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Heme/Onc > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Clinical use nitroureas

A

brain tumors

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2
Q

Mechanism:

5-FU

A

PYrimidine analog inhibits thymidylate synthase

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2
Q

Etoposide/teniposide MOA

A

inhibit topoisomerase II

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2
Q

Vemurafenib MOA

A

small molecule inhibitor of BRAF+ melanoma

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3
Q

Imatinib toxicity

A

edema

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4
Q

Trastuzumab toxicity

A

heart

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5
Q

Mechanism:

Cytarabine

A

Pyrimidine analog inhibits DNA polymerase

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6
Q

Cisplatin/carboplatin toxicity

A
  1. Nephro: prevent with amifostine
  2. Oto
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7
Q

Erlotinib toxicity

A

rash

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8
Q

Imatinib clinical use

A

CML, GIST

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8
Q

Rituximab MOA

A

Monoclonal antibody against CD20

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8
Q

Tamoxifen/raloxifene MOA

A

SERM - antagonist breast, agonist bone

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8
Q

Trastuzumab MOA

A

Monoclonal antibody against HER-2 (c-erbB2), a tyrosine kinase receptor

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9
Q

Paclitaxel MOA

A

prevent mitotic spindle breakdown

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10
Q

Mechanism:

Bleomycin

A

Free radical formation induces DNA strand breaks

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10
Q

Toxicity

Dactinomycin

A

Myelosuppression

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11
Q

Erlotinib Clinical Use

A

NSCLC

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12
Q

Paclitaxel toxicity

A
  1. myelosuppression
  2. alopecia
  3. hypersensitivity
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12
Q

Tamoxifen toxicity

A

endometrial cancer

hot flashes

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13
Q

Microtubule inhibitors act on what cell cycle phase

A

M

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14
Q

vinblastine toxicity

A
  1. myelosuppression
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15
Q

Clinical use busulfan

A

CML and bone marrow ablation

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16
Q

Cell cycle phase

Cladribine (2CDA)

A

S

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17
Q

Vincristine/vinblastine MOA

A

bind beta-tubulin to prevent mitotic spindle formation

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18
Q

Does raloxifene increase endometrial CA risk

A

no

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19
Q

Toxicity

Doxorubicin

A

DCM

Myelosuppression

Alopecia

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19
Q

Bevacizumab MOA

A

VEGF monoclonal antibody

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20
Q

Clinical use

Bleomycin

A

Testicular cancer

Hodgkin Lymphoma

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22
Q

Mechanism:

MTX

A

Folic acid analog inhibits dihydrofolate reductase

24
Q

Toxicity:

Cytarabine

A

Pancytopenia

24
Q

Irinotecan/topotecan MOA

A

inhibits topoisomerase I

25
Q

Toxicity

Busulfan

A
  1. Myelosuppression
  2. Pulmonary fibrosis
  3. hyperpigmentation
26
Q

Cisplatin/carboplatin MOA

A

cross link DNA

27
Q

Bevacizumab toxicity

A
  1. hemorrhage
  2. blood clots
  3. impaired wound healing
28
Q

Imatinib MOA

A

tyrosine kinase inhibitor BCR-ABL and c-kit

29
Q

Cisplatin/carboplatin clinical use

A

testicular, bladder, ovary, lung

30
Q

Nitroureas toxicity

A

CNS

31
Q

Vincristine toxicity

A
  1. neurotoxic
  2. paralytic ileus
32
Q

Hydroxyurea MOA

A

inhibits ribonucleotide reductase

increases HbF concentration

34
Q

Toxicity:

Azathiprine, 6MP, 6TG

A

Myelosuppression

Allopurinol and febuxostat toxicity

36
Q

Cell cycle phase

MTX

A

S

37
Q

Cell cycle phase:

Azathioprine

A

S

38
Q

What is given to prevent DCM 2/2 doxorubicin

A

Dexrazoxane

40
Q

Mechanism:

Dactinomycin

A

Intercalates DNA

40
Q

Hydroxyurea toxicity

A
  1. severe myelosuppression
  2. GI upset
42
Q

Mechanism:

Cladribine (2CDA)

A

Purine analog

43
Q

Give mesna with what drug to prevent what

A

cyclophosphamide

hemorrhagic cystitis

44
Q

Clinical use

Dactinomycin

A

Childhood tumors: Wilm’s, Ewing, etc

45
Q

Paclitaxel clinical use

A

ovarian and breast CA

46
Q

Location of DNA cross link in cyclophosphamide

A

Guanine N7

48
Q

What drug class

Paclitaxel

vincristine

vinblastine

A

microtubule inhibitors

51
Q

MTX toxicity

A
  1. myelo, leucovorin-reversible
  2. hepato
  3. mucositis
  4. pulmonary fibrosis
52
Q

Hydroxyurea cell cycle phase

A

S

53
Q

Clinical use:

Cladribine (2CDA)

A

Hairy cell leukemia

54
Q

Cell cycle phase

5FU

A

S

55
Q

Mechanism:

Azathioprine

6MP

6TG

A

Purine analog decreases purine synthesis

56
Q

Toxicity

Cyclophosphamide

ifosfamide

A
  1. Myelosuppression
  2. hemorrhagic cystitis
57
Q

Rituximab Toxicity

A

Progressive multifocal leukoencephalopathy

58
Q

Mechanism:

Doxorubicin

A

Free radical formation

59
Q

Alkylating agent MOA

A

Cross links DNA

60
Q

Etoposide/teniposide toxicity cell cycle phase

A

S/G2

61
Q

Topical used to treat basal cell CA

A

5FU

62
Q

What drug class:

Bleomycin

Dactinomycin

Doxorubcin

A

Antitumor antibiotics

63
Q

Toxicity

Cladribine (2CDA)

A
  1. Myelo
  2. Nephro
  3. Neuro
64
Q

What drug class

Bisulfan

cyclophosphamide

ifosfamide

carmustine

lomustine

semustine

streptozocin

A

Alkylating agents

65
Q

Antimetabolites act on what cell cycle phase

A

S

66
Q

Erlotinib MOA

A

EGFR tyrosine kinase inhibitor

67
Q

Toxicity

Bleomycin

A

Pulmonary fibrosis

skin hyperpigmentation

mucositis

68
Q

Cell cycle phase

Cytarabine

A

S

69
Q

5FU toxicity

A

myelo, not reversible with leucovorin (folinic acid)

70
Q

irinotecan/topotecan toxicity

A
  1. severe myelosuppression
  2. diarrhea
71
Q

Antitumor antibiotics affect what cell cycle stage

A

G2

Heme/Onc (1 decks)

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