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Heme/Onc > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Clinical use nitroureas

A

brain tumors

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2
Q

Mechanism:

5-FU

A

PYrimidine analog inhibits thymidylate synthase

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2
Q

Etoposide/teniposide MOA

A

inhibit topoisomerase II

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2
Q

Vemurafenib MOA

A

small molecule inhibitor of BRAF+ melanoma

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3
Q

Imatinib toxicity

A

edema

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4
Q

Trastuzumab toxicity

A

heart

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5
Q

Mechanism:

Cytarabine

A

Pyrimidine analog inhibits DNA polymerase

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6
Q

Cisplatin/carboplatin toxicity

A
  1. Nephro: prevent with amifostine
  2. Oto
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7
Q

Erlotinib toxicity

A

rash

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8
Q

Imatinib clinical use

A

CML, GIST

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8
Q

Rituximab MOA

A

Monoclonal antibody against CD20

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8
Q

Tamoxifen/raloxifene MOA

A

SERM - antagonist breast, agonist bone

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8
Q

Trastuzumab MOA

A

Monoclonal antibody against HER-2 (c-erbB2), a tyrosine kinase receptor

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9
Q

Paclitaxel MOA

A

prevent mitotic spindle breakdown

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10
Q

Mechanism:

Bleomycin

A

Free radical formation induces DNA strand breaks

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10
Q

Toxicity

Dactinomycin

A

Myelosuppression

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11
Q

Erlotinib Clinical Use

A

NSCLC

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12
Q

Paclitaxel toxicity

A
  1. myelosuppression
  2. alopecia
  3. hypersensitivity
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12
Q

Tamoxifen toxicity

A

endometrial cancer

hot flashes

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13
Q

Microtubule inhibitors act on what cell cycle phase

A

M

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14
Q

vinblastine toxicity

A
  1. myelosuppression
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15
Q

Clinical use busulfan

A

CML and bone marrow ablation

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16
Q

Cell cycle phase

Cladribine (2CDA)

A

S

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17
Q

Vincristine/vinblastine MOA

A

bind beta-tubulin to prevent mitotic spindle formation

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18
Does raloxifene increase endometrial CA risk
no
19
Toxicity Doxorubicin
DCM Myelosuppression Alopecia
19
Bevacizumab MOA
VEGF monoclonal antibody
20
Clinical use Bleomycin
Testicular cancer Hodgkin Lymphoma
22
Mechanism: MTX
Folic acid analog inhibits dihydrofolate reductase
24
Toxicity: Cytarabine
Pancytopenia
24
Irinotecan/topotecan MOA
inhibits topoisomerase I
25
Toxicity Busulfan
1. Myelosuppression 2. Pulmonary fibrosis 3. hyperpigmentation
26
Cisplatin/carboplatin MOA
cross link DNA
27
Bevacizumab toxicity
1. hemorrhage 2. blood clots 3. impaired wound healing
28
Imatinib MOA
tyrosine kinase inhibitor BCR-ABL and c-kit
29
Cisplatin/carboplatin clinical use
testicular, bladder, ovary, lung
30
Nitroureas toxicity
CNS
31
Vincristine toxicity
1. neurotoxic 2. paralytic ileus
32
Hydroxyurea MOA
inhibits ribonucleotide reductase increases HbF concentration
34
Toxicity: Azathiprine, 6MP, 6TG
Myelosuppression Allopurinol and febuxostat toxicity
36
Cell cycle phase MTX
S
37
Cell cycle phase: Azathioprine
S
38
What is given to prevent DCM 2/2 doxorubicin
Dexrazoxane
40
Mechanism: Dactinomycin
Intercalates DNA
40
Hydroxyurea toxicity
1. severe myelosuppression 2. GI upset
42
Mechanism: Cladribine (2CDA)
Purine analog
43
Give mesna with what drug to prevent what
cyclophosphamide hemorrhagic cystitis
44
Clinical use Dactinomycin
Childhood tumors: Wilm's, Ewing, etc
45
Paclitaxel clinical use
ovarian and breast CA
46
Location of DNA cross link in cyclophosphamide
Guanine N7
48
What drug class Paclitaxel vincristine vinblastine
microtubule inhibitors
51
MTX toxicity
1. myelo, leucovorin-reversible 2. hepato 3. mucositis 4. pulmonary fibrosis
52
Hydroxyurea cell cycle phase
S
53
Clinical use: Cladribine (2CDA)
Hairy cell leukemia
54
Cell cycle phase 5FU
S
55
Mechanism: Azathioprine 6MP 6TG
Purine analog decreases purine synthesis
56
Toxicity Cyclophosphamide ifosfamide
1. Myelosuppression 2. hemorrhagic cystitis
57
Rituximab Toxicity
Progressive multifocal leukoencephalopathy
58
Mechanism: Doxorubicin
Free radical formation
59
Alkylating agent MOA
Cross links DNA
60
Etoposide/teniposide toxicity cell cycle phase
S/G2
61
Topical used to treat basal cell CA
5FU
62
What drug class: Bleomycin Dactinomycin Doxorubcin
Antitumor antibiotics
63
Toxicity Cladribine (2CDA)
1. Myelo 2. Nephro 3. Neuro
64
What drug class Bisulfan cyclophosphamide ifosfamide carmustine lomustine semustine streptozocin
Alkylating agents
65
Antimetabolites act on what cell cycle phase
S
66
Erlotinib MOA
EGFR tyrosine kinase inhibitor
67
Toxicity Bleomycin
Pulmonary fibrosis skin hyperpigmentation mucositis
68
Cell cycle phase Cytarabine
S
69
5FU toxicity
myelo, not reversible with leucovorin (folinic acid)
70
irinotecan/topotecan toxicity
1. severe myelosuppression 2. diarrhea
71
Antitumor antibiotics affect what cell cycle stage
G2

Heme/Onc (1 decks)

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