Pharmacology Flashcards
1
Q
Pilocarpine
A
- Cholinergic
- Agonist
- Muscarinic
- AchE sensitive
treats xerostomia (dry mouth) in cemo and sjogren’s pt.
2
Q
Bethanechol
A
- Cholinergic
- Agonist
- Muscarinic
- Not hydrolysed by AchE (longer lasting)
- for postoperative or postpartum urinary retention
3
Q
Neostigmine
A
- Cholinergic
- Agonist
- low doses Inhibits AchE, high dose blocks Achr
- Treats myasthenia Gravis
4
Q
Pyridostigmine
A
- Cholinergic
- Agonist
- low doses Inhibits AchE, high dose blocks Achr
- Treats myasthenia Gravis, nerve gas
5
Q
Edrophonium
A
- Cholinergic
- Agonist
- Inhibits AchE
- Diagnose myasthenia gravis
6
Q
Donepezil
A
- Cholinergic
- Agonist
- Inhibits AchE
- used in alzheimer’s
7
Q
Organophosphate Nerve Gases
A
- Cholinergic
- Agonist
- Inhibits AchE
- causes death by asphyxiation
8
Q
Atropine
A
- Cholinergic
- Antagonist
- Muscarinic competitive antagonist
- increases firing of SA Node.
9
Q
Scopolamine
A
- Cholinergic
- Antagonist
- Muscarinic competitive antagonist
- for motion sickness; Mostly M1 receptor
10
Q
Oxybutynin
A
- Cholinergic
- antagonist
- Muscarinic competitive antagonist
- for overactive blader; M1, M2, M3 receptor
11
Q
Tolterodine
A
- Cholinergic
- antagonist
- Muscarinic competitive antagonist
- for overactive blader; M1, M2, M3 receptor
12
Q
Rocuronium
A
- Cholinergic
- Antagonist
- competitive block at nicotinic receptor at the neuromuscular junction
- for use with anesthetic in surgery. also lethal injection.
- antagonised by AchEI’s
13
Q
Atracurium
A
- Cholinergic
- Antagonist
- competitive block at nicotinic receptor at the neuromuscular junction
- for use with anesthetic in surgery. also lethal injection.
- antagonised by AchEI’s
14
Q
succinylcholine
A
Cholinergic
- antagonist
- depolarizes Ach nicotinic receptor at MEP but is not hydrolized, desensitizes neuron
- used as muscle relaxer in surgery.
15
Q
tubocurarine
A
-cholinergic
Antagonist
- Blocks nicotinic neuromuscular MEP
-used for tobacco withdrawal
16
Q
Epinepherine
A
Adrenergic
- agonist
- A1, B1, B2
- from adrenal medulla, used in asthma and cardiac failure
17
Q
Norepinephrine
A
Adrenergic
- agonist
- A1, B1, (A2)
- used in cases of neurogenic shock and vasodilatory shock, can be used as a vasopressor in critical hypotension
18
Q
Isoproterenol
A
Adrenergic
- agonist
- B1, B2
- uses are asthma and transient heart block
19
Q
Albuterol
A
Adrenergic
- agonist
- B2
- asthma
20
Q
Clonidine
A
Adrenergic
- agonist
- A2
- Hypertensive agent, crosses bb to hypothalamus A2 receptors to lower BP. also used to treat stress sleep and anxiety disorders.
21
Q
Phenylephrine
A
Adrinergic
- agonist
- A1
- treats nasal congestion and can be helpful with hypotensive shock
22
Q
Pseudophedrine
A
adrenergic
- agonist
- indirectly stimulates A and B receptors to release NorEpi
- used for congestion
23
Q
Dobutamine
A
Adrenergic
- Agonist
- B1
- used for Cardiac decompensation, decreased contractility from organic or surgical cause
24
Q
Dopamine
A
Adrenergic
- agonist
- D1 indirect- releases norepi and acts on B receptors in the heart
- used for hemodynamic imbalance, MI, shock, ect
25
Prazosin
Adrenergic
- Antagonist
- A1
- used for hypertension, BPH symptoms, severe heart failure
26
Doxazosin
Adrenergic
- Antagonist
- A1
- used for hypertension, BPH symptoms, severe heart failure
27
Terazosin
Adrenergic
- Antagonist
- A1
- BPH symptoms, some BP lowering
28
phentolamine
adrenergic
- antagonist
- A1, A2
- helps Diagnose pheochromocytoma or hypertensive crisis
29
phenoxybenzamine
adrenergic
- antagonist
- A1, A2
- helps sweating with a pheochromocytoma or essential hypertension
30
Metoprolol and Atenolol
Adrenergic
-antagonist
-B1
Atenolol (very lipid soluble) Angina and hypertension
Metoprolol- Acute MI, heart failure, hypertension, angina
31
propranolol
Adrenergic
- antagonist
- B1, B2
- heart and migraines
32
Labetalol
Adrenergic
- antagonist
- B1, B2, A1
- Hypertension, angina, preeclampsia
33
Carvadilol
Adrenergic
- antagonist
- B1, B2, A1
- Hypertension and NYHA class II or III heart failure
