinetics

1090
Q

Not constant clearance, constant half life

A

First order kinetics

1091
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1092
Q

Dosage of drug needed to produce an effect

A

Potency

1093
Q

Effect of drug

A

Efficacy

1094
Q

How well drug can be used in the real world

A

Effectiveness

1095
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1096
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1097
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1098
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1099
Q

Formula for therapeutic index

A

TI= LD50/ED50

1100
Q

Median effective dose

A

ED50

1101
Q

Median lethal dose

A

LD50

1102
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1103
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1104
Q

Receptor for pilocarpine

A

Muscarinic

1105
Q

Drug properties

A

Affinity

Intrinsic activity

1106
Q

Ability of drug to bind to target sites

A

Affinity

1107
Q

Ability of drug to produce an effect

A

Intrinsic activity

1108
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1109
Q

Types of antagonist

A

Competitive

Non-competitive

1110
Q

Competes with receptor sites of agonist

A

Competitive

1111
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1112
Q

Results in dec potency

A

Complete

1113
Q

Results in dec efficacy

A

Non competitive

1114
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1115
Q

Antagonist of benzodiazepines

A

Flumazenil

1116
Q

Acts as agonist and antagonist

A

Partial agonist

1117
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1118
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1119
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1120
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1121
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1122
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1123
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1124
Q

LA metabolized in the liver

A

Amide

1125
Q

LA metabolized in plasma

A

Esters

1126
Q

Time required for drug to reduce half of its initial value

A

Half life

1127
Q

Rate at which drug is removed from the body

A

Clearance

1128
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1129
Q

Constant clearance, not constant half life

A

Zero order kinetics

1130
Q

Not constant clearance, constant half life

A

First order kinetics

1131
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1132
Q

Dosage of drug needed to produce an effect

A

Potency

1133
Q

Effect of drug

A

Efficacy

1134
Q

How well drug can be used in the real world

A

Effectiveness

1135
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1136
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1137
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1138
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1139
Q

Formula for therapeutic index

A

TI= LD50/ED50

1140
Q

Median effective dose

A

ED50

1141
Q

Median lethal dose

A

LD50

1142
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1143
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1144
Q

Receptor for pilocarpine

A

Muscarinic

1145
Q

Drug properties

A

Affinity

Intrinsic activity

1146
Q

Ability of drug to bind to target sites

A

Affinity

1147
Q

Ability of drug to produce an effect

A

Intrinsic activity

1148
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1149
Q

Types of antagonist

A

Competitive

Non-competitive

1150
Q

Competes with receptor sites of agonist

A

Competitive

1151
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1152
Q

Results in dec potency

A

Complete

1153
Q

Results in dec efficacy

A

Non competitive

1154
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1155
Q

Antagonist of benzodiazepines

A

Flumazenil

1156
Q

Acts as agonist and antagonist

A

Partial agonist

1157
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1158
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1159
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1160
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1161
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1162
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1163
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1164
Q

LA metabolized in the liver

A

Amide

1165
Q

LA metabolized in plasma

A

Esters

1166
Q

Time required for drug to reduce half of its initial value

A

Half life

1167
Q

Rate at which drug is removed from the body

A

Clearance

1168
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1169
Q

Constant clearance, not constant half life

A

Zero order kinetics

1170
Q

Not constant clearance, constant half life

A

First order kinetics

1171
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1172
Q

Dosage of drug needed to produce an effect

A

Potency

1173
Q

Effect of drug

A

Efficacy

1174
Q

How well drug can be used in the real world

A

Effectiveness

1175
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1176
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1177
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1178
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1179
Q

Formula for therapeutic index

A

TI= LD50/ED50

1180
Q

Median effective dose

A

ED50

1181
Q

Median lethal dose

A

LD50

1182
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1183
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1184
Q

Receptor for pilocarpine

A

Muscarinic

1185
Q

Drug properties

A

Affinity

Intrinsic activity

1186
Q

Ability of drug to bind to target sites

A

Affinity

1187
Q

Ability of drug to produce an effect

A

Intrinsic activity

1188
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1189
Q

Types of antagonist

A

Competitive

Non-competitive

1190
Q

Competes with receptor sites of agonist

A

Competitive

1191
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1192
Q

Results in dec potency

A

Complete

1193
Q

Results in dec efficacy

A

Non competitive

1194
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1195
Q

Antagonist of benzodiazepines

A

Flumazenil

1196
Q

Acts as agonist and antagonist

A

Partial agonist

1197
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1198
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1199
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1200
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1201
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1202
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1203
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1204
Q

