Pharmacology

Question 1

What are the 2 groups/classifications of cytotoxic therapy?

Answer 1

Cell cycle -specific

Non cell cycle -specific

Question 2

Cell cycle -specific cytotoxic therapy is relatively tumour specific. The dosage is more important than the duration of exposure. True/False?

Answer 2

False

Duration of exposure is more important than dosage

Question 3

What are the 2 main cell cycle -specific cytotoxic agents?

Answer 3

Antimetabolites

Mitotic spindle inhibitors

Question 4

List some examples of antimetabolite cytotoxic agents

Answer 4

Methotrexate
6-Mercaptopurine
Hydroxyurea

Question 5

List some examples of mitotic spindle inhibitors

Answer 5

Vincristine

Taxotere

Question 6

Non cell cycle -specific cytotoxic therapy is not tumour specific. The dosage is more important than the duration of exposure. True/False?

Answer 6

True

Question 7

List some examples of non cell cycle -specific cytotoxic agents

Answer 7

Chlorambucil
Carboplatin
Cis-platinum

Question 8

List some immediate side effects of cytotoxic therapy

Answer 8

Bone marrow suppression
Gut mucosal damage
Hair loss

Question 9

What is the emergency treatment for neutropenic sepsis?

Answer 9

Piperacillin/Tazobactam

+ gentamicin if severe

Question 10

Which antibody-drug conjugate is used as targeted chemotherapy for non-Hodgkins lymphoma?

Answer 10

Brentuximab Vedotin