Pharmacology

Question 1

Bioavailability

Answer 1

bioavailability = AUC oral/AUC IV

Question 2

Exponential function

Answer 2

C = Co.e-kt

Co= conc at time 0
k= rate constant

Question 3

Pharmacodynamics

Answer 3

KD = [D][R]

[DR]

Question 4

Enzyme kinetics

Answer 4

V= Vmax [S]
Km + [S]

v= initial velocity
Vmax = max initial velocity
Km= conc at which initial velocity is half to max initial velocity
S= substrate

Question 5

Pharmacokinetics

Answer 5

Cl: clearance
Vd: volume of distribution
τ ; time constant
K; rate constant
D: dose

Vd=D
Co

τ= 1
Kel

τ = VD
Cl

τ 1/2 = τlog e 2

loading dose = Vd.Cp
Maintenance dose = Cp.Cl