LA metabolized in the liver

A

Amide

1205
Q

LA metabolized in plasma

A

Esters

1206
Q

Time required for drug to reduce half of its initial value

A

Half life

1207
Q

Rate at which drug is removed from the body

A

Clearance

1208
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1209
Q

Constant clearance, not constant half life

A

Zero order kinetics

1210
Q

Not constant clearance, constant half life

A

First order kinetics

1211
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1212
Q

Dosage of drug needed to produce an effect

A

Potency

1213
Q

Effect of drug

A

Efficacy

1214
Q

How well drug can be used in the real world

A

Effectiveness

1215
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1216
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1217
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1218
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1219
Q

Formula for therapeutic index

A

TI= LD50/ED50

1220
Q

Median effective dose

A

ED50

1221
Q

Median lethal dose

A

LD50

1222
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1223
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1224
Q

Receptor for pilocarpine

A

Muscarinic

1225
Q

Drug properties

A

Affinity

Intrinsic activity

1226
Q

Ability of drug to bind to target sites

A

Affinity

1227
Q

Ability of drug to produce an effect

A

Intrinsic activity

1228
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1229
Q

Types of antagonist

A

Competitive

Non-competitive

1230
Q

Competes with receptor sites of agonist

A

Competitive

1231
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1232
Q

Results in dec potency

A

Complete

1233
Q

Results in dec efficacy

A

Non competitive

1234
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1235
Q

Antagonist of benzodiazepines

A

Flumazenil

1236
Q

Acts as agonist and antagonist

A

Partial agonist

1237
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1238
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1239
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1240
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1241
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1242
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1243
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1244
Q

LA metabolized in the liver

A

Amide

1245
Q

LA metabolized in plasma

A

Esters

1246
Q

Time required for drug to reduce half of its initial value

A

Half life

1247
Q

Rate at which drug is removed from the body

A

Clearance

1248
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1249
Q

Constant clearance, not constant half life

A

Zero order kinetics

1250
Q

Not constant clearance, constant half life

A

First order kinetics

1251
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1252
Q

Dosage of drug needed to produce an effect

A

Potency

1253
Q

Effect of drug

A

Efficacy

1254
Q

How well drug can be used in the real world

A

Effectiveness

1255
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1256
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1257
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1258
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1259
Q

Formula for therapeutic index

A

TI= LD50/ED50

1260
Q

Median effective dose

A

ED50

1261
Q

Median lethal dose

A

LD50

1262
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1263
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1264
Q

Receptor for pilocarpine

A

Muscarinic

1265
Q

Drug properties

A

Affinity

Intrinsic activity

1266
Q

Ability of drug to bind to target sites

A

Affinity

1267
Q

Ability of drug to produce an effect

A

Intrinsic activity

1268
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1269
Q

Types of antagonist

A

Competitive

Non-competitive

1270
Q

Competes with receptor sites of agonist

A

Competitive

1271
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1272
Q

Results in dec potency

A

Complete

1273
Q

Results in dec efficacy

A

Non competitive

1274
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1275
Q

Antagonist of benzodiazepines

A

Flumazenil

1276
Q

Acts as agonist and antagonist

A

Partial agonist

1277
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1278
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1279
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1280
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1281
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1282
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1283
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1284
Q

LA metabolized in the liver

A

Amide

1285
Q

LA metabolized in plasma

A

Esters

1286
Q

Time required for drug to reduce half of its initial value

A

Half life

1287
Q

Rate at which drug is removed from the body

A

Clearance

1288
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1289
Q

Constant clearance, not constant half life

A

Zero order kinetics

1290
Q

Not constant clearance, constant half life

A

First order kinetics

1291
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1292
Q

Dosage of drug needed to produce an effect

A

Potency

1293
Q

Effect of drug

A

Efficacy

1294
Q

How well drug can be used in the real world

A

Effectiveness

1295
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1296
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1297
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1298
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1299
Q

