Pharmacology

Question 1

Metyrosine

Answer 1

Indication: Hypertension

Competitive inhibition of tyrosine hydroxylase

Question 2

Reserpine

Answer 2

Indication: Hypertension

Inhibits VMAT uptake of monoamines

Question 3

Bretylium

Answer 3

Indication: ventricular arrhythmia

Inhibit action potential generation and calcium dependent synaptic vesicle fusion

Question 4

Cocaine

Answer 4

Indication: analgesia in surgery

Blocks monoamine reuptake

Question 5

Amphetamine or ephedrine

Answer 5

Ind: narcolepsy, ADHD

Reverse monoamine re-uptake transporters

Question 6

Naloxone, Naltrexone

Answer 6

Ind: opioid overdose or dependence

Non-peptide blockers of opioid receptors in CNS

Question 7

SSRIs

Answer 7

Ind: depression/anxiety

Selective inhibition of serotonin re-uptake transporter

Question 8

ACE inhibitors e.g. lisinopril

Answer 8

Ind: hypertension

Inhibits peptide cleavage of angiotensin I to angiotensin II

Question 9

Phenylephrine

Answer 9

Ind: hypotension during surgery

Direct agonist of adrenergic receptor

Question 10

MAO inhibitors

Answer 10

Ind: depression

Blockage of cytoplasmic metabolism of monoamines

Question 11

L-DOPA

Answer 11

Ind: parkinson’s disease

Precursor of dopamine, stimulates dopamine production

Question 12

Carbidopa

Answer 12

Ind: parkinson’s disease
Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons from producing too much dopamine and norepinephrine

Question 13

Tyramine

Answer 13

Ind: ingested in diet, not therapeutic

Competes with NE for transport into synaptic vesicle