Pharmacology

Question 1

H2 Blockers

Answer 1

take H2 blockers before you DINE (table for 2)

CimetiDINE, ranitiDINE, famotiDINE, nizatiDINE

Reversible block of H2 receptors> decreased H secretion by parietal cells

Question 2

Peptic ulcer, gastritis, mild esophageal reflux

Answer 2

H2 blocker

Question 3

Potent inhibitor of cyt P450
antiadrenergic effects (prolactin release, gynecomastia, impotence)

Answer 3

Cimetidine

Question 4

What H2 blockers decrease renal excretion of creatinine?

Answer 4

Cimetidine

ranitidine

Question 5

PPI

Answer 5

ZOLE

omeprazole, lansoprazole, esomeprazole, pantoprazole, dexlansoprazole

Irreversibly inhibit H/K ATPase in Parietal cells

Question 6

Peptic ulcer, gastritis, esophageal reflux, ZE syndrome

Answer 6

PPI

Question 7

PPI SE

Answer 7

C. Dif infection
pneumonia

hip fractures (decreased Mg w/ long term use)

Question 8

Bismuth, sucralfate

Answer 8

bind to ulcer base

provide physical protection

Question 9

increase ulcer healing, travelers diarrhea

Answer 9

bismuth sucralfate

Question 10

misoprostol

Answer 10

PGE1 analog
Increases production and secretion of gastric mucous barrier
decrease acid production

SE: diarrhea, aborficant

Question 11

Prevention of NSAID induced ulcers
Maintains ductus arteriosus
Induces labor

Answer 11

Misoprostol

Question 12

Octreotide

Answer 12

long acting somatostatin analog

SE: nausea, cramps, steatorrhea

Question 13

Acute variceal bleeds
acromegaly
VIPoma
carcinoid tumors

Answer 13

ocreotide

Question 14

AluMINUM hydroxide

Answer 14

aluMINIMUM amt of feces (constipation
Hypophosphatemia
proximal muscle weakeness
osteodystrophy
seizures

Question 15

Mg Hydroxide

Answer 15

Mg= Must go to the bathroom

diarrhea
hyporeflexia
hypotension
cardiac arrest

Question 16

Ca carbonate

Answer 16

hypercalcemia
rebound increase in acid
decrease affectiveness of other drugs (tetracycline)

Question 17

Osmotic laxatives

Answer 17

Mg hydroxide, Mg citrate, polyethylene glycol, lactulose

Provide osmotic load to draw water out

SE: diarrhea, dehydration (abused by bulemics)

Question 18

Constipation

Answer 18

osmotic laxatives

Question 19

Infliximab

Answer 19

Monoclonal Ab to TNFa

SE: infection, fever, hypotension

Question 20

Chrons disease, ulcerative colitis, rheumotoid collitis

Answer 20

chrons disease

Question 21

Sulfasalazine

Answer 21

sulfapyridine (antibacterial) and 5 aminosalicylic acid (antiinflammatory)

activated by colonic BACTERIA

Question 22

Ulcerative olitis, chrons

Answer 22

sulfasalazine

Question 23

Ondansetron

Answer 23

At a party and feel queasy? keep ON DANcing w/ ONDANSteron

5HT antagonist

controls vomiting post op and helps pts w/ chemo

se: HA and constipation

Question 24

Metoclopramide

Answer 24

D2 receptor antag
Increases resting tone, contractility, LES tone, motility
ANTIEMETIC

SE: increase parkinsonian effects

Question 25

Diabetic and post surgery gastroparesis

Answer 25

Metoclopramide