Formula for therapeutic index

A

TI= LD50/ED50

1300
Q

Median effective dose

A

ED50

1301
Q

Median lethal dose

A

LD50

1302
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1303
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1304
Q

Receptor for pilocarpine

A

Muscarinic

1305
Q

Drug properties

A

Affinity

Intrinsic activity

1306
Q

Ability of drug to bind to target sites

A

Affinity

1307
Q

Ability of drug to produce an effect

A

Intrinsic activity

1308
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1309
Q

Types of antagonist

A

Competitive

Non-competitive

1310
Q

Competes with receptor sites of agonist

A

Competitive

1311
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1312
Q

Results in dec potency

A

Complete

1313
Q

Results in dec efficacy

A

Non competitive

1314
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1315
Q

Antagonist of benzodiazepines

A

Flumazenil

1316
Q

Acts as agonist and antagonist

A

Partial agonist

1317
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1318
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1319
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1320
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1321
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1322
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1323
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1324
Q

LA metabolized in the liver

A

Amide

1325
Q

LA metabolized in plasma

A

Esters

1326
Q

Time required for drug to reduce half of its initial value

A

Half life

1327
Q

Rate at which drug is removed from the body

A

Clearance

1328
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1329
Q

Constant clearance, not constant half life

A

Zero order kinetics

1330
Q

Not constant clearance, constant half life

A

First order kinetics

1331
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1332
Q

Dosage of drug needed to produce an effect

A

Potency

1333
Q

Effect of drug

A

Efficacy

1334
Q

How well drug can be used in the real world

A

Effectiveness

1335
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1336
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1337
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1338
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1339
Q

Formula for therapeutic index

A

TI= LD50/ED50

1340
Q

Median effective dose

A

ED50

1341
Q

Median lethal dose

A

LD50

1342
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1343
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1344
Q

Receptor for pilocarpine

A

Muscarinic

1345
Q

Drug properties

A

Affinity

Intrinsic activity

1346
Q

Ability of drug to bind to target sites

A

Affinity

1347
Q

Ability of drug to produce an effect

A

Intrinsic activity

1348
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1349
Q

Types of antagonist

A

Competitive

Non-competitive

1350
Q

Competes with receptor sites of agonist

A

Competitive

1351
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1352
Q

Results in dec potency

A

Complete

1353
Q

Results in dec efficacy

A

Non competitive

1354
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1355
Q

Antagonist of benzodiazepines

A

Flumazenil

1356
Q

Acts as agonist and antagonist

A

Partial agonist

1357
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1358
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1359
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1360
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1361
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1362
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1363
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1364
Q

LA metabolized in the liver

A

Amide

1365
Q

LA metabolized in plasma

A

Esters

1366
Q

Time required for drug to reduce half of its initial value

A

Half life

1367
Q

Rate at which drug is removed from the body

A

Clearance

1368
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1369
Q

Constant clearance, not constant half life

A

Zero order kinetics

1370
Q

Not constant clearance, constant half life

A

First order kinetics

1371
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1372
Q

Dosage of drug needed to produce an effect

A

Potency

1373
Q

Effect of drug

A

Efficacy

1374
Q

How well drug can be used in the real world

A

Effectiveness

1375
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1376
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1377
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1378
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1379
Q

Formula for therapeutic index

A

TI= LD50/ED50

1380
Q

Median effective dose

A

ED50

1381
Q

Median lethal dose

A

LD50

1382
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1383
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1384
Q

Receptor for pilocarpine

A

Muscarinic

1385
Q

Drug properties

A

Affinity

Intrinsic activity

1386
Q

Ability of drug to bind to target sites

A

Affinity

1387
Q

Ability of drug to produce an effect

A

Intrinsic activity

1388
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1389
Q

Types of antagonist

A

Competitive

Non-competitive

1390
Q

Competes with receptor sites of agonist

A

Competitive

1391
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1392
Q

Results in dec potency

A

Complete

1393
Q

Results in dec efficacy

A

Non competitive

1394
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1395
Q

Antagonist of benzodiazepines

A

Flumazenil

1396
Q

Acts as agonist and antagonist

A

Partial agonist

1397
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1398
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1399
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1400
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1401
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1402
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1403
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1404
Q

