Pharmacology Flashcards
H2 Blockers
take H2 blockers before you DINE (table for 2)
CimetiDINE, ranitiDINE, famotiDINE, nizatiDINE
Reversible block of H2 receptors> decreased H secretion by parietal cells
Peptic ulcer, gastritis, mild esophageal reflux
H2 blocker
Potent inhibitor of cyt P450 antiadrenergic effects (prolactin release, gynecomastia, impotence)
Cimetidine
What H2 blockers decrease renal excretion of creatinine?
Cimetidine
ranitidine
PPI
ZOLE
omeprazole, lansoprazole, esomeprazole, pantoprazole, dexlansoprazole
Irreversibly inhibit H/K ATPase in Parietal cells
Peptic ulcer, gastritis, esophageal reflux, ZE syndrome
PPI
PPI SE
C. Dif infection
pneumonia
hip fractures (decreased Mg w/ long term use)
Bismuth, sucralfate
bind to ulcer base
provide physical protection
increase ulcer healing, travelers diarrhea
bismuth sucralfate
misoprostol
PGE1 analog
Increases production and secretion of gastric mucous barrier
decrease acid production
SE: diarrhea, aborficant
Prevention of NSAID induced ulcers
Maintains ductus arteriosus
Induces labor
Misoprostol
Octreotide
long acting somatostatin analog
SE: nausea, cramps, steatorrhea
Acute variceal bleeds
acromegaly
VIPoma
carcinoid tumors
ocreotide
AluMINUM hydroxide
aluMINIMUM amt of feces (constipation Hypophosphatemia proximal muscle weakeness osteodystrophy seizures
Mg Hydroxide
Mg= Must go to the bathroom
diarrhea
hyporeflexia
hypotension
cardiac arrest
Ca carbonate
hypercalcemia
rebound increase in acid
decrease affectiveness of other drugs (tetracycline)
Osmotic laxatives
Mg hydroxide, Mg citrate, polyethylene glycol, lactulose
Provide osmotic load to draw water out
SE: diarrhea, dehydration (abused by bulemics)
Constipation
osmotic laxatives
Infliximab
Monoclonal Ab to TNFa
SE: infection, fever, hypotension
Chrons disease, ulcerative colitis, rheumotoid collitis
chrons disease
Sulfasalazine
sulfapyridine (antibacterial) and 5 aminosalicylic acid (antiinflammatory)
activated by colonic BACTERIA
Ulcerative olitis, chrons
sulfasalazine
Ondansetron
At a party and feel queasy? keep ON DANcing w/ ONDANSteron
5HT antagonist
controls vomiting post op and helps pts w/ chemo
se: HA and constipation
Metoclopramide
D2 receptor antag
Increases resting tone, contractility, LES tone, motility
ANTIEMETIC
SE: increase parkinsonian effects