Metabolized in the liver

A

Amide

1405
Q

Merabolized in plasma

A

Esters

1406
Q

Time required for drug to reduce half of its initial value

A

Half life

1407
Q

Rate at which drug is removed from the body

A

Clearance

1408
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1409
Q

Constant clearance, not constant half life

A

Zero order kinetics

1410
Q

Not constant clearance, constant half life

A

First order kinetics

1411
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1412
Q

Dosage of drug needed to produce an effect

A

Potency

1413
Q

Effect of drug

A

Efficacy

1414
Q

How well drug can be used in the real world

A

Effectiveness

1415
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1416
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1417
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1418
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1419
Q

Formula for therapeutic index

A

TI= LD50/ED50

1420
Q

Median effective dose

A

ED50

1421
Q

Median lethal dose

A

LD50

1422
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1423
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1424
Q

Receptor for pilocarpine

A

Muscarinic

1425
Q

Drug properties

A

Affinity

Intrinsic activity

1426
Q

Ability of drug to bind to target sites

A

Affinity

1427
Q

Ability of drug to produce an effect

A

Intrinsic activity

1428
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1429
Q

Types of antagonist

A

Competitive

Non-competitive

1430
Q

Competes with receptor sites of agonist

A

Competitive

1431
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1432
Q

Results in dec potency

A

Complete

1433
Q

Results in dec efficacy

A

Non competitive

1434
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1435
Q

Antagonist of benzodiazepines

A

Flumazenil

1436
Q

Acts as agonist and antagonist

A

Partial agonist

1437
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1438
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1439
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1440
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1441
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1442
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1443
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1444
Q

Metabolized in the liver

A

Amide

1445
Q

Merabolized in plasma

A

Esters

1446
Q

Time required for drug to reduce half of its initial value

A

Half life

1447
Q

Rate at which drug is removed from the body

A

Clearance

1448
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1449
Q

Constant clearance, not constant half life

A

Zero order kinetics

1450
Q

Not constant clearance, constant half life

A

First order kinetics

1451
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1452
Q

Dosage of drug needed to produce an effect

A

Potency

1453
Q

Effect of drug

A

Efficacy

1454
Q

How well drug can be used in the real world

A

Effectiveness

1455
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1456
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1457
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1458
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1459
Q

Formula for therapeutic index

A

TI= LD50/ED50

1460
Q

Median effective dose

A

ED50

1461
Q

Median lethal dose

A

LD50

1462
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1463
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1464
Q

Receptor for pilocarpine

A

Muscarinic

1465
Q

Drug properties

A

Affinity

Intrinsic activity

1466
Q

Ability of drug to bind to target sites

A

Affinity

1467
Q

Ability of drug to produce an effect

A

Intrinsic activity

1468
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1469
Q

Types of antagonist

A

Competitive

Non-competitive

1470
Q

Competes with receptor sites of agonist

A

Competitive

1471
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1472
Q

Results in dec potency

A

Complete

1473
Q

Results in dec efficacy

A

Non competitive

1474
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1475
Q

Antagonist of benzodiazepines

A

Flumazenil

1476
Q

Acts as agonist and antagonist

A

Partial agonist

1477
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1478
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1479
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1480
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1481
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1482
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1483
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1484
Q

Metabolized in the liver

A

Amide

1485
Q

Merabolized in plasma

A

Esters

1486
Q

Time required for drug to reduce half of its initial value

A

Half life

1487
Q

Rate at which drug is removed from the body

A

Clearance

1488
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1489
Q

Constant clearance, not constant half life

A

Zero order kinetics

1490
Q

Not constant clearance, constant half life

A

First order kinetics

1491
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1492
Q

Dosage of drug needed to produce an effect

A

Potency

1493
Q

Effect of drug

A

Efficacy

1494
Q

How well drug can be used in the real world

A

Effectiveness

1495
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1496
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1497
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1498
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1499
Q

Formula for therapeutic index

A

TI= LD50/ED50

1500
Q

Median effective dose

A

ED50

1501
Q

Median lethal dose

A

LD50

1502
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1503
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1504
Q

Receptor for pilocarpine

A

Muscarinic

1505
Q

Drug properties

A

Affinity

Intrinsic activity

1506
Q

Ability of drug to bind to target sites

A

Affinity

1507
Q

Ability of drug to produce an effect

A

Intrinsic activity

1508
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1509
Q

Types of antagonist

A

Competitive

Non-competitive

1510
Q

Competes with receptor sites of agonist

A

Competitive

1511
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1512
Q

Results in dec potency

A

Complete

1513
Q

Results in dec efficacy

A

Non competitive

1514
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1515
Q

Antagonist of benzodiazepines

A

Flumazenil

1516
Q

Acts as agonist and antagonist

A

Partial agonist

1517
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1518
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1519
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1520
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1521
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1522
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1523
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1524
Q

Metabolized in the liver

A

Amide

1525
Q

Merabolized in plasma

A

Esters

1526
Q

Time required for drug to reduce half of its initial value

A

Half life

1527
Q

Rate at which drug is removed from the body

A

Clearance

1528
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1529
Q

Constant clearance, not constant half life

A

Zero order kinetics

1530
Q

Not constant clearance, constant half life

A

First order kinetics

1531
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1532
Q

Dosage of drug needed to produce an effect

A

Potency

1533
Q

Effect of drug

A

Efficacy

1534
Q

How well drug can be used in the real world

A

Effectiveness

1535
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1536
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1537
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1538
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1539
Q

Formula for therapeutic index

A

TI= LD50/ED50

1540
Q

Median effective dose

A

ED50

1541
Q

Median lethal dose

A

LD50

1542
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1543
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1544
Q

Receptor for pilocarpine

A

Muscarinic

1545
Q

Drug properties

A

Affinity

Intrinsic activity

1546
Q

Ability of drug to bind to target sites

A

Affinity

1547
Q

Ability of drug to produce an effect

A

Intrinsic activity

1548
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1549
Q

Types of antagonist

A

Competitive

Non-competitive

1550
Q

Competes with receptor sites of agonist

A

Competitive

1551
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1552
Q

Results in dec potency

A

Complete

1553
Q

Results in dec efficacy

A

Non competitive

1554
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1555
Q

Antagonist of benzodiazepines

A

Flumazenil

1556
Q

Acts as agonist and antagonist

A

Partial agonist

1557
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1558
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1559
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1560
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1561
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1562
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1563
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1564
Q

Metabolized in the liver

A

Amide

1565
Q

Merabolized in plasma

A

Esters

1566
Q

Time required for drug to reduce half of its initial value

A

Half life

1567
Q

Rate at which drug is removed from the body

A

Clearance

1568
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1569
Q

Constant clearance, not constant half life

A

Zero order kinetics

1570
Q

Not constant clearance, constant half life

A

First order kinetics

1571
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1572
Q

Dosage of drug needed to produce an effect

A

Potency

1573
Q

Effect of drug

A

Efficacy

1574
Q

How well drug can be used in the real world

A

Effectiveness

1575
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1576
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1577
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1578
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1579
Q

Formula for therapeutic index

A

TI= LD50/ED50

1580
Q

Median effective dose

A

ED50

1581
Q

Median lethal dose

A

LD50

1582
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1583
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1584
Q

Receptor for pilocarpine

A

Muscarinic

1585
Q

Drug properties

A

Affinity

Intrinsic activity

1586
Q

Ability of drug to bind to target sites

A

Affinity

1587
Q

Ability of drug to produce an effect

A

Intrinsic activity

1588
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1589
Q

Types of antagonist

A

Competitive

Non-competitive

1590
Q

Competes with receptor sites of agonist

A

Competitive

1591
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1592
Q

Results in dec potency

A

Complete

1593
Q

Results in dec efficacy

A

Non competitive

1594
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1595
Q

Antagonist of benzodiazepines

A

Flumazenil

1596
Q

Acts as agonist and antagonist

A

Partial agonist

1597
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1598
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1599
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1600
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1601
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1602
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1603
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1604
Q

Metabolized in the liver

A

Amide

1605
Q

Merabolized in plasma

A

Esters

1606
Q

Time required for drug to reduce half of its initial value

A

Half life

1607
Q

Rate at which drug is removed from the body

A

Clearance

1608
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1609
Q

Constant clearance, not constant half life

A

Zero order kinetics

1610
Q

Not constant clearance, constant half life

A

First order kinetics

1611
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1612
Q

Dosage of drug needed to produce an effect

A

Potency

1613
Q

Effect of drug

A

Efficacy

1614
Q

How well drug can be used in the real world

A

Effectiveness

1615
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1616
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1617
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1618
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1619
Q

Formula for therapeutic index

A

TI= LD50/ED50

1620
Q

Median effective dose

A

ED50

1621
Q

Median lethal dose

A

LD50

1622
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1623
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1624
Q

Receptor for pilocarpine

A

Muscarinic

1625
Q

Drug properties

A

Affinity

Intrinsic activity

1626
Q

Ability of drug to bind to target sites

A

Affinity

1627
Q

Ability of drug to produce an effect

A

Intrinsic activity

1628
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1629
Q

Types of antagonist

A

Competitive

Non-competitive

1630
Q

Competes with receptor sites of agonist

A

Competitive

1631
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1632
Q

Results in dec potency

A

Complete

1633
Q

Results in dec efficacy

A

Non competitive

1634
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1635
Q

Antagonist of benzodiazepines

A

Flumazenil

1636
Q

Acts as agonist and antagonist

A

Partial agonist

1637
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1638
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1639
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1640
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1641
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1642
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1643
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1644
Q

Metabolized in the liver

A

Amide

1645
Q

Merabolized in plasma

A

Esters

1646
Q

Time required for drug to reduce half of its initial value

A

Half life

1647
Q

Rate at which drug is removed from the body

A

Clearance

1648
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1649
Q

Constant clearance, not constant half life

A

Zero order kinetics

1650
Q

Not constant clearance, constant half life

A

First order kinetics

1651
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1652
Q

Dosage of drug needed to produce an effect

A

Potency

1653
Q

Effect of drug

A

Efficacy

1654
Q

How well drug can be used in the real world

A

Effectiveness

1655
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1656
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1657
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1658
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1659
Q

Formula for therapeutic index

A

TI= LD50/ED50

1660
Q

Median effective dose

A

ED50

1661
Q

Median lethal dose

A

LD50

1662
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1663
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1664
Q

Receptor for pilocarpine

A

Muscarinic

1665
Q

Drug properties

A

Affinity

Intrinsic activity

1666
Q

Ability of drug to bind to target sites

A

Affinity

1667
Q

Ability of drug to produce an effect

A

Intrinsic activity

1668
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1669
Q

Types of antagonist

A

Competitive

Non-competitive

1670
Q

Competes with receptor sites of agonist

A

Competitive

1671
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1672
Q

Results in dec potency

A

Complete

1673
Q

Results in dec efficacy

A

Non competitive

1674
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1675
Q

Antagonist of benzodiazepines

A

Flumazenil

1676
Q

Acts as agonist and antagonist

A

Partial agonist

1677
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1678
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1679
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1680
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1681
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1682
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1683
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1684
Q

Metabolized in the liver

A

Amide

1685
Q

Merabolized in plasma

A

Esters

1686
Q

Time required for drug to reduce half of its initial value

A

Half life

1687
Q

Rate at which drug is removed from the body

A

Clearance

1688
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1689
Q

Constant clearance, not constant half life

A

Zero order kinetics

1690
Q

Not constant clearance, constant half life

A

First order kinetics

1691
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1692
Q

Dosage of drug needed to produce an effect

A

Potency

1693
Q

Effect of drug

A

Efficacy

1694
Q

How well drug can be used in the real world

A

Effectiveness

1695
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1696
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1697
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1698
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1699
Q

Formula for therapeutic index

A

TI= LD50/ED50

1700
Q

Median effective dose

A

ED50

1701
Q

Median lethal dose

A

LD50

1702
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1703
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1704
Q

Receptor for pilocarpine

A

Muscarinic

1705
Q

Drug properties

A

Affinity

Intrinsic activity

1706
Q

Ability of drug to bind to target sites

A

Affinity

1707
Q

Ability of drug to produce an effect

A

Intrinsic activity

1708
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1709
Q

Types of antagonist

A

Competitive

Non-competitive

1710
Q

Competes with receptor sites of agonist

A

Competitive

1711
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1712
Q

Results in dec potency

A

Complete

1713
Q

Results in dec efficacy

A

Non competitive

1714
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1715
Q

Antagonist of benzodiazepines

A

Flumazenil

1716
Q

Acts as agonist and antagonist

A

Partial agonist

1717
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1718
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1719
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1720
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1721
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1722
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1723
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1724
Q

Metabolized in the liver

A

Amide

1725
Q

Merabolized in plasma

A

Esters

1726
Q

Time required for drug to reduce half of its initial value

A

Half life

1727
Q

Rate at which drug is removed from the body

A

Clearance

1728
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1729
Q

Constant clearance, not constant half life

A

Zero order kinetics

1730
Q

Not constant clearance, constant half life

A

First order kinetics

1731
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1732
Q

Dosage of drug needed to produce an effect

A

Potency

1733
Q

Effect of drug

A

Efficacy

1734
Q

How well drug can be used in the real world

A

Effectiveness

1735
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1736
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1737
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1738
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1739
Q

Formula for therapeutic index

A

TI= LD50/ED50

1740
Q

Median effective dose

A

ED50

1741
Q

Median lethal dose

A

LD50

1742
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1743
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1744
Q

Receptor for pilocarpine

A

Muscarinic

1745
Q

Drug properties

A

Affinity

Intrinsic activity

1746
Q

Ability of drug to bind to target sites

A

Affinity

1747
Q

Ability of drug to produce an effect

A

Intrinsic activity

1748
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1749
Q

Types of antagonist

A

Competitive

Non-competitive

1750
Q

Competes with receptor sites of agonist

A

Competitive

1751
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1752
Q

Results in dec potency

A

Complete

1753
Q

Results in dec efficacy

A

Non competitive

1754
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1755
Q

Antagonist of benzodiazepines

A

Flumazenil

1756
Q

Acts as agonist and antagonist

A

Partial agonist

1757
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1758
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1759
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1760
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1761
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1762
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1763
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1764
Q

Metabolized in the liver

A

Amide

1765
Q

Merabolized in plasma

A

Esters

1766
Q

Time required for drug to reduce half of its initial value

A

Half life

1767
Q

Rate at which drug is removed from the body

A

Clearance

1768
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1769
Q

Constant clearance, not constant half life

A

Zero order kinetics

1770
Q

Not constant clearance, constant half life

A

First order kinetics

1771
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1772
Q

Dosage of drug needed to produce an effect

A

Potency

1773
Q

Effect of drug

A

Efficacy

1774
Q

How well drug can be used in the real world

A

Effectiveness

1775
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1776
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1777
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1778
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1779
Q

Formula for therapeutic index

A

TI= LD50/ED50

1780
Q

Median effective dose

A

ED50

1781
Q

Median lethal dose

A

LD50

1782
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1783
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1784
Q

Receptor for pilocarpine

A

Muscarinic

1785
Q

Drug properties

A

Affinity

Intrinsic activity

1786
Q

Ability of drug to bind to target sites

A

Affinity

1787
Q

Ability of drug to produce an effect

A

Intrinsic activity

1788
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1789
Q

Types of antagonist

A

Competitive

Non-competitive

1790
Q

Competes with receptor sites of agonist

A

Competitive

1791
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1792
Q

Results in dec potency

A

Complete

1793
Q

Results in dec efficacy

A

Non competitive

1794
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1795
Q

Antagonist of benzodiazepines

A

Flumazenil

1796
Q

Acts as agonist and antagonist

A

Partial agonist

1797
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1798
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1799
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1800
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1801
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1802
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1803
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1804
Q

Metabolized in the liver

A

Amide

1805
Q

Merabolized in plasma

A

Esters

1806
Q

Time required for drug to reduce half of its initial value

A

Half life

1807
Q

Rate at which drug is removed from the body

A

Clearance

1808
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1809
Q

Constant clearance, not constant half life

A

Zero order kinetics

1810
Q

Not constant clearance, constant half life

A

First order kinetics

1811
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1812
Q

Dosage of drug needed to produce an effect

A

Potency

1813
Q

Effect of drug

A

Efficacy

1814
Q

How well drug can be used in the real world

A

Effectiveness

1815
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1816
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1817
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1818
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1819
Q

Formula for therapeutic index

A

TI= LD50/ED50

1820
Q

Median effective dose

A

ED50

1821
Q

Median lethal dose

A

LD50

1822
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1823
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1824
Q

Receptor for pilocarpine

A

Muscarinic

1825
Q

Drug properties

A

Affinity

Intrinsic activity

1826
Q

Ability of drug to bind to target sites

A

Affinity

1827
Q

Ability of drug to produce an effect

A

Intrinsic activity

1828
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1829
Q

Types of antagonist

A

Competitive

Non-competitive

1830
Q

Competes with receptor sites of agonist

A

Competitive

1831
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1832
Q

Results in dec potency

A

Complete

1833
Q

Results in dec efficacy

A

Non competitive

1834
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1835
Q

Antagonist of benzodiazepines

A

Flumazenil

1836
Q

Acts as agonist and antagonist

A

Partial agonist

1837
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1838
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1839
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1840
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1841
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1842
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

1843
Q

Properties of Diphenhydramine HCL

A

LA
H1 Blocker
Sedative
Slight cholinergic effect

1844
Q

Metabolized in the liver

A

Amide

1845
Q

Merabolized in plasma

A

Esters

1846
Q

Time required for drug to reduce half of its initial value

A

Half life

1847
Q

Rate at which drug is removed from the body

A

Clearance

1848
Q

Types of clearance

A

Zero order kinetics

First order kinetics

1849
Q

Constant clearance, not constant half life

A

Zero order kinetics

1850
Q

Not constant clearance, constant half life

A

First order kinetics

1851
Q

Drug which has more chances of cumulation

A

Zero order kinetics

1852
Q

Dosage of drug needed to produce an effect

A

Potency

1853
Q

Effect of drug

A

Efficacy

1854
Q

How well drug can be used in the real world

A

Effectiveness

1855
Q

Effect of drug are dose dependent

A

Dose-effect relationship

1856
Q

Dose-response responses

A

Graded dose effect curve

Quantal dose effect curve

1857
Q

Degree of response of a single biological unit

A

Graded dose effect curve

1858
Q

Relationship bet increasing drug dosage and percent of population that shows drug’s pharmacological effect and lethal effect

A

Quantal dose effect curve

1859
Q

Formula for therapeutic index

A

TI= LD50/ED50

1860
Q

Median effective dose

A

ED50

1861
Q

Median lethal dose

A

LD50

1862
Q

Targets of drug action

A

Receptors
Enzymes
Drug acting as physical or chemical agents

1863
Q

Receptors for narcotics

A

Mu
Kappa
Delta

1864
Q

Receptor for pilocarpine

A

Muscarinic

1865
Q

Drug properties

A

Affinity

Intrinsic activity

1866
Q

Ability of drug to bind to target sites

A

Affinity

1867
Q

Ability of drug to produce an effect

A

Intrinsic activity

1868
Q

Receptor acting drugs

A

Full agonist
Antagonist
Partial agonist

1869
Q

Types of antagonist

A

Competitive

Non-competitive

1870
Q

Competes with receptor sites of agonist

A

Competitive

1871
Q

Does not compete with agonist and has own receptors

A

Non-competitive

1872
Q

Results in dec potency

A

Complete

1873
Q

Results in dec efficacy

A

Non competitive

1874
Q

Antagonist of narcotics

A

Naloxone

Naltrexone

1875
Q

Antagonist of benzodiazepines

A

Flumazenil

1876
Q

Acts as agonist and antagonist

A

Partial agonist

1877
Q

Drugs specifically bind and interact with their receptor

A

Stucture action relationship

1878
Q

Theories of structure action relationship

A

Clark’s Occutoational Theory

Paton’s Rate Theory

1879
Q

Drug effect is proportional to the number of receptors occupied

A

Clark’s occupational theory

1880
Q

Drug effect is proportional to rate at which drug and receptor combine

A

Paton’s Rate Theory

1881
Q

Accdg to Payton

Associates quickly, dissociates immediately; faster rate of binding

A

Agonist

1882
Q

Accdg to Payton:

Associates but dissociates slower; slow rate of binding

A

Antagonist

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